Roybal Resource and Coordinating Center to Accelerate Translational Aging Research

这是PA-18-935下的申请：对现有NIH赠款的紧急竞争性修订已激活 根据特别利益通知（NOSI）：NIA行政补充和修订的可用性 2019年冠状病毒病（COVID-19）补充，以修订我们目前有效的R24：R24 AG 064191。 R24 Roybal协调中心的最初目的是提供战略领导， 协调，鼓舞人心的支持，和创造性的传播爱德华R。罗伊博中心我们提出了一个 对现有赠款进行竞争性修订，以满足即时传播需求，以帮助解决具体问题 Northwell Health COVID-19研究联盟的公共卫生危机。标题为“迅速 传播有关Northwell Health COVID-19+临床护理的科学进展，以影响健康和 美国人一生中的福利”。我们建议根据NOT-AG-20-022进行。 我们已就所有COVID-19疑似患者创建IRB批准的登记数据（“数据集市”）。的 数据集市包括所有临床、结果、实验室、社会人口统计学和地理特征， 被怀疑患有COVID 19、正在接受COVID 19检测或被诊断患有COVID 19的人。具体包括 回答有关如何检测、测试和管理的重要和紧迫的公共卫生问题所需的信息 患有这种疾病的患者。例如，它包括数千名接受机械通气的患者的数据 状态、使用羟氯喹、长期使用血管紧张素转换酶（ACE）抑制剂或 血管紧张素II受体阻滞剂，同情注射COVID-19康复者捐献的血清+ 患者，以及其他许多变量。Northwell是世界上最大的医疗保健系统， 国内的COVID-19患者。截至2020年4月3日，我们共有5700名COVID-19+确诊患者 (mean年龄，62.4岁; 39.7%女性; 20.1%西班牙裔; 23.7%非裔美国人）。诺斯韦尔健康公司是 纽约最大的学术卫生系统，拥有约4，844张病床和672张ICU病床， 为长岛、韦斯特切斯特和纽约市的大约1100万人提供服务。 由于预计大流行将延续几个季节，我们请求提供两年的支助， 确保这一流行病的长期和短期后果能够得到充分和透明的了解， 报道这一点至关重要，因为解决这一问题的社会、经济、体制和政策环境 2019冠状病毒病大流行可能会对人们的健康和福祉产生不同的影响， 易受伤害的社会和医疗群体，如老年痴呆症患者或其他相关痴呆症患者。我们有 数据、资源、领导意志和承诺来完成这一使命。这将是非常有影响力的， 迅速解决研究传播和诺斯韦尔医疗保健系统的生产力，以确保 其他医疗保健系统可以从我们学到的东西中受益，并继续学习解决这个问题 大流行病和解决护理方面的差距。

This is an application under PA-18-935: Urgent Competitive Revision to Existing NIH Grants activated under Notice of Special Interest (NOSI): NIA Availability of Administrative Supplements and Revision Supplements on Coronavirus Disease 2019 (COVID-19) to revise our currently active R24: R24AG064191. The original purpose of the R24 Roybal Coordinating Center is to provide strategic leadership, efficient coordination, inspired support, and creative dissemination for the Edward R. Roybal Centers. We propose a competitive revision to this existing grant to meet immediate dissemination needs to help address the specific public health crisis by the Northwell Health COVID-19 Research Consortium. It is entitled “Rapidly Disseminating Scientific Advances about Northwell Health COVID-19+ Clinical Care to Impact Health and Welfare of Persons across the Life Course in the United States.” We propose to do so under NOT-AG-20-022. We have created an IRB-approved registry data (“data mart”) on all COVID-19 suspected patients. The data mart includes all clinical, outcome, laboratory, socio-demographic, and geographic characteristics of persons presenting under suspicion for, being tested for, or diagnosed with COVID19. Specifically, it includes information needed to answer vital and urgent public health questions about how to detect, test, and manage patients with this disease. For example, it includes data from thousands of patients on mechanical ventilation status, use of hydroxychloroquine, chronic use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers, compassionate injection of serum donated from recovered COVID-19+ patients, as well as many other variables. Northwell is the healthcare system with the largest volume of COVID-19 patients in the country. As of April 3, 2020, we had a total of 5700 COVID-19+ confirmed patients (mean age, 62.4 years; 39.7% female; 20.1% Hispanic; 23.7% African American). Northwell Health is the largest academic health system in New York, with approximately 4,844 hospital beds and 672 ICU beds, serving approximately 11 million persons in Long Island, Westchester, and New York City. Because the pandemic is predicted to extend several seasons, we are requesting 2 years of support, to ensure that the long-term, as well as short-term, consequences of this pandemic can be fully and transparently reported. This is critical, because the social, economic, institutional, and policy environments addressing the COVID-19 pandemic may differentially impact the health and welfare of people across the life course and in vulnerable social and medical groups, such as those with Alzheimers or other related dementias. We have the data, resources, leadership will, and commitment to accomplish this mission. It would be highly impactful to rapidly address the research dissemination and productivity of the Northwell healthcare system to ensure that other healthcare systems can benefit from what we have learned and continue to learn in addressing this pandemic and addressing disparities in care.