Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

摘要 运动是一种强有力的生理刺激，有助于疾病的预防和干预。的 运动的保护和预防作用是有据可查的代谢，神经变性， 心血管疾病和某些癌症。虽然科学家们承认， 运动，仍然没有足够的了解的基本机制，运动防止 疾病，并改善不同器官系统的健康。美国国立卫生研究院共同基金开发了一个 前瞻性资助机制-六个系留RFA与创建一个研究联盟，分子 身体活动联盟（MoTrPAC）的传感器-为以下方面创建资源和关键信息 运动和健康调查员的未来。交通和公共行政部集体努力的两项成果将是： 可获得的数据资源，将增强和加速后续的机械研究， 受体力活动影响的疾病和病症;以及临床和动物模型样品的生物储存库 用于研究运动生物学。基于先前的合作努力，我们的团队认为， 非常适合提出直接响应RFA的协议，同时执行 在MoTrPAC联合体内的每个站点完成约450人所需的大量测试。 为了实现我们所有的临床中心目标，我们已经建立了一个联盟--北卡罗来纳州临床 研究中心联盟（NCCSC）。NCCSC由经验丰富的研究团队组成，杜克大学 东卡罗莱纳大学（ECU）和维克森林医学院（WFSM）。中所述 在研究计划中，NCCSC权衡了许多训练方案、时间和组织类型的替代方案 抽样，四个义务研究组的样本大小，以及其他因素，同时保持在预算范围内 约束以下目标将最大限度地提高数据和样本存储库的价值;这将是 完成了540人的登记和完成450。 ·目的1：确定分子转换器对有氧或有氧运动的单次急性发作的响应。 阻力训练 ·目的2：确定分子换能器对慢性运动训练计划的响应， 有氧或阻力训练。 ·目的3：确定分子转换器对有氧运动后的停训期的反应， 或阻力训练。

ABSTRACT Exercise is a powerful physiological stimulus contributing to disease prevention and intervention. The protective and preventive effects of exercise are well-documented for metabolic, neurodegenerative, and cardiovascular diseases, and certain cancers. While scientists acknowledge the extensive benefits of exercise, there is still insufficient understanding about the underlying mechanisms by which exercise prevents disease and improves health across diverse organ systems. The NIH Common Fund has developed a forward-looking funding mechanism — six tethered RFA's tied to creating a research consortium, the Molecular Transducers of Physical Activity Consortium (MoTrPAC) — to create resources and critical information for exercise and health investigators well into the future. Two products of the MoTrPAC collective efforts will be a publically available data resource that will enhance and accelerate subsequent mechanistic research on diseases and conditions affected by physical activity; and a biorepository of clinical and animal model samples to be used in studying exercise biology. Based on prior collaborative efforts, our group believes that we are ideally positioned to propose a protocol that will respond directly to the RFA, while at the same time execute the large volume of tests to complete the ~450 people required at each site within the MoTrPAC consortium. To accomplish all of our Clinical Center goals, we have developed a consortium — the North Carolina Clinical Site Consortium (NCCSC). The NCCSC consists of the experienced research teams Duke University School of Medicine; East Carolina University (ECU); and Wake Forest School of Medicine (WFSM). As described in the study plan, the NCCSC weighed a number of alternatives for training regimens, timing, and type of tissue sampling, sample sizes for the four obligated study groups, and other factors, while staying within budget constraints. The following Aims will maximize the value of the data and sample repositories; this will be accomplished with the enrollment of 540 individuals and finishing 450. · Aim 1: To determine the response of molecular transducers to a single acute bout of either aerobic or resistance training. · Aim 2: To determine the responses of molecular transducers to a chronic exercise training program of either aerobic or resistance training. · Aim 3: To determine the responses of molecular transducers to a detraining period following either aerobic or resistance training.