Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

身体活动与健康的分子传感器：NC 联盟临床站点

• 批准号: 10322153
• 负责人: Joseph A Houmard
• 金额: $ 237.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2023-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10322153
• 关键词: Acute; Address; Adipose tissue; Aerobic; Affect; Animal Model; Area; Automobile Driving; Behavior Therapy; Biology; Biopsy; Blood; Blood specimen; Body Composition; Budgets; Cardiovascular Diseases; Chronic; Clinical; Clinical Protocols; Collaborations; Data; Data Set; Disease; Enrollment; Exercise; Exercise Test; Funding; Funding Mechanisms; Future; Glucose tolerance test; Goals; Guidelines; Health; Heart failure; Hour; Human; Individual; Intervention; Intervention Studies; Life Style; Malignant Neoplasms; Measures; Mediating; Metabolic Diseases; Molecular; Muscle; Neurodegenerative Disorders; North Carolina; Participant; Peripheral; Persons; Physical activity; Physiological; Positioning Attribute; Preventive; Protocols documentation; Publishing; Quality Control; Recording of previous events; Regimen; Research; Research Design; Research Personnel; Resources; Sample Size; Sampling; Scientist; Signal Pathway; Site; Stimulus; Testing; Time; Tissue Sample; Training; Training Programs; Transducers; United States National Institutes of Health; Universities; Urine; Validation; Work; base; biobank; body system; clinical center; clinical research site; data resource; disorder prevention; exercise training; experience; forest; improved; medical schools; physical conditioning; prevent; protective effect; recruit; repository; response; sample collection; strength training; treadmill

ABSTRACT Exercise is a powerful physiological stimulus contributing to disease prevention and intervention. The protective and preventive effects of exercise are well-documented for metabolic, neurodegenerative, and cardiovascular diseases, and certain cancers. While scientists acknowledge the extensive benefits of exercise, there is still insufficient understanding about the underlying mechanisms by which exercise prevents disease and improves health across diverse organ systems. The NIH Common Fund has developed a forward-looking funding mechanism — six tethered RFA's tied to creating a research consortium, the Molecular Transducers of Physical Activity Consortium (MoTrPAC) — to create resources and critical information for exercise and health investigators well into the future. Two products of the MoTrPAC collective efforts will be a publically available data resource that will enhance and accelerate subsequent mechanistic research on diseases and conditions affected by physical activity; and a biorepository of clinical and animal model samples to be used in studying exercise biology. Based on prior collaborative efforts, our group believes that we are ideally positioned to propose a protocol that will respond directly to the RFA, while at the same time execute the large volume of tests to complete the ~450 people required at each site within the MoTrPAC consortium. To accomplish all of our Clinical Center goals, we have developed a consortium — the North Carolina Clinical Site Consortium (NCCSC). The NCCSC consists of the experienced research teams Duke University School of Medicine; East Carolina University (ECU); and Wake Forest School of Medicine (WFSM). As described in the study plan, the NCCSC weighed a number of alternatives for training regimens, timing, and type of tissue sampling, sample sizes for the four obligated study groups, and other factors, while staying within budget constraints. The following Aims will maximize the value of the data and sample repositories; this will be accomplished with the enrollment of 540 individuals and finishing 450. · Aim 1: To determine the response of molecular transducers to a single acute bout of either aerobic or resistance training. · Aim 2: To determine the responses of molecular transducers to a chronic exercise training program of either aerobic or resistance training. · Aim 3: To determine the responses of molecular transducers to a detraining period following either aerobic or resistance training.

抽象的 运动是一种强大的身体刺激，导致预防疾病和干预。这 锻炼的保护性和预防作用有据可查的代谢，神经退行性和 心血管疾病和某些癌症。科学家承认 锻炼，仍然对锻炼阻止的基本机制仍然没有足够的了解 疾病并改善潜水器官系统的健康。 NIH共同基金已经开发了 前瞻性基本机制 - 六个束缚的RFA与建立一个研究联盟相关，该联盟是分子 体育活动联盟（MOTRPAC）的传感器 - 创建资源和关键信息 锻炼和健康调查人员对未来充满信心。 Motrpac集体努力的两种产品将是 可公开可用的数据资源将增强和加速随后的机械研究 受体育锻炼影响的疾病和状况；以及临床和动物模型样品的生物座 用于研究运动生物学。根据先前的合作努力，我们的小组认为我们是 理想的定位是提出一个将直接响应RFA的协议，同时执行 大量测试完成了Motrpac财团内每个地点所需的约450人。 为了实现我们所有的临床中心目标，我们已经建立了一个财团 - 北卡罗来纳州的临床 现场财团（NCCSC）。 NCCSC由经验丰富的研究小组杜克大学学校组成 医学；东卡罗来纳大学（ECU）；和韦克森林医学院（WFSM）。如所述 研究计划，NCCSC重量用于训练方案，时机和类型的多种替代方法 抽样，四个义务研究组的样本量以及其他因素，同时保持预算范围内 约束。以下目的将最大化数据和样本存储库的价值；这将是 通过540个人的入学人数完成，并获得450人。 目标1：确定分子传感器对有氧或有氧或 抵抗训练。 目标2：确定分子传感器对慢性运动训练计划的反应 有氧或抵抗训练。 AIM 3：确定两种有氧运动后分子换能器对损坏周期的响应 或抵抗训练。