Remote STATE training for Insomnia in Older Adults

项目总结 目前第二阶段项目的目标是明确评估计算机化认知训练的效果 旨在改善睡眠调节和大脑健康并延长功能独立性的程序(RSTATE) 在患有失眠的老年人中。 在所有60岁以上的成年人中，近一半的人会受到睡眠障碍的困扰，这种障碍会随着年龄的增长而增加。快一点了 第三，符合慢性失眠的标准，导致生活质量下降和抑郁风险增加。 值得注意的是，患有失眠的老年人的认知能力下降超过了正常健康衰老的情况。在……里面 除了老年失眠对健康和生活质量的明显影响外，还有很高的经济效益 成本。因此，实施可扩展的干预措施以防止功能依赖和认知障碍是 对整体公众健康至关重要。 在这里，我们建议评估一种新的干预措施，它可以改善睡眠、认知障碍和增强功能 失眠症患者的能力。我们的初步数据是第一批证明 以神经可塑性为基础的干预具有“现实世界”的好处，并有可能成为一种高度可扩展的 为防止失眠而进行的计算机化认知训练。 在这个项目完成时，我们将有足够的结果数据来支持令人信服的提交 FDA批准将其作为治疗失眠的医疗器械。

PROJECT SUMMARY The goal of the current Phase II project is definitively evaluate the efficacy of a computerized cognitive training program (rSTATE) designed to improve sleep regulation and brain health and extend functional independence in older adults with insomnia. Nearly half of all adults over age sixty suffer disruptions in sleep that increase as a function of age. Nearly one third meet criteria for chronic insomnia, resulting in poor quality of life and increased risk of depression. Notably, cognitive decline in older adults with insomnia exceeds that observed in normal healthy aging. In addition to the obvious health and quality-of-life ramifications of late life insomnia, there are high economic costs. Thus, implementing scalable interventions to prevent functional dependence and cognitive impairment is of critical importance to overall public health. Here, we propose to evaluate a novel intervention that improve sleep, cognitive deficits and bolster functional abilities in patients with insomnia. Our preliminary data is among the first evidence to demonstrate that a neuroplasticity-based intervention has ‘real-world’ benefits and the potential to be a highly-scalable form of computerized cognitive training for providing protection against insomnia. At the completion of this project we will have outcomes data sufficient to support a compelling submission to the FDA for clearance as a medical device indicated for the treatment of insomnia.