Training Grant in Cancer Biology

项目摘要/摘要 我们的癌症生物学培训补助金的目标是教育博士前学员和博士后研究员， 成为下一代癌症研究人员，克服癌症研究中的最大挑战。这 该计划将为受训者提供教育和培训机会，使他们能够融入 多种尖端方法和技术。我们的计划高度集中在信号 癌细胞网络、肿瘤微环境、转移以及癌细胞与宿主之间的相互作用 细胞培训包括最先进的主题和方法，包括细胞外囊泡，代谢组学， microRNA生物学我们的计划导师在资助和出版方面都有出色的记录， 高影响力期刊所有这些都有与癌症直接相关的同行评审研究支持;因此， 该计划满足并超过了NCI计划要求的最低50%的导师有同行， 审查癌症研究支持。计划导师持有约23，629，683美元的总校外研究 资金，其中约15，401，301美元（约65%）由NIH提供。一个由七名成员组成的内部执行官 委员会（IEC）将评估有兴趣加入该计划的潜在导师，以及目前的导师， 在融资期间。此外，四个小组委员会（教育、科学行为、务虚会/专题讨论会） 将协助IEC和项目主任/联合主任促进与项目有关的职能， 工作坊.根据对培训计划的申请，一个由五名成员组成的教育小组委员会将选出 潜在的候选人（两名博士前实习生和六名博士后研究员），并通过程序面试后， 学院，将提交最终的实习生名单，以IEC批准，沿着两个额外的博士前实习生 由德克萨斯大学医学博士安德森癌症中心的教务长支持。每一位学员都要完成 2年的培训计划，并将有一个个人发展计划在1个月内进入 程序.博士前学员遵循德克萨斯大学研究生院的指导方针， 生物医学科学，而博士后学员必须在第一个完成两个核心课程 一年，两年内举办三次研讨会。所有学员都必须1）参加特定的课程 本文件概述的讲习班和活动; 2）在内部举行四次常设咨询/指导委员会会议， 2年培训期; 3）提交咨询/指导委员会评估的年度进度报告。所有 受训人员每年将至少参加四次一小时的RCR讲习班，高级受训人员的后续工作将 确保每四年进行一次再培训。该计划将由外部咨询委员会/内部 咨询委员会成员，学员，导师和校友关于当前的方法和考虑， 创新的建议。培训完成后，计划的学员将有能力融入 涵盖癌症科学所有相关领域的多个不同学科。

Project Abstract/Summary The goal of our Training Grant in Cancer Biology is to educate predoctoral trainees and postdoctoral fellows to be the next generation of cancer researchers and overcome the greatest challenges in cancer research. This Program will provide trainees with educational and training opportunities that will allow them to assimilate multiple cutting-edge methodologies and technologies. Our program has highly directed foci on signaling networks in cancer cells, tumor microenvironment, metastasis and interactions between cancer cells and host cells. Training includes state-of-the-art topics and methodologies including extracellular vesicles, metabolomics, and microRNA biology. Our Program mentors have outstanding track records in both funding and publication in high-impact journals. All of them have peer-reviewed research support directly related to cancer; thus this program fulfills and exceeds the NCI Programmatic Requirement minimum of 50% of mentors having peer- reviewed cancer research support. Program mentors hold about $23,629,683 in total extramural research funding, of which about $15,401,301 (~65%) is provided by the NIH. A seven-member Internal Executive Committee (IEC) will evaluate potential mentors interested in joining the program, as well as current mentors, during the funding period. In addition, four subcommittees (Education, Science Conduct, Retreat/Symposium and Diversity) will assist the IEC and Program Director/Co-director in facilitating program-related functions and workshops. Based on applications to the training program, a five-member Education Subcommittee will select potential candidates (two predoctoral trainees and six postdoctoral fellows) and, after interview by Program Faculty, will submit the final trainee list to the IEC for approval, along with two additional predoctoral trainees supported by the Provost at The University of Texas MD Anderson Cancer Center. Each trainee will complete 2 years of training in the Program and will have an Individual Development Plan within 1 month of entering the Program. The predoctoral trainees follow the guidelines of The University of Texas Graduate School of Biomedical Sciences, whereas the postdoctoral trainees are required to complete two core courses in the first year and three seminar courses within two years. All trainees are required to 1) enroll in program-specific workshops and activities outlined herein; 2) have four standing advisory/mentoring committee meetings within the 2-year training period; 3) submit an annual progress report evaluated by advisory/mentoring committee. All trainees will have at least four one-hour RCR workshops each year, and follow-up for senior trainees will be done to ensure retraining every 4 years. The Program will be evaluated by external advisory board/internal advisory board members, trainees, mentors, and alumni regarding current approaches and consideration of innovative suggestions. Upon completion of the training, Program's trainees will have the ability to integrate multiple, diverse disciplines that encompass all relevant areas in cancer science.