Synthetic Biology and Biotechnology (SB2) Predoctoral Training Program

项目摘要/摘要 本申请寻求为合成生物学生物技术博士前培训项目提供资金 在波士顿大学。要求每年提供三个博士前培训时段，以支持学员 他们居住的第二年和第三年。合成生物学和生物技术(SB2)计划 旨在为合成生物学领域的顶尖研究人员做好准备。合成生物学使用工程学 构建用于研究和应用的复杂生物系统的方法，范围从工业 从化学到医学突破。这一快速发展的学科具有革命性的潜力 许多科学领域和行业，包括生物技术，我们的计划将是第一个 国家专门为学生准备合成生物学。一个本质上跨学科的领域，我们的 方案包括(A)在合成生物学原理和实践方面扎实的技术基础， (B)亲身接触生物技术研究和翻译新技术的商业化原则 合成生物学技术(C)和广泛的专业技能发展，包括团队合作 和沟通，这是在跨学科团队中取得成功所必需的。该课程包括一个 扎实的分子和细胞工程的教学基础，人工合成的理论和实践 生物学，数据分析，以及对商业化和工业研究目标的基本理解， 同时深入研究了广泛的潜在应用。体验式学习是 在整个课程中都强调。该计划的特点包括(1)在当地的暑期实习 生物技术公司，(2)合成生物学实验室引入最先进的技术和数据 分析方法论，(3)对侧重于批判性思维和 实验设计和验证，(4)为期5天的生物技术强化培训课程 创业，(5)SB2年度研讨会和海报日，受训者在会上展示他们的 研究。始终强调在可重复和严谨的研究中发展技能 传播科学，并了解如何应用合成生物学来寻找新的解决方案 学术界和生物技术领域存在的问题。许多机制被用来协助 实习生为多样化的职业道路做准备，有正式和非正式的互动机会 来自各行各业的科学家。一支由20名导师组成的杰出培训团队来自 波士顿大学的各个系和学院，拥有工程学、生物学、 化学、药理学、计算机工程和物理学。所有学生都有一所小学和 次要顾问，一个专注于基础工具，一个专注于应用程序，以确保他们的 研究显然是有动机的，而且影响深远。学生在定义他们的 通过制定正式的个人发展计划，开展跨学科研究项目。

Project Summary/Abstract This application seeks funding for a Biotechnology Predoctoral Training Program in Synthetic Biology at Boston University. Three predoctoral training slots per year are requested, to support trainees for their second and third years of residence. The Synthetic Biology and Biotechnology (SB2) Program aims to prepare top researchers for careers in synthetic biology. Synthetic biology uses engineering approaches to build complex biological systems for research and applications, ranging from industrial chemistry to medical breakthroughs. This fast-growing discipline has the potential to revolutionize many scientific fields and industries, including biotechnology, and our program will be the first in the nation to prepare students specifically in synthetic biology. An intrinsically interdisciplinary field, our program integrates (a) solid technical foundation in the principles and practices of synthetic biology, (b) hands-on exposure to biotech research and the principles of commercialization for translating new synthetic biology technologies, (c) and extensive professional skills development, including teamwork and communication, necessary to success in interdisciplinary teams. The curriculum includes a strong didactic foundation in molecular and cellular engineering, the theory and practice of synthetic biology, data analysis, and basic understanding of commercialization and industrial research goals, along with in-depth examination of a broad range of potential applications. Experiential learning is emphasized throughout the curriculum. Program features include (1) summer internship in a local biotech company, (2) Synthetic Biology Laboratory to introduce state-of-the-art techniques and data analysis methodologies, (3) rigorous dissection of literature focusing on critical thinking and experimental design and validation, (4) a 5-day intensive training course in Biotechnology Entrepreneurship, (5) an SB2 Annual Seminar and Poster Day at which trainees present their research. Emphasis is placed throughout in developing skills in reproducible and rigorous research, in communicating science, and in understanding how to apply synthetic biology to find new solutions to existing problems in academia and biotechnology. Numerous mechanisms are employed to assist trainees in preparing for diverse career paths with formal and informal opportunities to interact with scientists from a range of careers. A distinguished training faculty of 20 mentors is drawn from various departments and colleges at Boston University, with expertise in engineering, biology, chemistry, pharmacology, computer engineering, and physics. All students have a primary and secondary advisor, one focused on foundational tools and one on applications, to ensure their research is clearly motivated and far-reaching. Students play critical roles in defining their interdisciplinary research projects by developing a formal Individual Development Plan.