Cognitive and Neurobiological Approaches to Plasticity (C-NAP) Center

总体项目摘要 这个COBRE应用程序将形成一个独特的，主题研究中心的认知和神经生物学 可塑性方法（C-NAP）。四个主要的研究项目桥梁在认知卓越领域 堪萨斯州立大学（KSU）的行为神经科学项目和 威奇托州立大学（WSU）。这些项目检查了整个生命周期的认知/神经可塑性， 人类和动物模型的基本和转化/应用方法。最终目标是确定 参与认知和神经可塑性的机制，以改善功能。这一目标高度 与NIH的核心使命“寻求有关生命系统的性质和行为的基本知识”相关 并将这些知识应用于增进健康、延长寿命、减少疾病和残疾。”三 研究核心设施将支持研究项目和计划，行为神经科学核心 (KSU)，神经信息学核心（KSU）和驾驶模拟器核心（WSU），提供独特的研究 堪萨斯州的基础设施资源。C-NAP的成功和发展将通过以下方式实现： (1)一个教师指导计划，将提供高质量的研究指导，由国家认可的 研究人员指导团队将支持研究计划和赠款申请开发的各个方面 促进每个项目负责人成功获得R 01级资金;（2）新教师招聘 在KSU和WSU，以确保C-NAP的增长和寿命以及核心设施的活跃使用;（3）试点 通过资助该地区大学的项目来刺激中心发展的赠款计划;（4） 博士培训计划，将提供多学科培训沿着跨学科的主题，桥梁 核心设施和项目，以及创造独立的途径;（5）科学交流网络 (SEN)这将提供培训机会和利用更多核心设施的机会， COBRE核心项目、试点项目、博士后和研究生项目的研究生产率和成功率 学生学员和相关的C-NAP教师。最初的合作伙伴包括Hoglund脑成像和K-INBRE 中心在堪萨斯大学医学院，COBRE中心在北达科他州州立大学和 内华达大学里诺分校，KSU的小动物成像核心，以及 威奇托。SEN将发展并扩展到附近的其他大学和研究中心（例如，大学 堪萨斯-劳伦斯大学、密苏里-堪萨斯城大学、密苏里-哥伦比亚大学、内布拉斯加大学- 林肯，俄克拉荷马州大学，和创伤性脑损伤单位在英尺。Riley）提供丰富的机会 促进研究项目的发展。C-NAP中心将在第3年和第5年举办小型会议 这将包括来自C-NAP项目，计划和SEN成员的参与者，以展示和分享研究 与网络外的调查人员合作，提高C-NAP的全国声誉。

OVERALL PROJECT SUMMARY This COBRE application will form a unique, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (C-NAP). Four primary research projects bridge areas of excellence in the Cognitive and Behavioral Neuroscience programs at Kansas State University (KSU) and the Human Factors program at Wichita State University (WSU). The projects examine cognitive/neural plasticity across the lifespan, utilizing basic and translational/applied approaches in humans and animal models. The ultimate goal is to determine the mechanisms involved in cognitive and neural plasticity to improve functioning. This goal is highly relevant to the NIH core mission “to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.” Three research core facilities will support the research projects and programs, a Behavioral Neuroscience Core (KSU), a Neuroinformatics Core (KSU), and a Driving Simulator Core (WSU), supplying unique research infrastructure resources within the State of Kansas. The success and growth of C-NAP will be enabled through: (1) a faculty mentoring program that will provide high-quality research mentoring by nationally-recognized researchers. The mentoring team will support all aspects of research program and grant application development to promote success in securing R01-level funding by each of the project leaders; (2) new faculty recruitment at KSU and WSU to ensure growth and longevity of C-NAP and vibrant usage of the core facilities; (3) a pilot grant program that will stimulate center growth by funding projects at universities in the region; (4) a post- doctoral training program that will provide multi-disciplinary training along cross-cutting themes that bridge core facilities and projects, coupled with creating pathways to independence; (5) a scientific exchange network (SEN) that will provide training opportunities and access to additional core facilities with the goal of promoting the research productivity and success of the COBRE core projects, pilot projects, post-doctoral and graduate student trainees, and associated C-NAP faculty. Initial partners include the Hoglund Brain Imaging and K-INBRE centers at the University of Kansas Medical School, COBRE centers at North Dakota State University and the University of Nevada-Reno, the small-animal imaging core at KSU, and the Envision Research Institute in Wichita. The SEN will grow and expand to other nearby universities and research centers (e.g., University of Kansas-Lawrence, University of Missouri-Kansas City, University of Missouri-Columbia, University of Nebraska- Lincoln, the University of Oklahoma, and the Traumatic Brain Injury Unit at Ft. Riley) providing rich opportunities for promoting the growth of research programs. The C-NAP center will host mini-conferences in Years 3 and 5 that will include participants from C-NAP projects, programs, and SEN members to showcase and share research with investigators from outside of the network, promoting the national reputation of C-NAP.