权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Amplified Attention Training (AAT) for the Treatment of Hemispatial Nelgect

放大注意力训练 (AAT) 用于治疗半侧空间忽视

基本信息

批准号：
8704441
负责人：
Thomas VanVleet
金额：
$ 88.79万
依托单位：
BRAIN PLASTICITY, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8704441
关键词：
Activities of Daily Living Aftercare Attention Auditory Boston Brain Injuries Capital Clinical Trials Design Code Cognition Cognitive deficits Computer software Data Discrimination Effectiveness Evaluation Executive Dysfunction Exercise Feedback Goals Hemispatial Neglect Hospitals ICD-9 Impairment Independent Living Individual Learning Lesion Managed Care Marketing Measures Medical Device Minor Modeling Modification Monitor Online Systems Outcome Participant Patient Education Patients Performance Phase Phase I Clinical Trials Physicians Population Psychologist Publishing Quality of life Randomized Controlled Clinical Trials Randomized Controlled Trials Rehabilitation therapy Research Personnel Rewards Site Specificity Stimulus Syndrome Therapeutic Intervention Time Training Training Programs United States Food and Drug Administration Universities Validation Washington base cognitive control cognitive enhancement cognitive function cognitive training commercialization computerized cost effective design effective therapy executive function experience functional outcomes improved interest medical schools multi-site trial neglect nervous system disorder novel outcome forecast patient population phase 1 study primary outcome programs prototype public health relevance standard of care standardize measure vigilance

项目摘要

DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized attention training program (Amplified Attention Training, AAT) for hemispatial neglect completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. As a group, patients with hemispatial neglect tend to have poorer long-term prognosis and are more likely to require managed care than other patient groups with lesions of comparable size. Our recent studies are among the first to demonstrate that AAT, targeting sustained attention & vigilance deficits, can produce lasting benefits. The overall goal of the current project is to measure 3 co-primary outcomes: attention, executive function and functional capacity. Evidence from our Phase I trial shows that AAT can improve attention and executive function deficits common to hemispatial neglect. At the completion of this project we will have outcomes data sufficient for submission to the FDA for clearance as a medical device indicated for cognitive enhancement in hemispatial neglect (ICD-9 Code 781.8).

描述（由申请人提供）：当前项目的目标是修改在I期完成的用于半侧空间忽视的计算机化注意力训练程序（放大注意力训练，AAT）的原型，并进行多中心、随机、对照试验以确定在该人群中的疗效。作为一个群体，半侧空间忽视患者往往有较差的长期预后，更有可能需要管理的护理比其他患者群体的病变相当的大小。我们最近的研究是第一批证明AAT，针对持续的注意力和警惕性缺陷，可以产生持久的好处。本项目的总体目标是测量3个共同主要结果：注意力、执行功能和功能能力。我们的I期试验的证据表明，AAT可以改善半侧空间忽视常见的注意力和执行功能缺陷。在本项目完成时，我们将获得足够的结局数据，以提交给FDA，作为适用于增强半侧空间忽视患者认知功能的医疗器械（ICD-9代码781.8）。