Georgetown-Howard Universities Center for Clinical and Translational Science (GHU

乔治敦-霍华德大学临床和转化科学中心（GHUCCTS）是一个 乔治城大学（GU）和霍华德大学（HU）的主要合作伙伴，拥有3家附属医院 系统和研究机构：MedStar健康和研究所（MSH/MRI），橡树岭国家 实验室（ORNL）和华盛顿，DC退伍军人事务医疗中心（WVAMC）。本申请是 重新提交2008年修改后的申请。GHUCCTS的具体目标是： 通过激励创新、多学科和跨机构，加速改善人类健康 GHUCCTS研究者之间的研究; 2）支持临床和翻译的职业生涯 通过各种各样的教学教育计划，再加上有针对性的指导调查;和 3)加强对服务不足人群的临床和转化研究，无论是在华盛顿特区 地区和国家，主要包括少数民族，老年人和残疾人。完成这些 目标，我们将整合我们现有的NCRR资助的计划，包括两个现有的MOI资助的GCRC， GU和HU以及我们成功的多机构K30计划，拥有一家新的创新医院，实践- 以实验室为基础，以社区为基础的临床和转化科学研究基础设施。 作为GHUCCTS的一部分，我们将建立的新能力包括协调的多机构 生物医学信息学基础设施，一个扩大的临床研究运作，将创造新的 基于社区的临床研究单位，一个新的社区参与资源组成部分，以支持和 加强以社区为基础的研究，扩大监管知识的资源，并支持 与伦理学密切结合，以及新资助的研究项目，以开发新的翻译 与超级计算和系统遗传学翻译能力合作的方法， ORNL。这些临床和翻译资源在GHUCCTS机构的整合将是 伴随着强大的研究教育，培训和职业发展计划，将培养一个新的 新一代的研究人员，包括一个新的临床和转化学者K12计划和一个新的 临床与转化科学硕士学位课程。我们创新的合作方式， 涉及本地区多个主要研究密集型机构的多学科研究， 与国家CTSA网络的合作，将有助于我们在华盛顿的机构和社区， DC地区受益于临床和转化科学新发现的产生和应用。 相关性（参见说明）：

The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is a primary partnership of Georgetown University (GU) and Howard University (HU), with 3 affiliated hospital systems and research institutes: MedStar Health and Research Institute (MSH/MRI), Oak Ridge National Laboratory (ORNL), and the Washington, DC Veteran's Affairs Medical Center (WVAMC). This application is a resubmission of a revised previous application from 2008. The specific aims of GHUCCTS are: 1) To speed improvements in human health by stimulating innovative, multidisciplinary, and cross-institutional research among the GHUCCTS investigators; 2) To support the careers of clinical and translational investigators through a wide variety of didactic educational programs coupled with focused mentorship; and 3) To enhance clinical and translational research on underserved populations, both in the Washington DC region and nationally, prominently including minorities, the aged, and the disabled. To accomplish these aims, we will integrate our existing NCRR-funded programs, including two existing MOI-funded GCRCs at GU and HU and our successful multi-institutional K30 program, with a new and innovative hospital, practice- based, laboratory-based, and community-based research infrastructure for clinical and translational science. The new capabilities that we will build as part of GHUCCTS include a coordinated multi-institutional biomedical informatics infrastructure, an expanded clinical research operation that will create new community-based clinical research units, a new community engagement resource component to support and enhance community-based research, expanded resources in regulatory knowledge and support that will be intimately integrated with ethics, and new funded research projects in the development of novel translational methodologies in collaboration with the supercomputing and systems genetics translational capabilities of ORNL. The integration of these clinical and translational resources across the GHUCCTS institutions will be accompanied by a strong research education, training, and career development program that will train a new generation of researchers, including a new Clinical and Translational Scholars K12 program and a new Masters degree program in clinical and translational science. Our innovative approach to collaboration and multi-disciplinary research involving multiple major research-intensive institutions of our region, in collaboration with the national CTSA network, will help our institutions and our community in the Washington, DC area benefit from the generation and application of new discoveries in clinical and translational science. RELEVANCE (See instructions):