SC INBRE Collaborative Administrative Supplement - Epigenetic and mRNA translational control mediated by adherens protein PLEKHA7

SC INBRE 协作管理补充文件 - 由粘附蛋白 PLEKHA7 介导的表观遗传和 mRNA 翻译控制

• 批准号: 10399796
• 负责人: EDIE C GOLDSMITH
• 金额: $ 12.62万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10399796
• 关键词: Address; Administrative Supplement; Americas; Area; Award; Big Data; Biochemistry; Bioinformatics; Biomedical Engineering; Biomedical Research; Cells; Collaborations; Country; Development; Economically Deprived Population; Educational workshop; Enrollment; Ensure; Epigenetic Process; Extramural Activities; Faculty; Female; Fostering; Funding; Funding Opportunities; Future; Geographic Distribution; Geography; Goals; Growth; Health; Health Personnel; Health Professional; Healthcare; High School Faculty; Historically Black Colleges and Universities; Industry; Institution; Lead; Mediating; Medical; Mentors; Messenger RNA; Military Personnel; Modeling; Molecular Biology; Neurosciences; Occupations; Paper; Phase; Physicians; Pilot Projects; Population; Presbyterian Church; Proteins; Publications; Publishing; Regenerative Medicine; Research; Research Infrastructure; Research Project Grants; Research Training; Schools; Scientist; Solid; Source; South Carolina; Students; Teacher Professional Development; Time; Training; Translating; Underrepresented Minority; Universities; Woman; Work; bioinformatics tool; biomedical scientist; career; college; demographics; disadvantaged student; experience; faculty support; human disease; inter-institutional; interest; male; member; minority student; next generation; outreach; outreach program; personalized medicine; programs; role model; student training; success; training opportunity; undergraduate education; undergraduate research; undergraduate research experience; undergraduate student; underrepresented minority student; underserved area; university student

Project Summary The South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) is a state-wide network comprised of three Comprehensive Research Universities (CRUs) and ten Primarily Undergraduate Institutions (PUIs) whose goals are to enhance the biomedical research infrastructure and promote undergraduate research training in South Carolina while increasing access to research opportunities and careers in biomedicine for underrepresented minorities and economically disadvantaged students. The scientific themes in SC INBRE emerge from the research expertise in South Carolina and include Biochemistry and Cell/Molecular Biology, Bioengineering, Biomedical Engineering, Regenerative Medicine, and Neuroscience. With the rise of “big data” and a move towards personalized medicine, the need for research and training in Bioinformatics has increased. To meet this demand, the Bioinformatics Core of SC INBRE provides workshops and hands-on training opportunities for faculty and students seeking to apply bioinformatics tools to their research. During the current funding cycle, SC INBRE made significant progress in addressing these goals. From 2015-2019, 415 students were trained in biomedical research labs in the SC INBRE network. Of these students, 39% were male, 61% female and overall 29% were underrepresented minorities. For the students who completed their undergraduate education during this funding period, 44% enrolled in graduate school, 17% went to medical/health professional school, and 39% obtained a job industry. SC INBRE faculty and students produced over 100 publications and gave over 600 presentations during this funding cycle. Their work led to over $9 million dollars in extramural funding from a variety of federal and non-federal sources. Fostering inter-institutional collaborations and promoting a research culture at PUIs, SC INBRE contributed to a collaborative U54 award which brings $12.5 million in research dollars to South Carolina. During the next phase of SC INBRE, the network’s reach across the state will be expanded to include several new PUIs, with long-time network members serving a role models for these new institutions. The Developmental Research Project and Bioinformatics Pilot Project programs will continue to support faculty-driven research and student training. SC INBRE will continue to promote undergraduate research training at network PUIs through SC INRBE-sponsored Undergraduate Research Programs and proposes to expand training capacity at five PUIs through renovation of existing space/facilities. Career and professional development activities will be provided to SC INBRE faculty and students, as well as opportunities to network and develop collaborations with SC INBRE colleagues. Outreach programs developed at selected SC INBRE institutions will engage high school teachers and students, strengthening the pipeline of future college students interested in biomedical research careers and actively encouraging participation by underrepresented minority students and those from underserved areas in South Carolina.

项目摘要 南卡罗来纳州IDEA卓越生物医学研究网络(SC INBRE)是一个覆盖全州的网络 由三所综合性研究型大学(CRU)和十所以本科为主的机构组成 (PUI)，其目标是加强生物医学研究基础设施并促进本科生 在南卡罗来纳州进行研究培训，同时增加获得研究机会和职业的机会 为代表不足的少数族裔和经济困难学生提供生物医学。科学主题 在南卡罗来纳州，INBRE从研究专长中脱颖而出，包括生物化学和 细胞/分子生物学、生物工程、生物医学工程、再生医学和神经科学。 随着“大数据”的兴起和向个性化医疗的迈进，研究和培训在 生物信息学有所增长。为了满足这一需求，SC INBRE的生物信息学核心提供了研讨会 以及为寻求将生物信息学工具应用于其 研究。在本供资周期内，科学和技术研究所在实现这些目标方面取得了重大进展。 2015-2019年，在SC INBRE网络的生物医学研究实验室培训了415名学生。其中 学生中，39%是男性，61%是女性，总体上29%是代表不足的少数族裔。对于学生来说 在这一资助期间完成本科教育的学生中，44%进入了研究生院， 17%的人上了医疗/健康专业学校，39%的人在行业找到了工作。理工学院教职员工和 在这个资助周期中，学生们出版了100多份出版物，并发表了600多次演讲。他们的工作 从各种联邦和非联邦来源获得了900多万美元的外部资金。养育 机构间合作和促进研究所的研究文化，SC INBRE促进了 合作U54奖，为南卡罗来纳州带来1250万美元的研究资金。在下一次 SC INBRE阶段，整个州的网络覆盖范围将扩大到包括几个新的PUI， 长期为这些新机构服务的网络成员的榜样。发展性研究 项目和生物信息学试点项目将继续支持教师主导的研究和学生 训练。SC INBRE将继续通过SC促进网络PUI的本科生研究培训 INRBE赞助的本科生研究计划，并建议扩大5个PUI的培训能力 通过翻新现有的空间/设施。将提供职业发展和职业发展活动 给SC INBRE的教职员工和学生，以及与SC建立网络和发展合作的机会 INBRE的同事们。在选定的SC INBRE机构开发的外展计划将吸引高中 教师和学生，加强未来大学生对生物医学研究感兴趣的渠道 职业，并积极鼓励代表不足的少数族裔学生和来自 南卡罗来纳州服务不足的地区。