Yale Cancer Biology Training Grant

耶鲁大学癌症生物学培训补助金

• 批准号: 10170726
• 负责人: PETER M GLAZER
• 金额: $ 44.14万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-20 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10170726
• 关键词: Cancer Biology; Grant; Training

Recent advances in understanding cancer, combined with unprecedented access to patient DNA sequence data, and new rational therapeutic approaches create the need for a revolution in Ph.D. training of cancer scientists. The Yale Cancer Biology Training Program takes advantage of the high caliber of biologists at Yale, the commitment to multidisciplinary training in the life sciences, and the close collaboration of Yale cancer biologists and clinicians fostered by the Yale Cancer Center to provide a cancer-focused training experience that is intended to spawn the next generation of cancer scientific leaders. This program is the only cancer-focused PhD training program at Yale and is also unusual in the extent of exposure to clinical concepts and practice. Training will cover the genetic and biological underpinnings of cancer, the pathway to development of new therapies based upon this knowledge, and the practical challenges in applying these new therapies in cancer clinics. Predoctoral trainees will be trained in foundational biological areas through course work in fundamental areas including biology, genetics, computational biology, and pathophysiology and join the program in the second year of graduate school. Postdoctoral fellows will join the program early in postdoctoral training. All trainees will spend 90% of their time in laboratory research projects mentored by highly qualified faculty who are leaders in disciplines of cancer research including tumor virology, cancer immunobiology, cancer genetics and epigenetics, stem cell research, metabolism, pharmacology, and signal transduction. This two-year program will train up to 30 predoctoral and postdoctoral trainees each year (including first and second year trainees). Funding for two predoctoral and six postdoctoral trainees will be supported by this training grant. For predoctoral trainees, the training experience will include three research rotations and didactic and seminar courses and continue with qualifying examinations and written dissertation in a projected period of five years overall. Postdoctoral training includes participation in program coursework and other program activities. All trainees are supervised by faculty committees that meet annually to evaluate research progress and promote training goals and career development. Cancer-specific training provided for all trainees will include three formal courses: 1. a general survey class covering basic principles of cancer biology and genetics; 2. Advanced Topics in Cancer workshop in which selected topics are analyzed and discussed in depth; 3. Cancer Clinical Translation, including practical clinical translation, clinical trials, and patient treatment patterns and clinical questions for major diseases. Multiple options are provided for training in Immuno- Oncology, depending on prior immunology background. Other program elements include Precision Medicine Tumor Board (discussion of cases in the context of whole genome tumor sequence), Yale Cancer Center Grand Rounds and Program Meetings, and Cancer Biology Training Program meetings. Every trainee will have a clinical mentor to foster exposure to clinical concepts through tumor boards and clinics.

了解癌症的最新进展，以及前所未有的患者DNA获取 序列数据和新的合理的治疗方法创造了一个革命的博士学位的需要。培训 癌症科学家耶鲁大学癌症生物学培训计划利用高素质的生物学家 在耶鲁大学，致力于生命科学的多学科培训，以及耶鲁大学的密切合作， 由耶鲁癌症中心培养的癌症生物学家和临床医生提供以癌症为重点的培训， 这一经验旨在培养下一代癌症科学领导者。这个项目是唯一 耶鲁大学以癌症为重点的博士培训项目，在接触临床概念的程度上也是不寻常的 和实践培训将涵盖癌症的遗传和生物学基础， 基于这些知识的新疗法的开发，以及应用这些新疗法的实际挑战， 癌症诊所的治疗方法。博士前学员将通过课程在基础生物领域进行培训 在基础领域工作，包括生物学，遗传学，计算生物学和病理生理学，并加入 研究生院第二年的课程。博士后研究员将在博士后早期加入该计划 训练所有学员将花费90%的时间在实验室研究项目上，由高素质的 教师谁是癌症研究的学科，包括肿瘤病毒学，癌症免疫生物学， 癌症遗传学和表观遗传学、干细胞研究、代谢、药理学和信号转导。 这个为期两年的项目每年将培养多达30名博士前和博士后学员（包括第一批 第二年的实习生）。资助两名博士前和六名博士后学员将得到支持， 培训补助金。对于博士前学员，培训经验将包括三个研究轮换， 教学和研讨会课程，并继续与资格考试和书面论文在一个预计 整个五年。博士后培训包括参与计划课程和其他 方案活动。所有学员都由教师委员会监督，每年开会评估研究 进步和促进培训目标和职业发展。为所有学员提供癌症专门培训 将包括三个正式课程：1。一个涵盖癌症生物学基本原理的普查班， 遗传学; 2.癌症高级主题研讨会，其中选定的主题进行了分析和讨论， 深度; 3.癌症临床翻译，包括实用临床翻译、临床试验和患者治疗 主要疾病的模式和临床问题。为免疫学培训提供了多种选择- 肿瘤学，取决于先前的免疫学背景。其他计划要素包括精准医学 肿瘤委员会（在全基因组肿瘤序列背景下讨论病例），耶鲁癌症中心 大型圆桌会议和项目会议，以及癌症生物学培训项目会议。每一位学员都将拥有 临床导师，通过肿瘤委员会和诊所促进接触临床概念。