Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

身体活动与健康的分子传感器：NC 联盟临床站点

• 批准号: 10842000
• 负责人: Joseph A Houmard
• 金额: $ 253.54万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842000
• 关键词: 17 year old; 18 year old; Acute; Adipose tissue; Adult; Age; Age Years; Ancillary Study; Animals; Attention; Award; Bioinformatics; Biological Process; Blood; COVID-19; COVID-19 pandemic; California; Categories; Charge; Chemicals; Child; Childhood; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communication; Communities; Data; Development; Disease Outcome; Enrollment; Ensure; Exercise; Frequencies; Funding; Gender; Goals; Health; Health Benefit; Heterogeneity; Human; Individual; Institutional Review Boards; Intervention; Manuals; Manuscripts; Maps; Measurement; Minority Groups; Molecular; Multi-site clinical study; Muscle; Observational Study; Participant; Pathway interactions; Pediatric cohort; Phase; Phenotype; Physical activity; Physiological; Procedures; Protocols documentation; Public Health; Race; Randomized; Randomized, Controlled Trials; Recruitment Activity; Research; Research Personnel; Resistance; Resources; Rest; Site; Suspensions; Testing; Time; Tissues; Training; Training Programs; Transducers; United States National Institutes of Health; Universities; Visit; Woman; Youth; age group; clinical center; clinical research site; cohort; coronavirus disease; design; disorder risk; endurance exercise; ethnic minority; exercise intervention; exercise training; falls; follow-up; improved; innovation; insight; men; multiple omics; novel; operation; pandemic disease; phenotypic data; physical conditioning; pre-clinical; public database; quality assurance; racial minority; recruit; resistance exercise; response; sedentary; sex; working group

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers underlying the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators, not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex-balanced, with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, beginning in March 2020, MoTrPAC activities were suspended for over a year with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, the human clinical centers have successfully enrolled ~80% (adult) and 95% (pediatric) of the highly active cohort, ~93% of cross-sectional (pediatric), and ~60% (adult) and ~50% (pediatric) of the current target enrollment numbers in the randomized control trial portion of the study. This led to the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children, and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to the understanding of exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned, will provide a more complete public database of the health benefits of exercise, and will provide insight into how physical activity mitigates disease risk.

MoTrPAC项目摘要 物理活动联盟的分子传感器（MoTrPAC）旨在发现和 表征运动对人体影响的分子转换器的范围。MoTrPAC 于2016年推出，有六个成人临床中心和一个儿科中心合作， 生成广泛的操作手册，以指导涉及临床各个方面的研究方案 （第一阶段）。第二阶段于2019年秋季开始，所有人类临床中心均表现出色 实现初步招募目标和执行议定书的进展情况。提出的最初目标， NIH将招募270名儿童（10-17岁）和1980名久坐不动的成人（18岁或以上） 随机分为耐力训练组（170名青年，840名成人）、阻力训练组（840名成人）或非运动组。 对照组（50名青年，300名成人）。另一组高活动耐力（50名青年，150名成人）和 阻力（150名成年人）训练的个人作为比较，不参加MoTrPAC演习 培训项目。招募和登记方法是性别平衡的，参与者来自 年龄范围很广（10-17岁、18-39岁、40-59岁和>60岁年龄组），种族也不同。由于 2019冠状病毒病大流行，自2020年3月开始，MoTrPAC活动暂停超过一年， 到2022年仍有限制。尽管由于《公约》的实施而遇到了许多挑战， 在大流行期间，人类临床中心成功招募了约80%（成人）和95%（儿科）的 高活动性队列，约93%的横断面（儿科），约60%（成人）和约50%（儿科） 本研究随机对照试验部分的当前目标入组人数。这导致了NIH 共同基金发放当前的NOFO（RFA-RM-23-010），为交通和公共工程部提供资金， 完成临床研究的招募和随访，包括完成机械随机化 对久坐的成人和儿童进行的对照试验，以及对高度活跃的成人和 孩子这将丰富参与者队列，这对理解运动适应至关重要 以及年龄、性别和少数群体的异质性。总之，这一扩展将允许MoTrPAC 为了完成最初设想的预期目标，将提供一个更完整的公共数据库， 运动对健康的益处，并将深入了解身体活动如何减轻疾病风险。