Adult Changes in Thought (ACT) Research Program Core C: Life Course Core

核心C：生命历程核心 项目总结 成人思维变化(ACT)U19研究计划的首要目标是使用一个生命过程 调查影响认知和阿尔茨海默病的可改变因素和其他因素的方法 与痴呆症相关，包括更好地理解潜在的机制。生活课程核心提供 这一目标的数据和理论支持。核心利用现有的凯撒永久华盛顿 (KPWA)电子数据文件和医疗记录、现有的ACT数据、新的调查仪器以及 公有领域。通过有效地建立作为长期纵向队列的ACT的广泛资源 建立在医疗保健提供系统中的生命课程核心将支持科学研究，以增强我们的 了解衰老，特别是脑老化、痴呆症和阿尔茨海默病。跨学科 拥有生命周期流行病学、建筑环境、神经科学和健康政策方面专业知识的核心团队 计量经济学将在所有项目和核心活动中支持生命周期框架。《生命历程》 核心的具体目标是：目标1)聚合来自不同来源的数据(包括管理 调查问卷和与外部数据来源的联系)，以描述生命过程中的社会经济状况； 目的2)检验大脑发育和功能的特定关键时期决定时间的假说 个人和地区一级的社会经济状况指标与晚年认知轨迹的相关性； 以及目标3)协助项目从新收集的和 现有变量并与核心合作，将最具影响力的变量整合到他们的分析中，以 了解强健认知功能对痴呆症的影响。整合新的社会和健康数据 生命周期将允许此核心与其他核心合作，以支持三个项目的AIMS和 更广泛的科学努力。我们将与临床核心和数据密切合作，并 分析核心分别用于收集和共享数据。生命课程核心在U19中发挥着核心作用 通过提供主题统一，将改变ACT U19计划科学的未来价值。

CORE C: LIFE COURSE CORE PROJECT SUMMARY The Adult Changes in Thought (ACT) U19 Research Program’s overarching goal is to use a life course approach to investigate modifiable and other factors that influence cognition and Alzheimer’s disease and related dementia, including better understanding of underlying mechanisms. The Life Course Core provides data and theoretical support for this goal. The Core leverages existing Kaiser Permanente Washington (KPWA) electronic data files and medical records, existing ACT data, new survey instruments, and data in the public domain. By efficiently building on the extensive resources of ACT as a long-standing longitudinal cohort set in a health care delivery system, the Life Course Core will support scientific inquiry to enhance our understanding of aging, especially brain aging and dementia and Alzheimer’s disease. The interdisciplinary Core team with expertise in life course epidemiology, the built environment, neuroscience, and health policy and econometrics will support the life course framework in all Projects and Core activities. The Life Course Core’s Specific Aims are: Aim 1) To aggregate data from disparate sources (including administration of a questionnaire and linkage to external data sources) to characterize socioeconomic status over the life course; Aim 2) To test the hypothesis that specific crucial times in brain development and function determine the timing of the relevance of individual and area level socioeconomic status indicators to cognitive trajectories in late life; and Aim 3) To assist the Projects in identifying relevant life course parameters from newly collected and existing variables and partner with Cores to integrate the most influential variables into their analyses to understand the spectrum of robust cognitive function to dementia. Integrating new social and health data over the life course will allow this Core to work with other cores to support aims across the three Projects and broader scientific endeavors. We will work particularly closely with the Clinical Core and the Data and Analysis Core to collect and share data, respectively. The Life Course Core serves a central role in the U19 by providing thematic unification that will transform the future value of ACT U19 Program science.