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Characterizing resilience to food-cue induced overeating in children

表征儿童对食物暗示引起的暴饮暴食的抵抗力

基本信息

批准号：
10608956
负责人：
KATHLEEN L KELLER
金额：
$ 57.07万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10608956
关键词：
8 year old Address Advertisements Advertising Affect Attention Automobile Driving Behavioral Brain Brain region Characteristics Child Child Development Code Cognitive Consumption Corpus striatum structure Cues Data Development Dual-Energy X-Ray Absorptiometry Eating Eating Behavior Energy Intake Enrollment Environment Etiology Event Exhibits Exposure to Family Food Food Energy Foundations Hyperphagia Image Individual Individual Differences Laboratories Literature Machine Learning Measures Neurobiology Obesity Parents Phenotype Predisposition Prefrontal Cortex Prevention program Prospective Studies Public Health Research Resistance Rewards Risk Science Source Speed Structure of postcentral gyrus Techniques Testing Toy Weight Weight Gain approach behavior behavioral outcome behavioral phenotyping behavioral response cognitive control critical period design eating in absence of hunger excessive weight gain executive function experience food consumption food marketing health goals healthy weight hedonic high risk neural neural circuit neural network novel obesity development obesity in children obesity prevention obesity risk obesogenic preadolescence prevent prospective public health priorities resilience resilience factor response somatosensory trait

项目摘要

Project Summary: While strong empirical evidence shows that exposure to food advertisements increases short-term food intake and contributes to the development of obesity, not all children are susceptible to this effect. Identifying the characteristics that protect some children from overeating in response to food advertising is a public health priority that may highlight novel targets for childhood obesity prevention. We propose to use state-of-the art, data driven techniques to identify neural, cognitive and behavioral phenotypes that are associated with resiliency to food-cue induced overeating and determine whether these phenotypes protect children from weight gain during the critical pre-adolescent period. The driving premise of this proposal is that children who are resistant to food-cue induced overeating will exhibit a distinct cluster of neural, behavioral, and cognitive traits which protect them from weight gain in an obesogenic environment. Our preliminary studies suggest that greater neural activation in prefrontal cortical regions implicated in cognitive control, increased executive functioning, and lower food advertising exposure may be some of the characteristics that confer resiliency to overeating in response to food advertising cues. To confirm our preliminary findings, we plan to enroll 140, 7-8 year-old children with healthy weight who vary by risk for obesity (70 low-risk/both parents with healthy weight; 70 high-risk/both parents with obesity) for a 1-year prospective study. In aim one, we will compare the effect of exposing children to commercials (i.e., food, toy, and non-rewarding advertisements) on subsequent neural activation and network connectivity characteristics in response to viewing high-energy food cues. We hypothesize that exposure to food commercials (vs. toy and non-food) will reduce prefrontal cortex activation, but that there will be substantial variability in this response across children. In aim two, we will determine how food commercials affect children’s subsequent food intake at both homeostatic (i.e., ad libitum test-meals) and non-homeostatic (i.e., eating palatable snacks when not hungry) eating events and relate these responses to underlying neural circuitry. In aim three, we will test the extent to which children’s executive function and prior food advertising experience moderate the relationship between food commercial exposure and subsequent neural and behavioral outcomes. In the final aim, we will use sophisticated data-driven techniques (i.e., machine learning) to identify neural, behavioral, and cognitive traits that moderate the effect of familial risk status on weight-gain. We expect the proposed studies to inform the science of obesity prevention by identifying specific modifiable phenotypes that protect high-risk children from excess weight gain during the pre-adolescent period. The overall impact of these studies will be to identify novel neural and behavioral characteristics of resiliency to food advertising in children. It will be the first to focus specifically on characterizing neural resiliency factors associated with decreased risk of food-cue induced eating and determine the extent to which these factors protect pre-adolescent children from the development of obesity.

项目概述：虽然强有力的经验证据表明，接触食品广告的机会增加短期食物摄入并有助于肥胖的发展，并不是所有的儿童都容易受此影响效果。针对食品广告确定保护部分儿童不暴饮暴食的特征是一项公共卫生优先事项，可能会突出儿童肥胖预防的新目标。我们建议使用最先进的数据驱动技术，用于识别符合以下条件的神经、认知和行为表型与食物诱导的暴饮暴食的弹性相关，并确定这些表型是否儿童在关键的青春期前体重增加。这项提议的主要前提是对食物提示诱导的暴食产生抵抗力的儿童将表现出明显的神经，行为，以及在肥胖环境中保护他们免受体重增加的认知特征。我们的初步研究这表明，与认知控制有关的前额叶皮质区域更大的神经激活增加了执行功能，以及较低的食品广告曝光率可能是赋予这些功能的一些特征对食物广告提示做出反应的暴饮暴食的弹性。为了确认我们的初步调查结果，我们计划招募体重正常、肥胖风险不同的140名7-8岁儿童(70名低风险/父母均有健康体重；70名高风险/父母都患有肥胖症)，进行为期一年的前瞻性研究。在目标一中，我们将比较让儿童接触商业广告(即食品、玩具和非有利可图的广告)对响应于观看高能食物的后续神经激活和网络连接特征暗示。我们假设，接触食品广告(与玩具和非食品相比)会减少前额叶皮质。这种反应在不同的儿童中会有很大的差异。在目标二中，我们将确定食品广告如何影响儿童在两种状态下的后续食物摄入量(即随意试餐)和非稳态(即在不饿的时候吃可口的零食)的进食事件和联系这些对潜在神经回路的反应。在目标三中，我们将测试儿童执行力的程度功能和之前的食品广告经验对食品商业曝光率之间的关系起到调节作用以及随后的神经和行为结果。在最终目标中，我们将使用复杂的数据驱动识别神经、行为和认知特征的技术(即，机器学习)，这些特征可以缓和体重增加的家庭危险状况。我们期望这些拟议的研究能够为肥胖预防提供科学依据。通过确定特定的可改变的表型来保护高危儿童在青春期前。这些研究的总体影响将是确定新的神经和行为儿童对食品广告的复原力特征。它将是第一个专门关注表征神经弹性因素与食物线索诱导的进食和饮食风险降低相关确定这些因素在多大程度上保护青春期前儿童免受肥胖的影响。