NORC admin supplement

项目摘要/摘要(彭宁顿/路易斯安那州NORC总体情况) 这是一份申请Pennington/Louisiana营养性肥胖研究的5年竞争性续订的申请表 中心(NORC)。NORC的作用是促进、促进和加强协作和多学科 促进营养与肥胖领域新的研究思路和项目的互动。通过这样做，NORC促进了 并加强将基本营养研究成果转化为临床领域，并最终转化为 实际应用。自2005年成立以来，我们的研究基地资金已稳步增长至4400万美元 每年直接费用和146名成员，包括63名正式成员(研究基础资金的一部分)， 70名合作成员(与我们的正式成员合作)和13名指导成员(早期 调查人员在NORC成员的指导下工作)。该中心提供稳定的行政管理 基础设施和示范设施。NORC成员可以接触到三个最先进的生物医学核心 以最高的标准进行他们的研究；“人类表型核心”，“分子” “机制核心”和“动物模型和表型核心”。此外，我们充满活力和成功的 试点和可行性补助计划为早期职业研究人员提供启动种子资金 创新的研究计划，并为更大规模的赠款申请生成必要的初步数据。最后， 我们的NORC丰富计划为青少年提供出色的培训机会和指导活动 科学家包括路易斯安那州全州的营养和肥胖研究人员。中环 我们NORC的主题是“营养、肥胖和终生代谢健康”。要影响 预防和治疗肥胖症及其终生代谢并发症(来自产妇营养 到老年人的身体/认知功能)通过更好的营养、生活方式改变和医疗 在治疗方面，我们建立了三个翻译研究团队。这些翻译研究团队将 解决从基础科学层面到临床研究和最终实施的重大研究问题 对所有人来说。在每个团队中，研究的重点都是与健康和疾病有关的机制， 制定治疗干预措施和实施预防战略。在经历了15年的 行动以来，拥有坚定不移的机构支持的彭宁顿/路易斯安那州NORC从未像现在这样- 定位于在如此多的战线上推进营养与肥胖的科学，并培养下一代 这一领域的领导者。

PROJECT SUMMARY/ABSTRACT (OVERALL PENNINGTON/LOUISIANA NORC) This is an application for a 5-year competitive renewal of the Pennington/Louisiana Nutrition Obesity Research Center (NORC). The role of the NORC is to promote, facilitate and enhance collaborative and multi-disciplinary interactions to foster new research ideas and programs in nutrition and obesity. In doing so, the NORC facilitates and enhances the translation of basic nutritional research findings into the clinical arena and ultimately into practical applications. Since its inception in 2005, our research base funding has steadily grown to >$44 million per year in direct costs and 146 members including 63 Regular Members (part of the research base funding), 70 Collaborating Members (collaborate with our regular members) and 13 Mentored Members (Early Stage Investigators working under the mentorship of NORC members). The Center provides a stable administrative infrastructure and exemplary facilities. NORC members have access to three state-of-the-art biomedical cores to conduct their research with the highest rigorous standards; a “Human Phenotyping Core”, a “Molecular Mechanism Core” and an “Animal Model and Phenotyping Core”. Moreover, our vibrant and successful Pilot & Feasibility Grant Program provides Early Career Investigators with seed funding to jump-start innovative research programs and generate the necessary preliminary data for larger grant applications. Finally, our NORC Enrichment Program provides outstanding training opportunities and mentoring activities to junior scientists which extends to nutrition and obesity researchers across the entire state of Louisiana. The central theme of our NORC is “Nutrition, Obesity and Metabolic Health through the Lifespan”. To impact the prevention and treatment of obesity and its metabolic complications across the lifespan (from maternal nutrition to older age physical/cognitive functionality) through better nutrition, lifestyle modifications, and medical treatments, we have developed three translational research teams. These Translational Research Teams will address big research questions from the basic science level, to clinical investigation and finally implementation to the population. In each of these teams, research focuses on the mechanisms involved in health and disease, the development of treatment interventions and the implementation of preventive strategies. After 15 years of operation, the Pennington/Louisiana NORC with unwavering institutional support has never been as well- positioned to advance the science of nutrition and obesity on so many fronts and to foster the next generation of leaders in this field.