Characterizing resilience to food-cue induced overeating in children

表征儿童对食物暗示引起的暴饮暴食的抵抗力

• 批准号: 10394785
• 负责人: KATHLEEN L KELLER
• 金额: $ 57.5万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394785
• 关键词: 8 year old; Address; Advertisements; Advertising; Affect; Attention; Automobile Driving; Behavioral; Brain; Brain region; Characteristics; Child; Child Development; Code; Cognitive; Consumption; Corpus striatum structure; Cues; Data; Development; Dual-Energy X-Ray Absorptiometry; Eating; Eating Behavior; Energy Intake; Enrollment; Environment; Etiology; Event; Exhibits; Exposure to; Family; Food; Food Energy; Foundations; Hyperphagia; Image; Individual; Individual Differences; Laboratories; Literature; Machine Learning; Measures; Neurobiology; Obesity; Palate; Parents; Phenotype; Predisposition; Prefrontal Cortex; Prevention program; Prospective Studies; Public Health; Research; Resistance; Rewards; Risk; Science; Source; Speed; Structure of postcentral gyrus; Techniques; Testing; Toy; Weight; Weight Gain; approach behavior; base; behavioral outcome; behavioral phenotyping; behavioral response; cognitive control; critical period; design; eating in absence of hunger; excessive weight gain; executive function; experience; food consumption; food marketing; health goals; healthy weight; hedonic; high risk; neural circuit; neural network; novel; obesity development; obesity in children; obesity prevention; obesity risk; obesogenic; preadolescence; prevent; prospective; public health priorities; relating to nervous system; resilience; response; somatosensory; trait

Project Summary: While strong empirical evidence shows that exposure to food advertisements increases short-term food intake and contributes to the development of obesity, not all children are susceptible to this effect. Identifying the characteristics that protect some children from overeating in response to food advertising is a public health priority that may highlight novel targets for childhood obesity prevention. We propose to use state-of-the art, data driven techniques to identify neural, cognitive and behavioral phenotypes that are associated with resiliency to food-cue induced overeating and determine whether these phenotypes protect children from weight gain during the critical pre-adolescent period. The driving premise of this proposal is that children who are resistant to food-cue induced overeating will exhibit a distinct cluster of neural, behavioral, and cognitive traits which protect them from weight gain in an obesogenic environment. Our preliminary studies suggest that greater neural activation in prefrontal cortical regions implicated in cognitive control, increased executive functioning, and lower food advertising exposure may be some of the characteristics that confer resiliency to overeating in response to food advertising cues. To confirm our preliminary findings, we plan to enroll 140, 7-8 year-old children with healthy weight who vary by risk for obesity (70 low-risk/both parents with healthy weight; 70 high-risk/both parents with obesity) for a 1-year prospective study. In aim one, we will compare the effect of exposing children to commercials (i.e., food, toy, and non-rewarding advertisements) on subsequent neural activation and network connectivity characteristics in response to viewing high-energy food cues. We hypothesize that exposure to food commercials (vs. toy and non-food) will reduce prefrontal cortex activation, but that there will be substantial variability in this response across children. In aim two, we will determine how food commercials affect children’s subsequent food intake at both homeostatic (i.e., ad libitum test-meals) and non-homeostatic (i.e., eating palatable snacks when not hungry) eating events and relate these responses to underlying neural circuitry. In aim three, we will test the extent to which children’s executive function and prior food advertising experience moderate the relationship between food commercial exposure and subsequent neural and behavioral outcomes. In the final aim, we will use sophisticated data-driven techniques (i.e., machine learning) to identify neural, behavioral, and cognitive traits that moderate the effect of familial risk status on weight-gain. We expect the proposed studies to inform the science of obesity prevention by identifying specific modifiable phenotypes that protect high-risk children from excess weight gain during the pre-adolescent period. The overall impact of these studies will be to identify novel neural and behavioral characteristics of resiliency to food advertising in children. It will be the first to focus specifically on characterizing neural resiliency factors associated with decreased risk of food-cue induced eating and determine the extent to which these factors protect pre-adolescent children from the development of obesity.

项目摘要：虽然强有力的经验证据表明， 短期的食物摄入，并有助于肥胖的发展，并不是所有的孩子都容易受到这种影响 效果识别保护某些儿童不因食品广告而暴饮暴食的特征 是一个公共卫生优先事项，可能会突出儿童肥胖预防的新目标。我们建议使用 最先进的，数据驱动的技术，以确定神经，认知和行为表型， 与对食物线索诱导的暴饮暴食的弹性相关，并确定这些表型是否保护 儿童在青春期前的关键时期体重增加。这一提议的主要前提是， 对食物线索诱导的暴饮暴食有抵抗力的儿童将表现出一组明显的神经，行为， 以及认知特征，这些特征可以保护他们在致胖环境中免受体重增加的影响。我们的初步研究 这表明，与认知控制有关的前额叶皮层区域的神经激活增加， 执行功能，以及较低的食品广告曝光可能是一些特征，赋予 对食品广告暗示的反应过度饮食的弹性。为了证实我们的初步发现，我们计划 招募140名7-8岁体重健康的儿童，这些儿童因肥胖风险而异（70名低风险/父母双方均患有肥胖症）。 健康体重; 70名高风险/父母均患有肥胖症）进行为期1年的前瞻性研究。在目标一，我们将 比较儿童接触商业广告的效果（即，食品、玩具和非奖励性广告） 随后的神经激活和网络连接特性响应于观看高能量食物 线索我们假设，暴露于食品广告（与玩具和非食品）将减少前额叶皮层 激活，但儿童的这种反应会有很大的差异。在目标二中，我们将 确定食品广告如何影响儿童随后的食物摄入量，随意 试验餐）和非稳态（即，不饿时吃可口的零食）进食事件， 这些对潜在神经回路的反应在目标三中，我们将测试儿童的执行力在多大程度上 功能和先前的食品广告经验调节食品商业暴露之间的关系 以及随后的神经和行为结果。最终，我们将使用复杂的数据驱动 技术（即，机器学习），以识别调节 体重增加的家族风险状况。我们希望拟议的研究能为肥胖预防科学提供信息 通过识别特定的可改变的表型，保护高危儿童免受过度体重增加， 青春期前这些研究的总体影响将是确定新的神经和行为 儿童对食品广告的弹性特征。它将是第一个专门关注 表征与食物线索诱导进食风险降低相关的神经弹性因素， 确定这些因素在多大程度上保护青春期前儿童免受肥胖的发展。