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Remote STATE training for Insomnia in Older Adults

针对老年人失眠的远程 STATE 培训

基本信息

批准号：
10393889
负责人：
Thomas VanVleet
金额：
$ 53.44万
依托单位：
POSIT SCIENCE CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10393889
关键词：
Academy Acetylcholine Activities of Daily Living Address Adopted Adult Age American Attention Behavior Therapy Brain California Chronic Insomnia Clinic Clinical Cognition Cognitive Cognitive deficits Collaborations Control Groups Data Dependence Devices Dimensions Disease remission Elderly Electroencephalography Exhibits Functional disorder Goals Head Health Imaging ligands Impaired cognition Inadequate Sleep Hygiene International Internet Intervention Judgment Maintenance Measures Medical Device Medicine Memory Mental Depression Moods Neurologic Neuronal Plasticity Neuropsychology Neurotransmitters Outcome Patients Persons Pharmaceutical Preparations Pharmacological Treatment Phase Pilot Projects Polysomnography Positron-Emission Tomography Prosencephalon Protocols documentation Public Health Quality of life Randomized Controlled Trials Research Risk San Francisco Sleep Sleep Deprivation Sleeplessness Societies Staging Supervision System Therapeutic Thinking Time Training Training Programs Translations Universities Vulnerable Populations active control aging population alertness base brain health clinically significant cognitive control cognitive function cognitive training comparative efficacy computerized cost design directed attention economic cost efficacy evaluation executive function fall risk follow up assessment functional independence healthy aging improved indexing member mortality neuroregulation novel poor sleep prevent primary outcome processing speed programs relating to nervous system rumination secondary outcome skill acquisition sleep behavior sleep onset sleep quality sleep regulation success sustained attention tool

项目摘要

PROJECT SUMMARY The goal of the current Phase II project is definitively evaluate the efficacy of a computerized cognitive training program (rSTATE) designed to improve sleep regulation and brain health and extend functional independence in older adults with insomnia. Nearly half of all adults over age sixty suffer disruptions in sleep that increase as a function of age. Nearly one third meet criteria for chronic insomnia, resulting in poor quality of life and increased risk of depression. Notably, cognitive decline in older adults with insomnia exceeds that observed in normal healthy aging. In addition to the obvious health and quality-of-life ramifications of late life insomnia, there are high economic costs. Thus, implementing scalable interventions to prevent functional dependence and cognitive impairment is of critical importance to overall public health. Here, we propose to evaluate a novel intervention that improve sleep, cognitive deficits and bolster functional abilities in patients with insomnia. Our preliminary data is among the first evidence to demonstrate that a neuroplasticity-based intervention has ‘real-world’ benefits and the potential to be a highly-scalable form of computerized cognitive training for providing protection against insomnia. At the completion of this project we will have outcomes data sufficient to support a compelling submission to the FDA for clearance as a medical device indicated for the treatment of insomnia.

项目摘要目前的第二阶段项目的目标是明确评估计算机化认知训练的有效性一项旨在改善睡眠调节和大脑健康并扩展功能独立性的计划（rSTATE）老年失眠症患者的情况。 60岁以上的成年人中，近一半的人睡眠中断，这种情况随着年龄的增长而增加。近一第三种符合慢性失眠的标准，导致生活质量下降并增加抑郁症的风险。值得注意的是，患有失眠症的老年人的认知能力下降超过了正常健康老年人的认知能力下降。在除了晚年失眠对健康和生活质量的明显影响外，成本因此，实施可扩展的干预措施来预防功能依赖和认知障碍是非常重要的。对整体公共卫生至关重要。在这里，我们建议评估一种新的干预措施，改善睡眠，认知缺陷和支持功能失眠症患者的能力。我们的初步数据是证明基于神经可塑性的干预具有“现实世界”的好处，并有可能成为一种高度可扩展的形式，电脑化认知训练，以防止失眠。在这个项目完成后，我们将有足够的结果数据来支持一个令人信服的提交， FDA批准其作为治疗失眠症的医疗器械。