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Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

身体活动与健康的分子传感器：NC 联盟临床站点

基本信息

批准号：
10322153
负责人：
Joseph A Houmard
金额：
$ 237.5万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2023-09-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10322153
关键词：
Acute Address Adipose tissue Aerobic Affect Animal Model Area Automobile Driving Behavior Therapy Biology Biopsy Blood Blood specimen Body Composition Budgets Cardiovascular Diseases Chronic Clinical Clinical Protocols Collaborations Data Data Set Disease Enrollment Exercise Exercise Test Funding Funding Mechanisms Future Glucose tolerance test Goals Guidelines Health Heart failure Hour Human Individual Intervention Intervention Studies Life Style Malignant Neoplasms Measures Mediating Metabolic Diseases Molecular Muscle Neurodegenerative Disorders North Carolina Participant Peripheral Persons Physical activity Physiological Positioning Attribute Preventive Protocols documentation Publishing Quality Control Recording of previous events Regimen Research Research Design Research Personnel Resources Sample Size Sampling Scientist Signal Pathway Site Stimulus Testing Time Tissue Sample Training Training Programs Transducers United States National Institutes of Health Universities Urine Validation Work base biobank body system clinical center clinical research site data resource disorder prevention exercise training experience forest improved medical schools physical conditioning prevent protective effect recruit repository response sample collection strength training treadmill

项目摘要

ABSTRACT Exercise is a powerful physiological stimulus contributing to disease prevention and intervention. The protective and preventive effects of exercise are well-documented for metabolic, neurodegenerative, and cardiovascular diseases, and certain cancers. While scientists acknowledge the extensive benefits of exercise, there is still insufficient understanding about the underlying mechanisms by which exercise prevents disease and improves health across diverse organ systems. The NIH Common Fund has developed a forward-looking funding mechanism — six tethered RFA's tied to creating a research consortium, the Molecular Transducers of Physical Activity Consortium (MoTrPAC) — to create resources and critical information for exercise and health investigators well into the future. Two products of the MoTrPAC collective efforts will be a publically available data resource that will enhance and accelerate subsequent mechanistic research on diseases and conditions affected by physical activity; and a biorepository of clinical and animal model samples to be used in studying exercise biology. Based on prior collaborative efforts, our group believes that we are ideally positioned to propose a protocol that will respond directly to the RFA, while at the same time execute the large volume of tests to complete the ~450 people required at each site within the MoTrPAC consortium. To accomplish all of our Clinical Center goals, we have developed a consortium — the North Carolina Clinical Site Consortium (NCCSC). The NCCSC consists of the experienced research teams Duke University School of Medicine; East Carolina University (ECU); and Wake Forest School of Medicine (WFSM). As described in the study plan, the NCCSC weighed a number of alternatives for training regimens, timing, and type of tissue sampling, sample sizes for the four obligated study groups, and other factors, while staying within budget constraints. The following Aims will maximize the value of the data and sample repositories; this will be accomplished with the enrollment of 540 individuals and finishing 450. · Aim 1: To determine the response of molecular transducers to a single acute bout of either aerobic or resistance training. · Aim 2: To determine the responses of molecular transducers to a chronic exercise training program of either aerobic or resistance training. · Aim 3: To determine the responses of molecular transducers to a detraining period following either aerobic or resistance training.

摘要