Training Grant in Cancer Biology

项目摘要/摘要 我们癌症生物学培训助学金的目标是教育博士后实习生和博士后研究员 成为下一代癌症研究人员，克服癌症研究中的最大挑战。这 该计划将为学员提供教育和培训机会，使他们能够 多种尖端方法和技术。我们的节目高度关注信号 癌细胞网络、肿瘤微环境、转移以及癌细胞与宿主之间的相互作用 细胞。培训包括最新的主题和方法，包括细胞外小泡，代谢组学， 和微核糖核酸生物学。我们的计划导师在资助和出版方面都有出色的记录 影响力很大的期刊。他们所有人都有与癌症直接相关的同行评议研究支持；因此， 计划满足并超过NCI计划要求，至少有50%的导师具有同行- 回顾了对癌症研究的支持。项目导师总共拥有约23,629,683美元的校外研究 资金，其中约15,401,301美元(~65%)由美国国立卫生研究院提供。七人内部高管 委员会(IEC)将评估有兴趣加入该计划的潜在导师，以及现有的导师， 在筹资期间。此外，还有四个小组委员会(教育、科学行为、务虚会/专题讨论会 和多样性)将协助IEC和计划主任/联席主任促进与计划相关的职能和 研讨会。根据培训计划的申请，一个由五名成员组成的教育小组委员会将选择 潜在候选人(两名博士后实习生和六名博士后研究员)，并在项目面试后 教师将提交最终的实习生名单，以供IEC批准，同时还将提交另外两名博士前实习生 由德克萨斯大学MD安德森癌症中心教务长支持。每个实习生都要完成 在该计划中接受2年的培训，并将在进入该计划后的1个月内制定个人发展计划 程序。博士前实习生遵循德克萨斯大学研究生院的指导方针 生物医学，而博士后实习生需要在第一个月完成两门核心课程 在两年内提供一年和三个研讨会课程。所有受训人员必须1)登记参加特定计划 本文件概述的讲习班和活动；2)有四次常设咨询/指导委员会会议 2年的培训期；3)提交咨询/指导委员会评估的年度进度报告。全 学员每年将有至少四个一小时的RCR工作坊，高级学员的后续工作将是 确保每4年进行一次再培训。该计划将由外部顾问委员会/内部进行评估 咨询委员会成员、实习生、导师和校友关于当前的方法和考虑 创新建议。完成培训后，该计划的学员将有能力融入 涵盖癌症科学所有相关领域的多个不同学科。

Project Abstract/Summary The goal of our Training Grant in Cancer Biology is to educate predoctoral trainees and postdoctoral fellows to be the next generation of cancer researchers and overcome the greatest challenges in cancer research. This Program will provide trainees with educational and training opportunities that will allow them to assimilate multiple cutting-edge methodologies and technologies. Our program has highly directed foci on signaling networks in cancer cells, tumor microenvironment, metastasis and interactions between cancer cells and host cells. Training includes state-of-the-art topics and methodologies including extracellular vesicles, metabolomics, and microRNA biology. Our Program mentors have outstanding track records in both funding and publication in high-impact journals. All of them have peer-reviewed research support directly related to cancer; thus this program fulfills and exceeds the NCI Programmatic Requirement minimum of 50% of mentors having peer- reviewed cancer research support. Program mentors hold about $23,629,683 in total extramural research funding, of which about $15,401,301 (~65%) is provided by the NIH. A seven-member Internal Executive Committee (IEC) will evaluate potential mentors interested in joining the program, as well as current mentors, during the funding period. In addition, four subcommittees (Education, Science Conduct, Retreat/Symposium and Diversity) will assist the IEC and Program Director/Co-director in facilitating program-related functions and workshops. Based on applications to the training program, a five-member Education Subcommittee will select potential candidates (two predoctoral trainees and six postdoctoral fellows) and, after interview by Program Faculty, will submit the final trainee list to the IEC for approval, along with two additional predoctoral trainees supported by the Provost at The University of Texas MD Anderson Cancer Center. Each trainee will complete 2 years of training in the Program and will have an Individual Development Plan within 1 month of entering the Program. The predoctoral trainees follow the guidelines of The University of Texas Graduate School of Biomedical Sciences, whereas the postdoctoral trainees are required to complete two core courses in the first year and three seminar courses within two years. All trainees are required to 1) enroll in program-specific workshops and activities outlined herein; 2) have four standing advisory/mentoring committee meetings within the 2-year training period; 3) submit an annual progress report evaluated by advisory/mentoring committee. All trainees will have at least four one-hour RCR workshops each year, and follow-up for senior trainees will be done to ensure retraining every 4 years. The Program will be evaluated by external advisory board/internal advisory board members, trainees, mentors, and alumni regarding current approaches and consideration of innovative suggestions. Upon completion of the training, Program's trainees will have the ability to integrate multiple, diverse disciplines that encompass all relevant areas in cancer science.