Yale Cancer Biology Training Grant

耶鲁大学癌症生物学培训补助金

• 批准号: 10170726
• 负责人: PETER M GLAZER
• 金额: $ 44.14万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-20 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10170726
• 关键词: Cancer Biology; Grant; Training

Recent advances in understanding cancer, combined with unprecedented access to patient DNA sequence data, and new rational therapeutic approaches create the need for a revolution in Ph.D. training of cancer scientists. The Yale Cancer Biology Training Program takes advantage of the high caliber of biologists at Yale, the commitment to multidisciplinary training in the life sciences, and the close collaboration of Yale cancer biologists and clinicians fostered by the Yale Cancer Center to provide a cancer-focused training experience that is intended to spawn the next generation of cancer scientific leaders. This program is the only cancer-focused PhD training program at Yale and is also unusual in the extent of exposure to clinical concepts and practice. Training will cover the genetic and biological underpinnings of cancer, the pathway to development of new therapies based upon this knowledge, and the practical challenges in applying these new therapies in cancer clinics. Predoctoral trainees will be trained in foundational biological areas through course work in fundamental areas including biology, genetics, computational biology, and pathophysiology and join the program in the second year of graduate school. Postdoctoral fellows will join the program early in postdoctoral training. All trainees will spend 90% of their time in laboratory research projects mentored by highly qualified faculty who are leaders in disciplines of cancer research including tumor virology, cancer immunobiology, cancer genetics and epigenetics, stem cell research, metabolism, pharmacology, and signal transduction. This two-year program will train up to 30 predoctoral and postdoctoral trainees each year (including first and second year trainees). Funding for two predoctoral and six postdoctoral trainees will be supported by this training grant. For predoctoral trainees, the training experience will include three research rotations and didactic and seminar courses and continue with qualifying examinations and written dissertation in a projected period of five years overall. Postdoctoral training includes participation in program coursework and other program activities. All trainees are supervised by faculty committees that meet annually to evaluate research progress and promote training goals and career development. Cancer-specific training provided for all trainees will include three formal courses: 1. a general survey class covering basic principles of cancer biology and genetics; 2. Advanced Topics in Cancer workshop in which selected topics are analyzed and discussed in depth; 3. Cancer Clinical Translation, including practical clinical translation, clinical trials, and patient treatment patterns and clinical questions for major diseases. Multiple options are provided for training in Immuno- Oncology, depending on prior immunology background. Other program elements include Precision Medicine Tumor Board (discussion of cases in the context of whole genome tumor sequence), Yale Cancer Center Grand Rounds and Program Meetings, and Cancer Biology Training Program meetings. Every trainee will have a clinical mentor to foster exposure to clinical concepts through tumor boards and clinics.

了解癌症的最新进展，以及前所未有的获取患者DNA的途径 序列数据和新的合理的治疗方法创造了对博士培养的革命的需要 癌症科学家。耶鲁大学癌症生物学培训项目利用高素质的生物学家 在耶鲁，对生命科学多学科培训的承诺，以及耶鲁的密切合作 由耶鲁癌症中心培养的癌症生物学家和临床医生提供以癌症为重点的培训 这一经验旨在孕育下一代癌症科学领袖。这个项目是唯一一个 耶鲁大学以癌症为重点的博士培训计划，在接触临床概念的程度上也是不同寻常的 和练习。培训将涵盖癌症的遗传和生物学基础，即 基于这些知识的新疗法的开发，以及应用这些新疗法面临的实际挑战 癌症诊所的治疗方法。博士前实习生将通过课程接受基础生物学领域的培训 在生物学、遗传学、计算生物学和病理生理学等基础领域工作，并加入 研究生院二年级的课程。博士后研究员将在博士后早期加入该项目 训练。所有受训人员将把90%的时间用于由高资质人员指导的实验室研究项目 是癌症研究学科的领导者，包括肿瘤病毒学、癌症免疫生物学、 癌症遗传学和表观遗传学、干细胞研究、新陈代谢、药理学和信号转导。 这一为期两年的计划每年将培训多达30名博士后和博士后学员(包括第一批 和二年级实习生)。两名博士后和六名博士后实习生的资金将由该基金提供支持 培训补助金。对于博士前实习生，培训经验将包括三次研究轮换和 授课和研讨会课程，继续进行资格考试和计划中的书面论文 总共五年的时间。博士后培训包括参与项目课程和其他 计划活动。所有受训人员都由教员委员会监督，这些委员会每年开会评估研究。 改进和促进培训目标和职业发展。为所有学员提供针对癌症的培训 将包括三门正式课程：1.癌症生物学基本原理概论课程； 遗传学；2.癌症高级主题研讨会，在研讨会中分析和讨论选定的主题 深度；3.癌症临床翻译，包括实用的临床翻译、临床试验和患者治疗 重大疾病的模式和临床问题。为免疫培训提供多种选择 肿瘤学，取决于先前的免疫学背景。其他计划内容包括Precision Medicine 肿瘤委员会(全基因组肿瘤序列背景下的病例讨论)，耶鲁癌症中心 大型巡回会议和计划会议，以及癌症生物学培训计划会议。每个实习生都将拥有 一位临床导师，通过肿瘤委员会和诊所培养接触临床概念。