Cocaine use, viral suppression and precursors of stroke in HIV infection

HIV 感染中的可卡因使用、病毒抑制和中风前兆

• 批准号: 10401450
• 负责人: ELISE D. RILEY
• 金额: $ 80.52万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10401450
• 关键词: AIDS/HIV problem; Acute; Address; Age; Alcohol consumption; Alcohols; Amphetamines; Biological Markers; C-reactive protein; CD4 Lymphocyte Count; Cannabis; Cardiovascular Diseases; Chronic; Clinic; Clinical; Cocaine; Cocaine use disorder; Communities; Data; Detection; Diagnosis; Drug abuse; Drug usage; Failure; Functional disorder; Goals; HIV; HIV Infections; Homelessness; Individual; Infarction; Inflammation; Inflammatory; Levamisole; Lidocaine; Link; Low Income Population; Low income; Magnetic Resonance Imaging; Measures; Methadone; Microvascular Dysfunction; Modernization; Opioid; Opioid Analgesics; Pathway interactions; Patient Recruitments; Patient Self-Report; Persons; Pharmaceutical Preparations; Pilot Projects; Preventive; Recording of previous events; Research; Risk; Risk Assessment; Risk Factors; Stroke; Time; Tobacco; Tobacco use; Toxicology; Viral; Viral Load result; Woman; amphetamine use; antiretroviral therapy; base; cardiovascular disorder risk; cardiovascular risk factor; cerebrovascular; cocaethylene; cocaine use; disability; high risk; housing instability; improved; inflammatory marker; insight; mortality; multiple drug use; polysubstance use; predictive marker; recruit; response; risk stratification; safety net; stroke risk; stroke-like episode; substance use; tool

PROJECT SUMMARY/ABSTRACT Stroke is a major cause of disability and mortality, particularly in low-income individuals and people living with HIV (PLWH). It is associated with a variety of substances, including amphetamines, opiates, cannabis, alcohol, tobacco, and especially cocaine. However, most stroke studies do not account for drug use outside of alcohol or tobacco, and substance use is not included in stroke risk calculators. Our preliminary data suggest that cocaine use may influence mechanisms of stroke. If true, the consideration of cocaine use in stroke risk calculators could greatly improve risk assessment in PLWH who use drugs. We propose a new study to assess whether cocaine and polydrug use, in combination with inflammation, are significantly associated with stroke and mechanisms of stroke. The study will be one of very few to recruit participants from both safety net HIV clinics and community-based settings. It will provide much needed information regarding factors that influence conditions preceding stroke in PLWH who use drugs.

项目总结/摘要 中风是残疾和死亡的主要原因，特别是在低收入人群中， 艾滋病毒感染者（PLWH）。它与多种物质有关，包括 安非他明、鸦片、大麻、酒精、烟草，尤其是可卡因。但大多数 中风研究没有考虑酒精或烟草以外的药物使用， 不包括在中风风险计算器中。我们的初步数据表明，可卡因的使用可能 影响中风机制。如果这是真的，那么可卡因使用对中风风险的影响 计算器可以大大改善对使用药物的PLWH的风险评估。我们提出了一个新 研究评估可卡因和多种药物的使用，与炎症相结合， 与中风和中风机制显著相关。这项研究将是为数不多的 从安全网艾滋病毒诊所和社区环境中招募参与者。它将 提供关于影响中风前状况的因素的急需信息， 吸毒的艾滋病毒携带者。