WV INBRE: Inhibition of DNA Methyltransferase Suppresses CD138 Plasma Cells of Multiple Myeloma and Reverts Bone Marrow Stromal Cell-induced Drug Resistance

WV INBRE：抑制 DNA 甲基转移酶可抑制多发性骨髓瘤的 CD138 浆细胞并恢复骨髓基质细胞诱导的耐药性

• 批准号: 10400305
• 负责人: GARY O RANKIN
• 金额: $ 15.08万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400305
• 关键词: Academy; Award; Bioinformatics; Biomedical Research; Bone Marrow; Cancer Biology; Cardiovascular Diseases; Centers of Research Excellence; Chronic Disease; Core Facility; DNA methyltransferase inhibition; Development; Diabetes Mellitus; Doctor of Philosophy; Drug resistance; Educational workshop; Evaluation; Faculty; Funding; Funding Opportunities; Genomics; Grant; Health; Health Sciences; Health Technology; Human; Infrastructure; Institution; Interdisciplinary Study; Knowledge; Lead; Leadership; Malignant Neoplasms; Mentors; Minority Recruitment; Minority-Serving Institution; Molecular and Cellular Biology; Multiple Myeloma; National Center for Research Resources; Natural Products; Nature; Network Infrastructure; Obesity; Phase; Pilot Projects; Plasma Cells; Postdoctoral Fellow; Principal Investigator; Program Research Project Grants; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Stromal Cells; Structure; Students; Technology; Training; United States National Institutes of Health; Universities; West Virginia; addiction; base; career; career development; cohesion; experience; faculty research; graduate student; health science research; high school; multidisciplinary; programs; research and development; science teacher; skills; student participation; success; summer research; undergraduate research experience; undergraduate student

West Virginia is a State that has had a historically low success rate in obtaining grant funds from the National Institutes of Health and has been designated as an IDeA state. In this renewal application, Marshall University (MU), in partnership with West Virginia University (WVU), will continue to build on the success of the West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) to help develop biomedical research infrastructure and capacity throughout the network and provide biomedical research experiences for undergraduate and graduate students from the partner institutions. MU, in partnership with WVU, will continue to serve as lead institutions to a research network consisting of fourteen primarily undergraduate institutions (PUIs)/partner institutions. The multi-disciplinary theme for WV-INBRE will be cellular and molecular biology with an emphasis on chronic disease (cancer, cardiovascular disease, diabetes, obesity-related illness and addiction). Supporting the activities of the network will be the Administrative, Bioinformatics and Genomics Cores which have been established to facilitate research progress, mentoring and training, and career development of investigators and students at the lead and partner institutions. Research in the network will be supported by major PUI research awards, Faculty Research Development Awards (FRDAs), and Center for Natural Products Research, Cancer Biology Research and Chronic Disease Research Program pilot project awards. Ties to WV COBREs, the Health Sciences and Technology Academy (HSTA; an NIH-funded SEPA program) and the WV IDeA-CTR (WVCTSI) will be expanded.. Proposed programs will provide research opportunities for PUI students, including the summer research program, HSTA Scholar initiative, and the Developmental Research Project Program to help serve as a pipeline for these students into health-related research careers. HSTA high school science teachers and partner institution faculty fellows will also be provided summer research opportunities at the lead and network institutions. Through providing workshops, seminars, research training and mentoring, and access to state-of-the-art core facilities, WV- INBRE will help enhance the science and technology knowledge and skill base of the WV workforce.

西弗吉尼亚州是一个在获得赠款资金方面成功率历史最低的州， 美国国立卫生研究院，并已被指定为一个IDEA国家。在这次更新中， 申请，马歇尔大学（MU），与西弗吉尼亚大学（WVU）合作，将 继续在西弗吉尼亚州IDEA生物医学研究网络的成功基础上再接再厉 卓越（WV-INBRE），以帮助发展生物医学研究基础设施和能力 在整个网络，并提供生物医学研究经验的本科生和 来自合作机构的研究生。与WVU合作，MU将继续 作为由十四名主要本科生组成的研究网络的牵头机构 机构（PUI）/伙伴机构。WV-INBRE的多学科主题将是细胞 和分子生物学，重点是慢性疾病（癌症，心血管疾病， 糖尿病、肥胖相关疾病和成瘾）。支持该网络活动的将有： 行政、生物信息学和基因组学核心， 促进研究进展、指导和培训以及研究人员的职业发展 以及牵头和合作机构的学生。该网络的研究将得到以下方面的支持： 主要PUI研究奖，教师研究发展奖（FRDAs），和中心 天然产物研究、癌症生物学研究和慢性病研究计划 试点项目奖。与WV COBREs，健康科学和技术学院的联系 (HSTA NIH资助的SEPA项目）和WV IDEA-CTR（WVCTSI）将得到扩展。 拟议的计划将为PUI学生提供研究机会，包括夏季 研究计划，HSTA学者倡议，和发展研究项目计划 以帮助这些学生成为健康相关研究职业的管道。HSTA高 学校的科学教师和合作机构的教师研究员也将提供夏季 在牵头机构和网络机构的研究机会。通过举办讲习班， 研讨会，研究培训和指导，并获得最先进的核心设施，西弗吉尼亚州- INBRE将帮助加强西弗吉尼亚州的科学和技术知识和技能基础 劳动力