COBRE-DIABETES

项目总结/摘要 此申请是为了补充支持生物医学研究卓越（COBRE）的第一阶段中心 在夏威夷大学（UH）的糖尿病（1 P20 GM 113134 -04），以响应资助机会， GM-21-029，“NIGMS资助的中心和核心设备采购行政补充 设施”。COBRE-Diabetes开发了一个资源核心，致力于支持职业发展 为年轻的研究人员和促进糖尿病相关的研究在国家，这是迫切需要的。是 据估计，到2050年，该州三分之一的人口将患有糖尿病。 COBRE-Diabetes Resource Core的目标是建立一个新的、易于使用的现代化基础设施， 支持对糖尿病的机制、诊断、预防和/或治疗的研究，以解决 夏威夷少数民族人口的健康差异。我们唯一的目标是保持增长， 增强资源核心的可持续性。有了这个建议，我们将优化我们的核心能力， 继续在COBRE-Diabetes第一阶段成功启动的能力提高 经费为了实现这一目标，我们请求提供资金，用于购置两个新的 设备.我们希望用一个新的系统来取代现有的过时的Xenogen Vivo Vision IVIS Lumina成像系统。 IVIS Lumina XRMS体内成像系统。该设备提供尖端的体内荧光， 生物发光技术结合低剂量2D X射线，允许非侵入性和精确的代谢 分析。这将使我们能够扩大多只动物进行纵向研究的能力。的 第二台设备是i-STAT临床血液分析仪，采用先进的单点检测技术， 使用i-STAT测试卡，在单一平台上提供广泛的测试，包括快速测试， 电解质、化学物质、血气、红细胞压积和血红蛋白或代谢状态的快速评估 和肾功能。该系统使用最少的血液体积，不需要处死动物（小鼠）。 血液分析目前使用个人和专用试剂盒进行，这是费力的或承包服务 在大学外面。刚果民主共和国正在进行的许多项目最好在夏威夷进行。 我们与美国本土的距离要求我们开发核心服务的基本功能， 糖尿病研究与COBRE资源。医学院院长承诺提供 机构支助，以支付购买这些设备后三年的运作费用。

PROJECT SUMMARY/ABSTRACT This application is for a supplement to support a Phase I Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) on Diabetes (1P20GM113134-04) in response to funding opportunity NOT- GM-21-029, “Administrative Supplements for Equipment Purchases for NIGMS-funded Center and Core Facilities”. The COBRE-Diabetes has developed a Resource Core dedicated to supporting career development for young investigators and to foster diabetes-related research in the state, which is acutely needed. It is estimated that a third of the State’s population will be living with diabetes by the year 2050. The COBRE-Diabetes Resource Core goal is to establish a new and easily accessible modern infrastructure to support investigations in the mechanisms, diagnosis, prevention, and/or treatment of diabetes to address health disparities in the minority populations in Hawaii. Our unique aim is to Maintain the growth and enhance the sustainability of Resource Core. With this proposal, we will optimize our core capacity in order to continue capacity improvement that has been successfully initiated in the first Phase of COBRE-Diabetes funding. In order to accomplish this objective, we request funding for the acquisition of two new pieces of equipment. We hope to replace an existing obsolete Xenogen Vivo Vision IVIS Lumina Imaging system with an IVIS Lumina XRMS in vivo imaging system. This is equipment offers cutting edge in vivo fluorescence and bioluminescence technology combined with low dose 2D X-ray allowing for non-invasive and precise metabolic analyses. This will give us an expanded capacity with multiple animals to perform longitudinal studies. The second equipment is an i-STAT clinical blood analyzer that operates with the advanced technology of single- use i-STAT test cartridges offering a wide array of tests on a single platform, including rapid tests for electrolytes, chemistries, blood gases, hematocrit and hemoglobin or the fast evaluation of metabolic status and renal function. This system uses minimal blood volumes, which will not require animal (mouse) sacrifice. Blood analyses are currently done using individual and dedicated kits that is laborious or contracting services outside of the University. There are many projects ongoing in the DRC that can best be performed in Hawaii. Our distance from US mainland requires that we develop a fundamental repertoire of Core services for diabetes research with COBRE resources. The Dean of the Medical School has committed to provide institutional support to cover the cost of operation for three years after the purchase of these equipment.