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Remote Digital Health Intervention to Improve Balance and Reduce Fall Risk

远程数字健康干预可改善平衡并降低跌倒风险

基本信息

批准号：
10326128
负责人：
Thomas VanVleet
金额：
$ 25.49万
依托单位：
POSIT SCIENCE CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10326128
关键词：
Accidental Falls Activities of Daily Living Affect Age Apple watch Boston Brain California Cognition Cognitive Cognitive aging Collaborations Communities Computer software Data Development Devices Effectiveness Elderly Enrollment Ensure Equilibrium Exercise Fall prevention Feasibility Studies Feedback Focus Groups Fracture Funding Gait Goals Healthcare Human Impaired cognition Individual Injury Internet Intervention Intervention Studies Lead Learning Life Measures Medical Modeling Movement National Institute of Mental Health Outcome Participant Performance Persons Pharmacologic Substance Phase Population Premature Mortality Prevalence Provider Randomized Controlled Trials Research Design Research Personnel Resources Risk Role San Francisco Scientist Series Short-Term Memory Site Small Business Innovation Research Grant Tablet Computer Tablets Testing Time Training Training Programs Treatment Cost Treatment Protocols Universities Vulnerable Populations Wasabia Work active control age related arm base cognitive ability cognitive function cognitive training computerized cost design digital health disability economic cost executive function experience fall injury fall risk falls feasibility trial functional independence healthy aging human old age (65+)improved inclusion criteria meetings novel novel strategies open label phase 2 designs phase II trial prevent preventive intervention processing speed programs recruit remote intervention remote therapy standard measure success sustained attention training opportunity trial readiness usability

项目摘要

PROJECT SUMMARY The goal of the current Phase I proposal is to further develop (to pivotal trial readiness) and evaluate a computerized training program (rSTAND) to extend older adults’ functional independence and reduce fall risk. This intervention may benefit a large population of vulnerable older adults that are at an elevated risk for accidental falls with current lack of long-term viable treatment options. Approximately one third of community dwelling senior over age 65 are at risk of suffering at least one fall annually, resulting in fractures or other major injuries. Although numerous fall prevention interventions have been developed, the prevalence of falls is increasing and there are high economic costs for treatments of non- fatal fall injuries. Thus, prevention of falls in older adults is critically important to ensure sustained functional independence later in life, prevent disability due to fractures or worse (premature mortality) and maintain the viability of our limited health care resources. Here, we propose to complete the development and testing of novel computerized executive function/cognitive training program. The program targets core executive functions (working memory, inhibition), speed of processing and sustained attention, and is grounded on design principles that drive adaptive brain plasticity to improve cognitive function and bolster functional abilities in older adults with an elevated fall risk. At the completion of this project we will have outcomes data sufficient to support a large scale randomized controlled trial in Phase II designed to establish medical efficacy of this program for people with age-related elevated fall risk.

项目摘要当前I期提案的目标是进一步开发（关键试验准备就绪）和评估计算机化训练计划（rSTAND），以延长老年人的功能独立性，降低跌倒风险。这种干预可能会使大量易受伤害的老年人受益，这些老年人的风险较高，意外福尔斯跌倒，目前缺乏长期可行的治疗方案。大约三分之一的65岁以上的社区老年人面临至少一次跌倒的风险每年，导致骨折或其他重大伤害。尽管许多预防跌倒的干预措施随着技术的发展，福尔斯的患病率正在增加，治疗非跌倒的经济成本很高。致命的坠落伤因此，预防老年人的福尔斯跌倒对于确保持续的功能性康复至关重要。在以后的生活中独立，防止因骨折或更糟（过早死亡）而残疾，并保持我们有限的卫生保健资源的可行性。在这里，我们建议完成新型计算机执行功能/认知的开发和测试培训计划。该计划的目标核心执行功能（工作记忆，抑制），速度处理和持续的注意力，并基于设计原则，驱动自适应大脑可塑性，改善认知功能，增强跌倒风险较高的老年人的功能能力。在完成本项目后，我们将有足够的结果数据来支持大规模的随机对照研究。 II期试验，旨在确定该计划对年龄相关性高跌倒患者的医疗疗效风险