Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

身体活动与健康的分子传感器：NC 联盟临床站点

基本信息

批准号：
10842000
负责人：
Joseph A Houmard
金额：
$ 253.54万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10842000
关键词：
17 year old 18 year old Acute Adipose tissue Adult Age Age Years Ancillary Study Animals Attention Award Bioinformatics Biological Process Blood COVID-19 COVID-19 pandemic California Categories Charge Chemicals Child Childhood Chronic Clinical Clinical Protocols Clinical Research Clinical Trials Data Monitoring Committees Collaborations Collection Communication Communities Data Development Disease Outcome Enrollment Ensure Exercise Frequencies Funding Gender Goals Health Health Benefit Heterogeneity Human Individual Institutional Review Boards Intervention Manuals Manuscripts Maps Measurement Minority Groups Molecular Multi-site clinical study Muscle Observational Study Participant Pathway interactions Pediatric cohort Phase Phenotype Physical activity Physiological Procedures Protocols documentation Public Health Race Randomized Randomized, Controlled Trials Recruitment Activity Research Research Personnel Resistance Resources Rest Site Suspensions Testing Time Tissues Training Training Programs Transducers United States National Institutes of Health Universities Visit Woman Youth age group clinical center clinical research site cohort coronavirus disease design disorder risk endurance exercise ethnic minority exercise intervention exercise training falls follow-up improved innovation insight men multiple omics novel operation pandemic disease phenotypic data physical conditioning pre-clinical public database quality assurance racial minority recruit resistance exercise response sedentary sex working group

项目摘要

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers underlying the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators, not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex-balanced, with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, beginning in March 2020, MoTrPAC activities were suspended for over a year with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, the human clinical centers have successfully enrolled ~80% (adult) and 95% (pediatric) of the highly active cohort, ~93% of cross-sectional (pediatric), and ~60% (adult) and ~50% (pediatric) of the current target enrollment numbers in the randomized control trial portion of the study. This led to the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children, and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to the understanding of exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned, will provide a more complete public database of the health benefits of exercise, and will provide insight into how physical activity mitigates disease risk.

MOTRPAC项目摘要体育活动联盟（MOTRPAC）的分子换能器旨在发现和表征了人类运动作用的基础分子传感器的范围。 motrpac 于2016年推出了六个成人临床中心和一个与儿科中心合作生成大量操作手册，以指导涉及临床各个方面的研究协议操作（第一阶段）。第二阶段始于2019年秋天，所有人类临床中心表现出色朝着最初的招聘目标和协议的实施迈进。最初提出的目标 NIH将招募270名儿童（10-17岁）和1980年久坐的成年人（18岁以上）随机进行耐力训练（170名青年，840名成人），抵抗训练（840名成人）或非运动对照（50名青年，300名成人）。另外一组高度积极的耐力（50名青年，150名成人）和阻力（150名成年人）训练有素的个体是比较者，不参加Motrpac练习培训计划。招聘和入学方法是性平衡的，参与者遍布范围很广的年龄（10-17、18-39、40-59和60岁年龄段）和不同的种族。由于 COVID-19-19大流行，从2020年3月开始，Motrpac活动被暂停了一年以上到2022年一直持续限制。尽管遇到了许多挑战大流行，人类临床中心已成功招募了约80％（成人）和95％（儿科）高度活跃的队列，约93％的横截面（小儿），约60％（成人）和〜50％（儿科）在研究的随机对照试验部分中的当前目标注册人数。这导致了NIH 释放当前NOFO（RFA-RM-23-010）的共同基金，为Motrpac提供资金临床研究的完整招募和随访，包括随机的完成机械久坐的成年人和儿童的对照试验，以及对高度活跃成年人的观察性研究孩子们。这将丰富参与者队列，这对于理解运动适应至关重要以及年龄，性别和少数群体的异质性。总共，此扩展将允许Motrpac 为了完成最初设想的预期目标，将提供更完整的公共数据库运动的健康益处，并将提供有关体育活动如何减轻疾病风险的见解。