A culturally-tailored dietary trial for cardiometabolic health in Puerto Rico
波多黎各心脏代谢健康的文化定制饮食试验
基本信息
- 批准号:10718150
- 负责人:
- 金额:$ 62.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-19 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdoptionAdultAmericanAtherosclerosisBiologicalBlood PressureCardiovascular DiseasesClinicalClinical TrialsConsumptionControl GroupsCooking UtensilsCounselingCultural BackgroundsDataDietDietary PracticesDrynessDyslipidemiasEquationExpenditureFabaceaeFoodFood AccessGoalsHealthHealth FoodHealthy EatingHigh Density LipoproteinsHouseholdHousehold ProductsHypertensionIndividualInterventionLaboratoriesMaintenanceMeasuresMediatingMediationMonitorNon-Insulin-Dependent Diabetes MellitusNutritionalNutritional StudyObesityOlives - dietaryOverweightParticipantPersonsPlasmaPopulationPopulation HeterogeneityPrediabetes syndromePsychosocial FactorPuerto RicoRecommendationReportingResourcesRiskRisk EstimateRisk FactorsRisk ReductionRoleSecureSelf EfficacySelf-control as a personality traitSocial supportSoybeansStrategic PlanningSumSupermarketTestingText MessagingTreatment EfficacyTriglyceridesUnited StatesUnited States National Institutes of HealthVegetable Oilsagedarmbeanblood lipidcardiometabolic riskcardiometabolismcardiovascular disorder riskclinically significantcohortdietarydietary guidelinesefficacy testingexperiencefood insecurityfood securityfruits and vegetablesglucose metabolismgood dietgroup interventionhealth disparityhigh riskhigh risk populationimprovedintervention effectmembermetabolomemultidisciplinaryportion controlprecision nutritionpredictive signaturepreventpreventive interventionprimary outcomeprogramspsychosocialrandomized trialrandomized, clinical trialsresponsesatisfactionsocialtexting supporttreatment armvoucher
项目摘要
Project Summary
The PREDIMED trial produced strong evidence showing that adhering to a Mediterranean dietary
pattern is associated with lower risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). Yet such a diet
may not be familiar or accessible to populations of different cultural backgrounds. Few clinical trials have
examined the mechanisms that contribute to cardiometabolic improvements, posited to be through changes in
the metabolome profile, psychosocial factors, or access to food. Our overall goal is to prevent CVD and T2D
among high-risk adults in the United States (US) territory of Puerto Rico (PR), where cardiometabolic burden
is excessive, by promoting a healthy, accessible, and culturally appropriate diet. In response, we led PROMED
(Puerto Rico-Optimized Mediterranean-like Diet #NCT03975556), a 4-mo, 2-arm, parallel pilot and feasibility
randomized trial that tested the efficacy of a culturally tailored intervention vs. standard healthy eating
program in improving cardiometabolic risk factors in 44 adults in PR. Participants highly rated PROMED’s
cultural acceptability, practicality, and satisfaction. The short-term benefits on blood pressure and HDL-C need
to be tested long-term. We therefore propose to test these mechanisms and the intervention’s efficacy by
expanding PROMED to a 2-year, 2-arm, parallel randomized clinical trial among 250 free-living adults aged
30-65y in PR with at least one dysregulated risk factor but free of CVD or T2D. The intervention group will
receive culturally tailored portion-control advice through monthly individual counseling reinforced with daily
text messages, and a monthly supply of legumes, vegetable oils, and locally produced fruit and vegetables.
Participants in the control arm will receive standard portion-control non-tailored nutritional counseling in
monthly individual sessions reinforced with daily text messages and monthly supermarket vouchers, but no
foods. Primary outcomes are a cardiometabolic improvement score (CIS) denoting improved cumulative risk
factors at a clinically significant value and 10-year atherosclerotic CVD (ASCVD) risk estimated from the
pooled cohort equation. We aim to determine the biological mechanisms mediating the efficacy of PROMED vs.
