Community-based Brain Health Program to Address Dementia Risk (C-BBHP)

项目摘要 当前I期提案的目标是进一步开发（关键试验准备就绪）和评估 以社区为基础的脑健康计划，以解决痴呆症的风险（C-BBHP），其中包括多种干预措施 影响饮食、锻炼和认知健康的模式，旨在延长老年人的功能性 独立性和提高认知能力。这种干预可能会使大量人口受益， 易受伤害的老年人有患痴呆症的风险，目前缺乏长期可行的治疗方案。 痴呆症是美国最昂贵的医疗条件，目前，超过500万美国人 被诊断患有阿尔茨海默病（AD），这是最常见的痴呆症形式，并且随着年龄的增长，患病率正在扩大。 人口老龄化。除了痴呆症对健康和生活质量的明显影响外， 高经济成本。因此，实施可扩展的干预措施，以防止功能依赖， 痴呆症对整体公共卫生至关重要。 在这里，我们建议完成一个创新的多模式大脑健康计划的开发和测试， 通过基督教青年会的广泛网络在社区进行管理。该方案包括干预措施， 改善认知功能和增强痴呆风险患者的功能能力。完成时 在本项目中，我们将获得足够的结果数据，以支持在第二期进行的大规模随机对照试验。 II旨在确定该计划对有痴呆风险的老年人的医疗效果。

PROJECT SUMMARY The goal of the current Phase I proposal is to further develop (to pivotal trial readiness) and evaluate a community-based Brain Health Program to address dementia risk (C-BBHP) that includes multiple intervention modalities affecting diet, exercise and cognitive health designed to extend older adults’ functional independence and improve cognitive performance. This intervention may benefit a large population of vulnerable older adults that are at risk for dementia with current lack of long-term viable treatment options. Dementia is the most expensive medical condition in the U.S. Presently, more than 5 million Americans are diagnosed with Alzheimer’s disease (AD), the most common form of dementia, and prevalence is expanding as our population ages. In addition to the obvious health and quality-of-life ramifications of dementia, there are high economic costs. Thus, implementing scalable interventions to prevent functional dependence and dementia is of critical importance to overall public health. Here, we propose to complete the development and testing of an innovative multimodal brain health program, administered in communities via the broad network of the YMCA. The program is comprised of interventions to improve cognitive function and bolster functional abilities in patients with dementia risk. At the completion of this project we will have outcomes data sufficient to support a large scale randomized controlled trial in Phase II designed to establish medical efficacy of this program for older adults with dementia risk.