Cognitive and Neurobiological Approaches to Plasticity (C-NAP) Center

项目摘要 第一阶段COBRE导致建立了一个独特的认知和 可塑性的神经生物学方法（CNAP）。研究项目和试点赠款检查认知/神经 在整个生命周期的可塑性，利用人类和动物的基本和翻译/应用方法 模型最终目标是确定认知和神经可塑性的机制， 改善功能。三个研究核心设施支持研究项目，试点赠款和计划： 行为神经科学核心（BN）、脑电图（EEG）核心和神经信息学核心 (NI)提供堪萨斯州内独特的研究基础设施资源。BN核心经历了 2017年进行了重大翻修（总成本近100万美元），其中包括设施和设备升级， 用户手术和湿实验室。还安装了一个新的笼子清洗设施，以支持增加的动物 住房能力。升级增强了这个核心的能力，以支持尖端的动物神经科学 research.这一核心支助了两个项目和一个试点赠款， 以及一个将在下一个赠款年度使用这一核心的试点赠款。目前的补充将加强这一点 通过购买一个新的低温恒温器作为升级，并最终取代目前过时的 单位使用该核心的所有五个实验室都严重依赖低温恒温器，并且没有足够的备份 因此，这次升级将确保研究的连续性。EEG核心建立于 2018年作为一个新的多用户核心，以支持人类认知神经科学研究。这一核心支持了 两个试点赠款和一个项目，该中心预计将支持一个试点项目和一个主要项目， 即将到来的拨款年度将使用这个核心。此补充将支持对当前 放大器已经过时了。为了扩展该核心的功能，CNAP将购买一个重复的 跨磁刺激系统，以支持神经调节研究。这是一个重大的 核心将能够支持的研究技术的进步。国家情报中心成立于 2017年作为新的核心，与Beocat高性能计算设施捆绑在一起。此核心支持所有项目 和试点赠款，并直接与EEG核心和CNAP科学交换中的其他两个核心接口 网络（堪萨斯大学医学中心的霍格伦德脑成像中心和小动物研究中心） 核磁共振成像/核磁共振成像核心化学在K状态）。此补充将升级文件系统，以支持 数据密集型神经成像分析和建模活动， 目前通用系统。这一升级将为支持尖端分析创造机会 所有国家农业政策中心资助的项目和试点赠款的技术。总的来说，此补充中的升级提供了 多方面的机会，以支持CNAP的成功和发展，以确保中心供应高 优质的设备和尖端的技术，以促进CNAP初级调查员的成功。

PROJECT SUMMARY This Phase 1 COBRE resulted in the establishment of a unique, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (CNAP). Research projects and pilot grants examine cognitive/neural plasticity across the lifespan, utilizing basic and translational/applied approaches in humans and animal models. The ultimate goal is to determine the mechanisms involved in cognitive and neural plasticity to improve functioning. Three research core facilities support the research projects, pilot grants, and programs: a Behavioral Neuroscience Core (BN), an Electroencephalography (EEG) Core, and a Neuroinformatics Core (NI), supplying unique research infrastructure resources within the State of Kansas. The BN core underwent major renovations in 2017 (nearly $1M in total costs) which included facility and equipment upgrades to shared user surgical and wet laboratories. A new cage wash facility was also installed to support increased animal housing capacity. The upgrades enhanced the ability of this core to support cutting-edge animal neuroscience research. This core has supported two projects and one pilot grant and CNAP anticipates funding one project and one pilot grant that will use this core in the coming grant year. The current supplement will enhance this core through the purchase of a new cryostat as an upgrade and eventual replacement for the current outdated unit. All five laboratories that use this core rely heavily on the cryostat and there are insufficient back-up resources on campus, so this upgrade will ensure continuity of research. The EEG core was established in 2018 as a new multi-user core to support human cognitive neuroscience research. This core has supported two pilot grants and a project, and the center anticipates supporting one pilot project and a primary project in the coming grant year that will use this core. This supplement will support a critical upgrade to the current amplifier which is becoming outdated. To expand the functionality of this core, CNAP will purchase a repetitive transmagnetic stimulation system to support neuromodulation research. This represents a significant advancement in the research techniques that the core will be able to support. The NI core was established in 2017 as a new core, tied in with the Beocat high-performance computing facility. This core supports all project and pilot grants and directly interfaces with the EEG core and two other cores in the CNAP scientific exchange network (the Hoglund Brain Imaging Center at the University of Kansas Medical Center and the Small Animal Imaging NMR/MRI Core in Chemistry at K-State). This supplement will upgrade the file system for supporting data-intensive neuroimaging analysis and modeling activities to increase performance by 10,000x over the current general-purpose system. This upgrade will create opportunities to support cutting-edge analysis techniques for all CNAP funded projects and pilot grants. Overall, the upgrades in this supplement provide multi-faceted opportunities to support the success and growth of CNAP to ensure the center supplies high quality equipment and cutting-edge technologies to promote the success of CNAP junior investigators.