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Mentoring patient-oriented research on the health consequences of polydrug use

指导以患者为中心的关于多种药物使用的健康后果的研究

基本信息

批准号：
10438894
负责人：
ELISE D. RILEY
金额：
$ 18.83万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10438894
关键词：
Acquired Immunodeficiency Syndrome Address Alcohols Attention Biological Markers Blood Body mass index CD4 Lymphocyte Count California Catabolism Cerebrovascular Disorders Cessation of life Clinical Cocaine Cocaine use disorder Communicable Diseases Complement Consequences of HIV Data Drug Combinations Drug usage Environment Enzymes Epidemiologist Failure Functional disorder Funding Goals HIV HIV Infections Health Healthcare Immune Individual Infarction Inflammation Inflammatory Interview Investigation Knowledge Kynurenine Learning Link Low income Magnetic Resonance Imaging Measures Medicine Mentors Microvascular Dysfunction Modernization National Institute of Drug Abuse Opioid Analgesics Parents Pathway interactions Persons Pharmaceutical Preparations Physiological Postdoctoral Fellow Recommendation Research Research Personnel Research Project Grants Risk Risk Assessment San Francisco Science Stroke T-Cell Proliferation Time Tobacco Toxicology Training Tryptophan Tryptophan 2,3 Dioxygenase Universities Viral Viral Load result Visit Woman antiretroviral therapy cardiovascular risk factor career career development cerebrovascular clinical development cocaine use cost effective early-career faculty experience improved inflammatory marker insight interest mortality multiple drug use patient oriented research polysubstance use premature professor programs public health relevance recruit research and development response risk stratification skills stroke risk tool training opportunity virtual

项目摘要

ABSTRACT Dr. Elise Riley is a Professor in the Division of HIV, Infectious Diseases and Global Medicine at the University of California, San Francisco. Trained as an epidemiologist, she has mentored 57 postdoctoral fellows and early-career faculty throughout her career while simultaneously leading research focused on the health consequences of HIV and drug use. She is currently funded by NIDA to conduct a study regarding the influences of polydrug use, viral load and inflammation on small vessel disease in people living with HIV. Here she proposes an expansion of the parent study to include measures of tryptophan catabolism, which will provide a better understanding of cerebrovascular dysfunction through the consideration of multiple physiological pathways. Within this expanded investigation, Dr. Riley will continue growing and improving the content of her individual-level mentoring program. In parallel, she will partner with the UCSF Center for AIDS Research (CFAR) to create a new virtual mentoring module within the existing CFAR mentoring program. In combination, the proposed activities will provide multiple opportunities for training in patient-oriented research and career development for early career investigators.

抽象的 Elise Riley 博士是伦敦大学艾滋病毒、传染病和全球医学部门的教授加州大学旧金山分校。她接受过流行病学家培训，指导过 57 名患者她在整个职业生涯中担任博士后研究员和早期职业教师，同时领导研究重点是艾滋病毒和吸毒对健康的影响。她目前的资助是 NIDA 将开展一项关于多种药物使用、病毒载量和炎症影响的研究艾滋病毒感染者的小血管疾病。在这里，她建议扩大家长研究包括色氨酸分解代谢的测量，这将提供更好的通过考虑多种因素来了解脑血管功能障碍生理途径。在这项扩大的调查中，莱利博士将继续成长并改进她个人层面的指导计划的内容。与此同时，她将与加州大学旧金山分校艾滋病研究中心 (CFAR) 将在其中创建一个新的虚拟指导模块现有的 CFAR 指导计划。结合起来，拟议的活动将提供为早期患者提供以患者为中心的研究和职业发展培训的多种机会职业调查员。