Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

身体活动与健康的分子传感器：NC 联盟临床站点

• 批准号: 10842000
• 负责人: Joseph A Houmard
• 金额: $ 253.54万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10842000
• 关键词: 17 year old; 18 year old; Acute; Adipose tissue; Adult; Age; Age Years; Ancillary Study; Animals; Attention; Award; Bioinformatics; Biological Process; Blood; COVID-19; COVID-19 pandemic; California; Categories; Charge; Chemicals; Child; Childhood; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communication; Communities; Data; Development; Disease Outcome; Enrollment; Ensure; Exercise; Frequencies; Funding; Gender; Goals; Health; Health Benefit; Heterogeneity; Human; Individual; Institutional Review Boards; Intervention; Manuals; Manuscripts; Maps; Measurement; Minority Groups; Molecular; Multi-site clinical study; Muscle; Observational Study; Participant; Pathway interactions; Pediatric cohort; Phase; Phenotype; Physical activity; Physiological; Procedures; Protocols documentation; Public Health; Race; Randomized; Randomized, Controlled Trials; Recruitment Activity; Research; Research Personnel; Resistance; Resources; Rest; Site; Suspensions; Testing; Time; Tissues; Training; Training Programs; Transducers; United States National Institutes of Health; Universities; Visit; Woman; Youth; age group; clinical center; clinical research site; cohort; coronavirus disease; design; disorder risk; endurance exercise; ethnic minority; exercise intervention; exercise training; falls; follow-up; improved; innovation; insight; men; multiple omics; novel; operation; pandemic disease; phenotypic data; physical conditioning; pre-clinical; public database; quality assurance; racial minority; recruit; resistance exercise; response; sedentary; sex; working group

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers underlying the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators, not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex-balanced, with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, beginning in March 2020, MoTrPAC activities were suspended for over a year with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, the human clinical centers have successfully enrolled ~80% (adult) and 95% (pediatric) of the highly active cohort, ~93% of cross-sectional (pediatric), and ~60% (adult) and ~50% (pediatric) of the current target enrollment numbers in the randomized control trial portion of the study. This led to the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children, and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to the understanding of exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned, will provide a more complete public database of the health benefits of exercise, and will provide insight into how physical activity mitigates disease risk.

MoTrPAC项目摘要 体力活动分子传感器联合会(MoTrPAC)旨在发现和 描述运动对人体产生影响的分子传感器的范围。MoTrPAC 于2016年推出，拥有六个成人临床中心和一个儿科中心，已合作 编写广泛的操作手册，以指导涉及临床所有方面的研究方案 运营(第一阶段)。第二阶段于2019年秋季开始，所有人类临床中心均表现出色 在实现初步招聘目标和执行议定书方面取得进展。最初的目标是由 NIH计划招收270名儿童(10-17岁)和1980名久坐不动的成年人(18岁或以上)。 随机分为耐力训练(170名青年，840名成年人)、阻力训练(840名成年人)或不锻炼 对照组(50名青年，300名成人)。另一组高度活跃的耐力(50名青年，150名成年人)和 受过抵抗训练(150名成人)的个人作为参照者，不参加MoTrPAC演习 培训计划。招聘和注册方法是性别平衡的，参与者跨越 年龄范围广泛(10-17岁、18-39岁、40-59岁和&GT；60岁年龄组)和不同种族。由于 新冠肺炎大流行，从2020年3月开始，MoTrPAC的活动暂停了一年多， 持续到2022年的制约因素。尽管由于经济衰退而遇到许多挑战 在大流行期间，人类临床中心已成功招募了~80%(成人)和95%(儿科)的 高度活跃的队列，~93%的横断面(儿科)，~60%(成人)和~50%(儿科) 该研究的随机对照试验部分的当前目标登记人数。这导致了美国国立卫生研究院 共同基金将释放目前的NOFO(RFA-RM-23-010)，为MoTrPAC提供资金，以 完成临床研究的招募和跟踪，包括完成机械性随机分组 对久坐不动的成年人和儿童的对照试验，以及对高度活跃的成年人和 孩子们。这将丰富对理解运动适应至关重要的参与者队列 以及年龄、性别和少数群体的异质性。总而言之，此扩展将允许MoTrPAC 为完成最初设想的预期目标，将提供一个更完整的公共数据库 运动对健康的好处，并将提供对体育活动如何降低疾病风险的洞察。