Cocaine use, viral suppression and precursors of stroke in HIV infection

项目摘要/摘要 中风是致残和死亡的主要原因，特别是在低收入个人和 艾滋病毒携带者(PLWH)它与多种物质有关，包括 安非他明、鸦片、大麻、酒精、烟草，尤其是可卡因。然而，大多数 中风研究没有考虑除酒精或烟草以外的药物使用，物质使用是 不包括在中风风险计算器中。我们的初步数据显示可卡因的使用可能 影响中风的机制。如果是真的，考虑在中风风险中使用可卡因 计算器可以极大地提高对使用药物的PLWH的风险评估。我们提出了一个新的 评估可卡因和多种药物的使用是否与炎症相结合的研究 与卒中及卒中机制显著相关。这项研究将是为数不多的研究之一 招募来自安全网艾滋病毒诊所和社区环境的参与者。会的 提供急需的有关影响中风前病情的因素的信息 吸毒的PLWH。

PROJECT SUMMARY/ABSTRACT Stroke is a major cause of disability and mortality, particularly in low-income individuals and people living with HIV (PLWH). It is associated with a variety of substances, including amphetamines, opiates, cannabis, alcohol, tobacco, and especially cocaine. However, most stroke studies do not account for drug use outside of alcohol or tobacco, and substance use is not included in stroke risk calculators. Our preliminary data suggest that cocaine use may influence mechanisms of stroke. If true, the consideration of cocaine use in stroke risk calculators could greatly improve risk assessment in PLWH who use drugs. We propose a new study to assess whether cocaine and polydrug use, in combination with inflammation, are significantly associated with stroke and mechanisms of stroke. The study will be one of very few to recruit participants from both safety net HIV clinics and community-based settings. It will provide much needed information regarding factors that influence conditions preceding stroke in PLWH who use drugs.