Remote STATE training for Insomnia in Older Adults

项目摘要 当前第二阶段项目的目标是明确评估计算机化认知训练的功效 一项旨在改善睡眠调节和大脑健康并扩展功能独立性的计划（rSTATE） 老年失眠症患者的情况。 60岁以上的成年人中，近一半的人睡眠中断，这种情况随着年龄的增长而增加。近一 三是符合慢性失眠标准，导致生活质量差，患抑郁症的风险增加。 值得注意的是，患有失眠症的老年人的认知能力下降超过了正常健康老年人的认知能力下降。在 除了晚年失眠对健康和生活质量的明显影响外， 成本因此，实施可扩展的干预措施来预防功能依赖和认知障碍是非常重要的。 对整体公共卫生至关重要。 在这里，我们建议评估一种新的干预措施，改善睡眠，认知缺陷和支持功能 失眠症患者的能力。我们的初步数据是证明 基于神经可塑性的干预具有“现实世界”的好处，并有可能成为一种高度可扩展的形式， 电脑化认知训练，以防止失眠。 在这个项目完成后，我们将有足够的结果数据来支持一个令人信服的提交， FDA批准其作为治疗失眠症的医疗器械。

PROJECT SUMMARY The goal of the current Phase II project is definitively evaluate the efficacy of a computerized cognitive training program (rSTATE) designed to improve sleep regulation and brain health and extend functional independence in older adults with insomnia. Nearly half of all adults over age sixty suffer disruptions in sleep that increase as a function of age. Nearly one third meet criteria for chronic insomnia, resulting in poor quality of life and increased risk of depression. Notably, cognitive decline in older adults with insomnia exceeds that observed in normal healthy aging. In addition to the obvious health and quality-of-life ramifications of late life insomnia, there are high economic costs. Thus, implementing scalable interventions to prevent functional dependence and cognitive impairment is of critical importance to overall public health. Here, we propose to evaluate a novel intervention that improve sleep, cognitive deficits and bolster functional abilities in patients with insomnia. Our preliminary data is among the first evidence to demonstrate that a neuroplasticity-based intervention has ‘real-world’ benefits and the potential to be a highly-scalable form of computerized cognitive training for providing protection against insomnia. At the completion of this project we will have outcomes data sufficient to support a compelling submission to the FDA for clearance as a medical device indicated for the treatment of insomnia.