Cocaine use, viral suppression and precursors of stroke in HIV infection

HIV 感染中的可卡因使用、病毒抑制和中风前兆

• 批准号: 10401450
• 负责人: ELISE D. RILEY
• 金额: $ 80.52万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10401450
• 关键词: AIDS/HIV problem; Acute; Address; Age; Alcohol consumption; Alcohols; Amphetamines; Biological Markers; C-reactive protein; CD4 Lymphocyte Count; Cannabis; Cardiovascular Diseases; Chronic; Clinic; Clinical; Cocaine; Cocaine use disorder; Communities; Data; Detection; Diagnosis; Drug abuse; Drug usage; Failure; Functional disorder; Goals; HIV; HIV Infections; Homelessness; Individual; Infarction; Inflammation; Inflammatory; Levamisole; Lidocaine; Link; Low Income Population; Low income; Magnetic Resonance Imaging; Measures; Methadone; Microvascular Dysfunction; Modernization; Opioid; Opioid Analgesics; Pathway interactions; Patient Recruitments; Patient Self-Report; Persons; Pharmaceutical Preparations; Pilot Projects; Preventive; Recording of previous events; Research; Risk; Risk Assessment; Risk Factors; Stroke; Time; Tobacco; Tobacco use; Toxicology; Viral; Viral Load result; Woman; amphetamine use; antiretroviral therapy; base; cardiovascular disorder risk; cardiovascular risk factor; cerebrovascular; cocaethylene; cocaine use; disability; high risk; housing instability; improved; inflammatory marker; insight; mortality; multiple drug use; polysubstance use; predictive marker; recruit; response; risk stratification; safety net; stroke risk; stroke-like episode; substance use; tool

PROJECT SUMMARY/ABSTRACT Stroke is a major cause of disability and mortality, particularly in low-income individuals and people living with HIV (PLWH). It is associated with a variety of substances, including amphetamines, opiates, cannabis, alcohol, tobacco, and especially cocaine. However, most stroke studies do not account for drug use outside of alcohol or tobacco, and substance use is not included in stroke risk calculators. Our preliminary data suggest that cocaine use may influence mechanisms of stroke. If true, the consideration of cocaine use in stroke risk calculators could greatly improve risk assessment in PLWH who use drugs. We propose a new study to assess whether cocaine and polydrug use, in combination with inflammation, are significantly associated with stroke and mechanisms of stroke. The study will be one of very few to recruit participants from both safety net HIV clinics and community-based settings. It will provide much needed information regarding factors that influence conditions preceding stroke in PLWH who use drugs.

项目总结/文摘