control by measuring plasma metabolite signatures that predict changes in CIS and 10-year ASCVD risk; assess
change and mediation of psychosocial factors (self-efficacy, self-control, intent) on CIS, and ASCVD; and
ascertain changes in food security, access, and expenditure by group, and effects on diet, CIS, and ASCVD. As
an exploratory aim, we will assess spillover effect of the intervention by inviting one household member of 70
participants at random for clinical and laboratory assessments. We expect PROMED will improve participants’
cardiometabolic health and elucidate posited mechanisms of action of a healthy diet. This new rigorous
evidence will enhance dietary guidelines and shift the paradigm from recommending generalized diets to
adapting guidance according to the biological, psychosocial, and social needs of diverse populations.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JOSIEMER MATTEI其他文献
JOSIEMER MATTEI的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JOSIEMER MATTEI', 18)}}的其他基金
PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends
前景:波多黎各社会心理、环境和慢性病趋势观察研究
- 批准号:
10393805 - 财政年份:2018
- 资助金额:
$ 62.35万 - 项目类别:
Project Title: PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends
项目名称:PROSPECT:波多黎各社会心理、环境和慢性疾病趋势观察研究
- 批准号:
10408131 - 财政年份:2018
- 资助金额:
$ 62.35万 - 项目类别:
Project Title: PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends
项目名称:PROSPECT:波多黎各社会心理、环境和慢性疾病趋势观察研究
- 批准号:
10218260 - 财政年份:2018
- 资助金额:
$ 62.35万 - 项目类别:
Diet quality and cardiometabolic disparities among Latino ethnic subgroups
拉丁裔族群之间的饮食质量和心脏代谢差异
- 批准号:
8616192 - 财政年份:2014
- 资助金额:
$ 62.35万 - 项目类别:
Diet quality and cardiometabolic disparities among Latino ethnic subgroups
拉丁裔族群之间的饮食质量和心脏代谢差异
- 批准号:
9108165 - 财政年份:2014
- 资助金额:
$ 62.35万 - 项目类别:
Diet quality and cardiometabolic disparities among Latino ethnic subgroups
拉丁裔族群之间的饮食质量和心脏代谢差异
- 批准号:
8913255 - 财政年份:2014
- 资助金额:
$ 62.35万 - 项目类别:
Diet quality and cardiometabolic disparities among Latino ethnic subgroups
拉丁裔族群之间的饮食质量和心脏代谢差异
- 批准号:
9318233 - 财政年份:2014
- 资助金额:
$ 62.35万 - 项目类别:
相似海外基金
WELL-CALF: optimising accuracy for commercial adoption
WELL-CALF:优化商业采用的准确性
- 批准号:
10093543 - 财政年份:2024
- 资助金额:
$ 62.35万 - 项目类别:
Collaborative R&D
Investigating the Adoption, Actual Usage, and Outcomes of Enterprise Collaboration Systems in Remote Work Settings.
调查远程工作环境中企业协作系统的采用、实际使用和结果。
- 批准号:
24K16436 - 财政年份:2024
- 资助金额:
$ 62.35万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 62.35万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 62.35万 - 项目类别:
EU-Funded
Assessing the Coordination of Electric Vehicle Adoption on Urban Energy Transition: A Geospatial Machine Learning Framework
评估电动汽车采用对城市能源转型的协调:地理空间机器学习框架
- 批准号:
24K20973 - 财政年份:2024
- 资助金额:
$ 62.35万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 62.35万 - 项目类别:
EU-Funded
Our focus for this project is accelerating the development and adoption of resource efficient solutions like fashion rental through technological advancement, addressing longer in use and reuse
我们该项目的重点是通过技术进步加快时装租赁等资源高效解决方案的开发和采用,解决更长的使用和重复使用问题
- 批准号:
10075502 - 财政年份:2023
- 资助金额:
$ 62.35万 - 项目类别:
Grant for R&D
Engage2innovate – Enhancing security solution design, adoption and impact through effective engagement and social innovation (E2i)
Engage2innovate — 通过有效参与和社会创新增强安全解决方案的设计、采用和影响 (E2i)
- 批准号:
10089082 - 财政年份:2023
- 资助金额:
$ 62.35万 - 项目类别:
EU-Funded
De-Adoption Beta-Blockers in patients with stable ischemic heart disease without REduced LV ejection fraction, ongoing Ischemia, or Arrhythmias: a randomized Trial with blinded Endpoints (ABbreviate)
在没有左心室射血分数降低、持续性缺血或心律失常的稳定型缺血性心脏病患者中停用β受体阻滞剂:一项盲法终点随机试验(ABbreviate)
- 批准号:
481560 - 财政年份:2023
- 资助金额:
$ 62.35万 - 项目类别:
Operating Grants
Collaborative Research: SCIPE: CyberInfrastructure Professionals InnoVating and brOadening the adoption of advanced Technologies (CI PIVOT)
合作研究:SCIPE:网络基础设施专业人员创新和扩大先进技术的采用 (CI PIVOT)
- 批准号:
2321091 - 财政年份:2023
- 资助金额:
$ 62.35万 - 项目类别:
Standard Grant














{{item.name}}会员




