Mentoring patient-oriented research on the health consequences of polydrug use

 描述(由申请人提供)：Elise Riley博士是加州大学旧金山分校医学系副教授。作为一名流行病学家，她与17名初级调查人员共同指导，并制定了一个长期的多学科研究计划，重点是艾滋病毒、药物使用、健康状况和极低收入人群的医疗服务使用。她目前由NIDA资助，进行一项关于艾滋病毒和多种药物使用对心脏损伤的影响的无家可归妇女健康研究。在这里，她建议扩大母体研究，纳入两个新的生物标记物结果，这将通过考虑多个生理途径来更好地了解心功能障碍。在这个扩大的研究主体中，莱利博士进一步建议同时加强她对早期职业临床医生和实习生的指导活动。拟议的活动利用了莱利博士当前项目提供的现有基础设施、数据和合作，以及NIH和加州大学旧金山分校的额外资源。总的来说，它们将为职业发展提供多种机会，为以患者为导向的研究人员提供强大的指导计划，以及专注于了解共生暴露和健康状况的新项目，以更好地为高度脆弱人群的医疗保健提供信息。

 DESCRIPTION (provided by applicant): Dr. Elise Riley is an Associate Professor in the Department of Medicine at the University of California, San Francisco. Trained as an epidemiologist, she has co-mentored 17 junior investigators and developed a longstanding multidisciplinary research program focused on HIV, drug use, health status and the use of health services in very low-income populations. She is currently funded by NIDA to conduct a homeless women's health study regarding the influences of HIV and polydrug use on cardiac injury. Here she proposes an expansion of the parent study to include two new biomarker outcomes, which will provide a better understanding of cardiac dysfunction through the consideration of multiple physiological pathways. Within this expanded body of research, Dr. Riley further proposes the concurrent augmentation of her mentoring activities for early career clinicians and trainees. The proposed activities leverage existing infrastructure, data and collaborations provided by Dr. Riley's current program, as well as additional NIH and UCSF resources. Collectively they will provide multiple opportunities for career development, a strong mentoring program for patient-oriented researchers and new projects that focus on understanding co-occurring exposures and health conditions to better inform health care delivery in highly vulnerable populations.