LAAZ-NPH Clinical Center
LAAZ-NPH 临床中心
基本信息
- 批准号:10539294
- 负责人:
- 金额:$ 170.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-10 至 2026-11-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAfrican AmericanAll of Us Research ProgramArea Under CurveArizonaBehaviorBehavioralBiologicalBiological MarkersBloodCardiometabolic DiseaseCatalogsChronic DiseaseClinical NutritionClinical ResearchCollaborationsCollectionComplexContinuous Glucose MonitorCross-Over StudiesDASH dietDataData SetDatabasesDietDietary AssessmentDietary InterventionDietary intakeDiseaseDomicilesEatingEffectivenessEligibility DeterminationEnrollmentEnvironmentFatty acid glycerol estersFecesFoodGeneticGlucoseGoalsHairHealthHealth PromotionHealth SciencesHeterogeneityHispanic AmericansHumanHybridsIndividualInpatientsInsulin ResistanceInvestigationLouisianaMeasuresMediterranean DietMetabolicMetabolic syndromeMetabolismMinorityModernizationMolecularNational Institute of Diabetes and Digestive and Kidney DiseasesNative AmericansObservational StudyOutpatientsParticipantPatient RecruitmentsPatternPhenotypePhotographyPhysical activityPhysiologyPlantsPlasmaPopulationPopulation HeterogeneityPositioning AttributePrecision HealthProteinsProtocols documentationRandomizedResearchResearch DesignResearch PersonnelSalivaSamplingSiteSpecific qualifier valueStandardizationTestingUrinecardiometabolismclinical centercognitive functiondesigndietarydoubly-labeled waterethnic diversityexperiencefeedinggut microbiotahealth disparityindividual responseinnovationinter-individual variationmachine learning algorithmmicrobiomenovelnutritionparticipant retentionprecision nutritionprediction algorithmprimary endpointprospectiverandomized trialrecruitresponseretention ratesecondary endpointstable isotopewearable devicewestern diet
项目摘要
PROJECT SUMMARY
Nutrition is at the epicenter of human health and disease. However, our current “one size fits all” approach to
clinical nutrition is failing a large segment of the population. Individual factors including genetics, metabolism,
physiology, microbiome, behavior, the built in and contextual environment all underlie the inherent variability in
response to diets. Exciting new research shows that machine learning algorithms can integrate this complex
information and predict how someone responds to a given diet. If validated, this innovative approach will
provide a radical change in the delivery of personalized nutrition prescriptions to promote health and treat
chronic diseases. The goal of the “Nutrition for Precision Health (NPH), powered by All of Us” consortium is to
generate a rich database from a diverse population to develop a first-of-its-kind diet prediction algorithm. The
aim of the Louisiana-Arizona Nutrition for Precision Health Center (LAAZ-NPH), consisting of LSU-Pennington
Biomedical (PBRC) in Baton Rouge, LSU-Health Sciences Center (LSUHSC) in New Orleans, and the NIDDK-
Phoenix Clinical Center (PIMC) in Phoenix, is to participate in the NPH consortium as a clinical center to
recruit, enroll and retain more than 2000 participants in the three planned study modules. In Module 1, 2,000
from the All of Us Research Program in Louisiana (Baton Rouge and New Orleans; 600 each) and Arizona
(Phoenix; 800) will be enrolled in a 10-day prospective, observational study. Following the completion of
Module 1, 300 study participants who meet specified eligibility criteria for enrollment to the controlled feeding
studies, will participate in Module 2 (PBRC, LSUHSC and PIMC; 100 each) and at least 100 in Module 3
(PBRC and PIMC only; ≥50 each). Module 2 is a controlled feeding study in an outpatient setting with 300
study participants while Module 3 is a controlled feeding study in an inpatient setting with at least 100 study
participants that completed Module 1. Modules 2 and 3 will use a block randomization cross-over study design
to evaluate the individual response to three, 14-day isocaloric diet interventions. The three intervention diets (a
combination of the Mediterranean and DASH diet (MEDASH); a sustainable predominantly plant-based
Flexitarian diet (FLEX) and a Highly Preferred Western Diet (HPWD) will be separated by a 7-21 day wash out
periods. Our primary endpoint is the post-prandial plasma glucose response (PPGR) to a standardized mixed
meal tolerance test (MMTT) as measured by the incremental glucose area under the curve over 180 min
(AUC180). Secondary endpoints are biomarkers of cardiometabolic health including insulin resistance and a
metabolic syndrome score. The rich set of data and biospecimens collected by our proposed center will be
used to inform paradigm shifting approaches that enable large-scale delivery of personalized dietary
prescriptions to promote general health, delay cardiometabolic diseases, and importantly address health
disparities.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eric Ravussin其他文献
Eric Ravussin的其他文献
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{{ truncateString('Eric Ravussin', 18)}}的其他基金
Pennington/Louisiana NORC - Admin Supplement for Pilot and Feasibility studies 2021
彭宁顿/路易斯安那州 NORC - 2021 年试点和可行性研究行政补充
- 批准号:
10399166 - 财政年份:2021
- 资助金额:
$ 170.95万 - 项目类别:
Pennington/Louisiana NORC - Supplement NOT-OD-21-089
彭宁顿/路易斯安那州 NORC - 补充 NOT-OD-21-089
- 批准号:
10408519 - 财政年份:2021
- 资助金额:
$ 170.95万 - 项目类别:
Role of slowly digestible starch in diabetes risk factors in pre-diabetic people
缓慢消化淀粉在糖尿病前期人群糖尿病危险因素中的作用
- 批准号:
8372789 - 财政年份:2012
- 资助金额:
$ 170.95万 - 项目类别:
Role of slowly digestible starch in diabetes risk factors in pre-diabetic people
缓慢消化淀粉在糖尿病前期人群糖尿病危险因素中的作用
- 批准号:
8501442 - 财政年份:2012
- 资助金额:
$ 170.95万 - 项目类别:
Role of Slowly Digestible Starch in Diabetes Risk Factors in Pre-Diabetic People
缓慢消化淀粉在糖尿病前期人群糖尿病危险因素中的作用
- 批准号:
9060311 - 财政年份:2012
- 资助金额:
$ 170.95万 - 项目类别:
Role of slowly digestible starch in diabetes risk factors in pre-diabetic people
缓慢消化淀粉在糖尿病前期人群糖尿病危险因素中的作用
- 批准号:
8668050 - 财政年份:2012
- 资助金额:
$ 170.95万 - 项目类别:
Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women
肥胖女性皮下脂肪分布的细胞动力学
- 批准号:
8666638 - 财政年份:2011
- 资助金额:
$ 170.95万 - 项目类别:
Cellular Dynamics of Subcutaneous Fat Distribution in Obese Women
肥胖女性皮下脂肪分布的细胞动力学
- 批准号:
8440368 - 财政年份:2011
- 资助金额:
$ 170.95万 - 项目类别:
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