Community-based Brain Health Program to Address Dementia Risk (C-BBHP)

项目总结 当前第一阶段提案的目标是进一步制定(关键的试验准备情况)并评估 以社区为基础的脑健康计划应对痴呆症风险(C-BHP)，包括多种干预 影响饮食、运动和认知健康的方式旨在延长老年人的功能 独立性和提高认知能力。这种干预可能会使一大批人受益 脆弱的老年人，目前缺乏长期可行的治疗选择，有患痴呆症的风险。 痴呆症是美国最昂贵的疾病。目前，超过500万美国人患有痴呆症 被诊断为阿尔茨海默病(AD)，这是痴呆症最常见的形式，患病率正在扩大 我们的人口老龄化了。除了痴呆症对健康和生活质量的明显影响外，还有 高昂的经济成本。因此，实施可扩展的干预措施以防止功能依赖和 痴呆症对整体公共健康至关重要。 在这里，我们建议完成一个创新的多模式脑健康计划的开发和测试， 通过基督教青年会的广泛网络在社区管理。该计划由干预措施组成，以 改善有痴呆症风险患者的认知功能和增强功能能力。在完成时 这个项目，我们将有足够的结果数据，以支持大规模随机对照试验在阶段 II旨在确定该计划对有痴呆症风险的老年人的医疗效果。

PROJECT SUMMARY The goal of the current Phase I proposal is to further develop (to pivotal trial readiness) and evaluate a community-based Brain Health Program to address dementia risk (C-BBHP) that includes multiple intervention modalities affecting diet, exercise and cognitive health designed to extend older adults’ functional independence and improve cognitive performance. This intervention may benefit a large population of vulnerable older adults that are at risk for dementia with current lack of long-term viable treatment options. Dementia is the most expensive medical condition in the U.S. Presently, more than 5 million Americans are diagnosed with Alzheimer’s disease (AD), the most common form of dementia, and prevalence is expanding as our population ages. In addition to the obvious health and quality-of-life ramifications of dementia, there are high economic costs. Thus, implementing scalable interventions to prevent functional dependence and dementia is of critical importance to overall public health. Here, we propose to complete the development and testing of an innovative multimodal brain health program, administered in communities via the broad network of the YMCA. The program is comprised of interventions to improve cognitive function and bolster functional abilities in patients with dementia risk. At the completion of this project we will have outcomes data sufficient to support a large scale randomized controlled trial in Phase II designed to establish medical efficacy of this program for older adults with dementia risk.