Alcohol-induced skeletal muscle dysregulation in SIV/HIV: Mitochondrial-mediated mechanisms

酒精引起的 SIV/HIV 骨骼肌失调：线粒体介导的机制

• 批准号: 10396702
• 负责人: Danielle E Levitt
• 金额: $ 2.27万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10396702
• 关键词: Alcohol consumption; Alcohols; Biogenesis; COVID-19 pandemic; Chronic; Data; Fellowship; Female; Foundations; Functional disorder; Funding; Future; General Population; HIV; HIV therapy; Health; Homeostasis; Individual; Intervention; Macaca mulatta; Manuscripts; Mediating; Metabolic; Mitochondria; Molecular; Muscle Mitochondria; Myoblasts; National Research Service Awards; PPAR gamma; Preparation; Publishing; Research; Risk; SIV; Skeletal Muscle; Testing; Therapeutic Intervention; Time; Virus Diseases; Work; alcohol risk; alcohol testing; antiretroviral therapy; base; comorbidity; improved; lifestyle intervention; mitochondrial dysfunction; receptor; therapeutic development; therapeutic target; translational study

Project summary The purpose of this supplement is to provide additional time for the completion of the NRSA individual fellowship titled “Alcohol-induced skeletal muscle dysregulation in SIV/HIV: Mitochondrial-mediated mechanisms”, F32AA027982 after significant disruption due to the COVID-19 pandemic. At-risk alcohol use among people living with HIV (PLWH) is nearly twice that in the general population. Chronic at-risk alcohol use and HIV/SIV are independently associated with metabolic comorbidities including skeletal muscle (SKM) dysfunction. Based on our published and preliminary data, the global hypothesis of this work is that decreased peroxisome proliferator activated receptor gamma coactivator (PGC)-1β underlies chronic binge alcohol (CBA)-mediated decreases in mitochondrial biogenesis and function in SKM of SIV+ female rhesus macaques and that PGC-1β is a potential therapeutic target to improve mitochondrial homeostasis. Data generated will provide a more comprehensive molecular understanding of mitochondrial dysfunction in the context of HIV and alcohol and will provide a foundation for future mechanistic and translational studies.

项目总结 本补编的目的是为完成NRSA个人奖学金提供更多的时间 题为《SIV/HIV中酒精诱导的骨骼肌失调：线粒体介导的机制》， F32AA027982在因新冠肺炎大流行而严重中断后。高危人群中的酒精使用情况 艾滋病毒携带者(PLWH)几乎是普通人群的两倍。长期高危饮酒与HIV/SIV 与包括骨骼肌(SKM)功能障碍在内的代谢合并症独立相关。基座 根据我们已发表的和初步的数据，这项工作的总体假设是过氧化酶体减少 增殖物激活受体γ共激活因子-1β在慢性酗酒中的作用 SIV+雌性恒河猴线粒体生物发生和功能降低及pGC-1β 是改善线粒体动态平衡的潜在治疗靶点。生成的数据将提供更多 在HIV和酒精和意志的背景下对线粒体功能障碍的全面分子理解 为未来的机械学和翻译研究奠定了基础。