Pennington/Louisiana NORC - Admin Supplement for Pilot and Feasibility studies 2021

彭宁顿/路易斯安那州 NORC - 2021 年试点和可行性研究行政补充

• 批准号: 10399166
• 负责人: Eric Ravussin
• 金额: $ 14.8万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10399166
• 关键词: Address; Adult; Advertising; Age; Animal Model; Applications Grants; Area; Award; Back; Basic Science; Binding; Centers of Research Excellence; Childhood; Chronic Disease; Clinical; Clinical Sciences; Collaborations; Data; Development; Direct Costs; Discipline; Disease; Environment; Equipment; Faculty; Feasibility Studies; Felis catus; Fostering; Funding; Future; Goals; Grant; Health; Health Sciences; Human; Human Resources; Impairment; Incentives; Infant; Infrastructure; Institution; Intervention; Life Cycle Stages; Life Style Modification; Longevity; Louisiana; Malignant Neoplasms; Medical; Mentors; Mentorship; Metabolic; Metabolic syndrome; Methods; Minority; Minority Groups; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Nutritional Science; Nutritional status; Obesity; Phenotype; Physical Function; Pilot Projects; Population; Population Sciences; Positioning Attribute; Postdoctoral Fellow; Prevention; Prevention strategy; Qi; Research; Research Personnel; Research Proposals; Resources; Role; Scientist; Seeds; Sister; Sleep Apnea Syndromes; Translational Research; Translations; Underrepresented Minority; Underrepresented Populations; Universities; Work; base; cardiovascular disorder risk; career; clinical investigation; cognitive function; cost; cost effective; critical period; design; feasibility research; innovation; medical schools; member; mother nutrition; multidisciplinary; next generation; non-alcoholic fatty liver disease; novel; nutrition; obesity treatment; operation; practical application; preservation; programs; recruit; synergism; therapy development; tool; training opportunity

PROJECT SUMMARY/ABSTRACT (OVERALL PENNINGTON/LOUISIANA NORC) This is an application for a 5-year competitive renewal of the Pennington/Louisiana Nutrition Obesity Research Center (NORC). The role of the NORC is to promote, facilitate and enhance collaborative and multi-disciplinary interactions to foster new research ideas and programs in nutrition and obesity. In doing so, the NORC facilitates and enhances the translation of basic nutritional research findings into the clinical arena and ultimately into practical applications. Since its inception in 2005, our research base funding has steadily grown to >$44 million per year in direct costs and 146 members including 63 Regular Members (part of the research base funding), 70 Collaborating Members (collaborate with our regular members) and 13 Mentored Members (Early Stage Investigators working under the mentorship of NORC members). The Center provides a stable administrative infrastructure and exemplary facilities. NORC members have access to three state-of-the-art biomedical cores to conduct their research with the highest rigorous standards; a “Human Phenotyping Core”, a “Molecular Mechanism Core” and an “Animal Model and Phenotyping Core”. Moreover, our vibrant and successful Pilot & Feasibility Grant Program provides Early Career Investigators with seed funding to jump-start innovative research programs and generate the necessary preliminary data for larger grant applications. Finally, our NORC Enrichment Program provides outstanding training opportunities and mentoring activities to junior scientists which extends to nutrition and obesity researchers across the entire state of Louisiana. The central theme of our NORC is “Nutrition, Obesity and Metabolic Health through the Lifespan”. To impact the prevention and treatment of obesity and its metabolic complications across the lifespan (from maternal nutrition to older age physical/cognitive functionality) through better nutrition, lifestyle modifications, and medical treatments, we have developed three translational research teams. These Translational Research Teams will address big research questions from the basic science level, to clinical investigation and finally implementation to the population. In each of these teams, research focuses on the mechanisms involved in health and disease, the development of treatment interventions and the implementation of preventive strategies. After 15 years of operation, the Pennington/Louisiana NORC with unwavering institutional support has never been as well- positioned to advance the science of nutrition and obesity on so many fronts and to foster the next generation of leaders in this field.

项目概要/摘要（整体彭宁顿/路易斯安那州诺克） 这是彭宁顿/路易斯安那营养肥胖研究 5 年竞争性更新的申请 中心（NORC）。 NORC 的作用是促进、促进和加强协作和多学科 互动，以促进营养和肥胖方面的新研究思路和计划。在此过程中，NORC 促进 并加强将基础营养研究成果转化为临床领域并最终转化为 实际应用。自 2005 年成立以来，我们的研究基地经费已稳步增长至超过 4400 万美元 每年直接费用和 146 名会员，其中包括 63 名正式会员（研究基础资金的一部分）， 70 名合作会员（与我们的正式会员合作）和 13 名指导会员（早期阶段） 调查人员在 NORC 成员的指导下工作）。中心提供稳定的行政管理 基础设施和示范设施。 NORC 成员可以使用三个最先进的生物医学核心 以最高严格的标准进行研究； “人类表型核心”、“分子 机制核心”和“动物模型和表型核心”。此外，我们充满活力和成功的 试点和可行性资助计划为早期职业研究人员提供种子资金以启动 创新研究计划，并为更大的资助申请生成必要的初步数据。最后， 我们的 NORC 强化计划为初级学生提供出色的培训机会和指导活动 科学家们的研究延伸到整个路易斯安那州的营养和肥胖研究人员。中央 我们的 NORC 的主题是“终生营养、肥胖和代谢健康”。为了影响 整个生命周期预防和治疗肥胖及其代谢并发症（来自孕产妇营养 通过更好的营养、生活方式的改变和医疗 治疗方面，我们建立了三个转化研究团队。这些转化研究团队将 解决从基础科学层面到临床研究和最终实施的重大研究问题 给民众。在每个团队中，研究重点是健康和疾病所涉及的机制， 制定治疗干预措施并实施预防策略。 15年后 在行动中，彭宁顿/路易斯安那州 NORC 得到了坚定不移的机构支持，从未如此出色- 致力于在许多方面推进营养和肥胖科学并培养下一代 该领域的领导者。