Yale Cancer Biology Training Grant

耶鲁大学癌症生物学培训补助金

• 批准号: 10394345
• 负责人: PETER M GLAZER
• 金额: $ 40.59万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-20 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394345
• 关键词: Cancer Biology; Grant; Training

Recent advances in understanding cancer, combined with unprecedented access to patient DNA sequence data, and new rational therapeutic approaches create the need for a revolution in Ph.D. training of cancer scientists. The Yale Cancer Biology Training Program takes advantage of the high caliber of biologists at Yale, the commitment to multidisciplinary training in the life sciences, and the close collaboration of Yale cancer biologists and clinicians fostered by the Yale Cancer Center to provide a cancer-focused training experience that is intended to spawn the next generation of cancer scientific leaders. This program is the only cancer-focused PhD training program at Yale and is also unusual in the extent of exposure to clinical concepts and practice. Training will cover the genetic and biological underpinnings of cancer, the pathway to development of new therapies based upon this knowledge, and the practical challenges in applying these new therapies in cancer clinics. Predoctoral trainees will be trained in foundational biological areas through course work in fundamental areas including biology, genetics, computational biology, and pathophysiology and join the program in the second year of graduate school. Postdoctoral fellows will join the program early in postdoctoral training. All trainees will spend 90% of their time in laboratory research projects mentored by highly qualified faculty who are leaders in disciplines of cancer research including tumor virology, cancer immunobiology, cancer genetics and epigenetics, stem cell research, metabolism, pharmacology, and signal transduction. This two-year program will train up to 30 predoctoral and postdoctoral trainees each year (including first and second year trainees). Funding for two predoctoral and six postdoctoral trainees will be supported by this training grant. For predoctoral trainees, the training experience will include three research rotations and didactic and seminar courses and continue with qualifying examinations and written dissertation in a projected period of five years overall. Postdoctoral training includes participation in program coursework and other program activities. All trainees are supervised by faculty committees that meet annually to evaluate research progress and promote training goals and career development. Cancer-specific training provided for all trainees will include three formal courses: 1. a general survey class covering basic principles of cancer biology and genetics; 2. Advanced Topics in Cancer workshop in which selected topics are analyzed and discussed in depth; 3. Cancer Clinical Translation, including practical clinical translation, clinical trials, and patient treatment patterns and clinical questions for major diseases. Multiple options are provided for training in Immuno- Oncology, depending on prior immunology background. Other program elements include Precision Medicine Tumor Board (discussion of cases in the context of whole genome tumor sequence), Yale Cancer Center Grand Rounds and Program Meetings, and Cancer Biology Training Program meetings. Every trainee will have a clinical mentor to foster exposure to clinical concepts through tumor boards and clinics.

了解癌症的最新进展，以及对患者 DNA 的前所未有的获取 序列数据和新的合理治疗方法创造了对博士学位革命的需求。的培训 癌症科学家。耶鲁大学癌症生物学培训计划充分利用高素质生物学家的优势 在耶鲁大学，对生命科学多学科培训的承诺以及耶鲁大学的密切合作 耶鲁大学癌症中心培养的癌症生物学家和临床医生提供以癌症为重点的培训 旨在培养下一代癌症科学领袖的经验。这个程序是唯一的 耶鲁大学以癌症为重点的博士培训项目，在接触临床概念的程度上也不同寻常 并练习。培训将涵盖癌症的遗传和生物学基础、癌症的途径 基于这些知识的新疗法的开发，以及应用这些新疗法的实际挑战 癌症诊所的治疗。博士前培训生将通过课程接受基础生物学领域的培训 在生物学、遗传学、计算生物学和病理生理学等基础领域工作，并加入 研究生院第二年的课程。博士后研究员将在博士后早期加入该计划 训练。所有学员将花费 90% 的时间在高素质导师的指导下进行实验室研究项目 癌症研究学科的领导者，包括肿瘤病毒学、癌症免疫生物学、 癌症遗传学和表观遗传学、干细胞研究、代谢、药理学和信号转导。 该项目为期两年，每年将培养多达30名博士前和博士后学员（包括第一批博士后） 和第二年的实习生）。该项目将支持两名博士前培训生和六名博士后培训生的资助 培训补助金。对于博士前培训生来说，培训经历将包括三次研究轮转和 教学和研讨会课程，并继续进行资格考试和书面论文 总体期限为五年。博士后培训包括参与项目课程和其他 计划活动。所有学员均受到教职委员会的监督，该委员会每年举行一次会议以评估研究 进步并促进培训目标和职业发展。为所有学员提供针对癌症的培训 将包括三门正式课程： 1. 涵盖癌症生物学基本原理和 遗传学； 2. 癌症高级主题研讨会，其中对所选主题进行分析和讨论 深度; 3. 癌症临床翻译，包括实用临床翻译、临床试验和患者治疗 主要疾病的模式和临床问题。提供多种选项用于免疫培训 肿瘤学，取决于先前的免疫学背景。其他计划内容包括精准医学 肿瘤委员会（在全基因组肿瘤序列背景下讨论病例），耶鲁大学癌症中心 大型查房和计划会议以及癌症生物学培训计划会议。每个实习生都会有 临床导师，通过肿瘤委员会和诊所促进临床概念的接触。