Amplified Attention Training (AAT) for Age-related Cognitive Decline

描述（由申请人提供）：当前项目的目标是修改计算机化注意力训练程序（记忆通道放大注意力训练，M-AAT）的原型，该程序设计用于在I期完成的年龄相关认知衰退，并进行多中心，随机，对照试验，以确定在该人群中的疗效。作为一个群体， 与年龄相关的认知能力下降往往具有较差的长期预后，并且比没有类似下降的个体更可能需要管理式护理。我们最近的研究是第一批证明M-AAT，针对持续的注意力和认知控制，可以产生持久的好处。 本项目的总体目标是测量3个共同主要结果：注意力、执行功能和功能能力。我们第一阶段试验的证据表明，M-AAT可以改善注意力和执行功能。在本项目完成时，我们将获得足够的结局数据，以提交给FDA，作为适用于增强年龄相关认知下降（ICD-9代码R41.81）的认知的医疗器械进行批准。

DESCRIPTION (provided by applicant): The goal of the current project is to revise a prototype of a computerized attention training program (Memory Lane-Amplified Attention Training, M-AAT) designed for age-related cognitive decline completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. As a group, individuals with age-related cognitive decline tend to have poorer long-term prognosis and are more likely to require managed care than individuals without similar declines. Our recent studies are among the first to demonstrate that M-AAT, targeting sustained attention and cognitive control, can produce lasting benefits. The overall goal of the current project is to measure 3 co-primary outcomes: attention, executive function and functional capacity. Evidence from our Phase I trial shows that M-AAT can improve attention and executive function. At the completion of this project we will have outcomes data sufficient for submission to the FDA for clearance as a medical device indicated for cognitive enhancement in age-related cognitive decline (ICD-9 Code R41.81).