Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

摘要 运动是一种强大的生理刺激，有助于疾病的预防和干预。这个 运动对新陈代谢、神经退行性变和 心血管疾病和某些癌症。虽然科学家们认识到了 关于运动，人们仍然对运动阻止运动的潜在机制了解不足 并改善不同器官系统的健康。美国国立卫生研究院共同基金制定了一项 前瞻性资助机制-六个捆绑在一起的RFA创建了一个研究联盟，分子 体力活动传感器联盟(MoTrPAC)-为以下项目创建资源和关键信息 运动和健康研究人员很好地进入了未来。MoTrPAC集体努力的两个产品将是 公共可用的数据资源，将加强和加速后续的机械研究 受体力活动影响的疾病和状况；临床和动物模型样本的生物储存库 用于研究运动生物学。基于之前的合作努力，我们团队相信我们是 最适合提出直接响应RFA的协议，同时执行 完成MoTrPAC联盟内每个站点所需的约450人的大量测试。 为了实现我们临床中心的所有目标，我们成立了一个联盟--北卡罗来纳临床中心 网站联盟(NCCSC)。NCCSC由经验丰富的研究团队组成，杜克大学学院 东卡罗来纳大学(ECU)和维克森林医学院(WFSM)。如中所述 在这项研究计划中，NCCSC权衡了许多训练方案、时间安排和组织类型的选择 抽样、四个义务研究小组的样本量和其他因素，同时保持在预算之内 约束条件。以下目标将最大化数据和样本库的价值；这将是 完成招生540人，完成450人。 ·目标1：确定分子换能器对单个急性有氧或有氧运动的反应 抵抗训练。 ·目标2：确定分子传感器对慢性运动训练计划的反应 要么是有氧训练，要么是阻力训练。 ·目标3：确定分子换能器在有氧或有氧运动后的脱训期的反应 或者是抵抗训练。

ABSTRACT Exercise is a powerful physiological stimulus contributing to disease prevention and intervention. The protective and preventive effects of exercise are well-documented for metabolic, neurodegenerative, and cardiovascular diseases, and certain cancers. While scientists acknowledge the extensive benefits of exercise, there is still insufficient understanding about the underlying mechanisms by which exercise prevents disease and improves health across diverse organ systems. The NIH Common Fund has developed a forward-looking funding mechanism — six tethered RFA's tied to creating a research consortium, the Molecular Transducers of Physical Activity Consortium (MoTrPAC) — to create resources and critical information for exercise and health investigators well into the future. Two products of the MoTrPAC collective efforts will be a publically available data resource that will enhance and accelerate subsequent mechanistic research on diseases and conditions affected by physical activity; and a biorepository of clinical and animal model samples to be used in studying exercise biology. Based on prior collaborative efforts, our group believes that we are ideally positioned to propose a protocol that will respond directly to the RFA, while at the same time execute the large volume of tests to complete the ~450 people required at each site within the MoTrPAC consortium. To accomplish all of our Clinical Center goals, we have developed a consortium — the North Carolina Clinical Site Consortium (NCCSC). The NCCSC consists of the experienced research teams Duke University School of Medicine; East Carolina University (ECU); and Wake Forest School of Medicine (WFSM). As described in the study plan, the NCCSC weighed a number of alternatives for training regimens, timing, and type of tissue sampling, sample sizes for the four obligated study groups, and other factors, while staying within budget constraints. The following Aims will maximize the value of the data and sample repositories; this will be accomplished with the enrollment of 540 individuals and finishing 450. · Aim 1: To determine the response of molecular transducers to a single acute bout of either aerobic or resistance training. · Aim 2: To determine the responses of molecular transducers to a chronic exercise training program of either aerobic or resistance training. · Aim 3: To determine the responses of molecular transducers to a detraining period following either aerobic or resistance training.