NORC admin supplement

项目总结/摘要（总体彭宁顿/Louisiana NORC） 这是彭宁顿/路易斯安那州营养肥胖研究的5年竞争性更新申请 中心（NORC）。NORC的作用是促进，促进和加强合作和多学科 互动，以促进新的研究思路和计划在营养和肥胖。在此过程中，NORC促进 并促进基础营养研究成果向临床竞技场的转化， 实际应用等自2005年成立以来，我们的研究基础资金稳步增长到> 4400万美元 每年的直接费用和146名成员，包括63名普通成员（研究基地资金的一部分）， 70名合作成员（与我们的普通成员合作）和13名指导成员（早期阶段） 在NORC成员指导下工作的调查人员）。该中心提供了一个稳定的行政 基础设施和示范设施。NORC成员可以使用三个最先进的生物医学核心 以最严格的标准进行研究;一个“人类表型核心”，一个“分子生物学”， 机制核心”和“动物模型和表型核心”。此外，我们充满活力和成功的 试点和可行性补助金计划为早期职业调查员提供种子资金，以启动 创新的研究计划，并为更大的赠款申请产生必要的初步数据。最后， 我们的NORC强化计划为初级学生提供出色的培训机会和指导活动， 科学家，这延伸到整个路易斯安那州的营养和肥胖研究人员。中央 我们NORC的主题是“终生营养、肥胖和代谢健康”。冲击 预防和治疗肥胖症及其在整个生命周期中的代谢并发症（从母体营养 通过更好的营养、生活方式的改变和医疗保健， 在治疗方面，我们已经建立了三个转化研究团队。这些翻译研究团队将 解决从基础科学水平到临床研究和最终实施的重大研究问题 对大众来说。在每一个团队中，研究的重点是健康和疾病的机制， 制定治疗干预措施和实施预防战略。经过15年的 操作，彭宁顿/路易斯安那州NORC与坚定不移的机构支持从来没有像- 定位于推进营养和肥胖科学在这么多方面，并培养下一代的 这个领域的领导者。

PROJECT SUMMARY/ABSTRACT (OVERALL PENNINGTON/LOUISIANA NORC) This is an application for a 5-year competitive renewal of the Pennington/Louisiana Nutrition Obesity Research Center (NORC). The role of the NORC is to promote, facilitate and enhance collaborative and multi-disciplinary interactions to foster new research ideas and programs in nutrition and obesity. In doing so, the NORC facilitates and enhances the translation of basic nutritional research findings into the clinical arena and ultimately into practical applications. Since its inception in 2005, our research base funding has steadily grown to >$44 million per year in direct costs and 146 members including 63 Regular Members (part of the research base funding), 70 Collaborating Members (collaborate with our regular members) and 13 Mentored Members (Early Stage Investigators working under the mentorship of NORC members). The Center provides a stable administrative infrastructure and exemplary facilities. NORC members have access to three state-of-the-art biomedical cores to conduct their research with the highest rigorous standards; a “Human Phenotyping Core”, a “Molecular Mechanism Core” and an “Animal Model and Phenotyping Core”. Moreover, our vibrant and successful Pilot & Feasibility Grant Program provides Early Career Investigators with seed funding to jump-start innovative research programs and generate the necessary preliminary data for larger grant applications. Finally, our NORC Enrichment Program provides outstanding training opportunities and mentoring activities to junior scientists which extends to nutrition and obesity researchers across the entire state of Louisiana. The central theme of our NORC is “Nutrition, Obesity and Metabolic Health through the Lifespan”. To impact the prevention and treatment of obesity and its metabolic complications across the lifespan (from maternal nutrition to older age physical/cognitive functionality) through better nutrition, lifestyle modifications, and medical treatments, we have developed three translational research teams. These Translational Research Teams will address big research questions from the basic science level, to clinical investigation and finally implementation to the population. In each of these teams, research focuses on the mechanisms involved in health and disease, the development of treatment interventions and the implementation of preventive strategies. After 15 years of operation, the Pennington/Louisiana NORC with unwavering institutional support has never been as well- positioned to advance the science of nutrition and obesity on so many fronts and to foster the next generation of leaders in this field.