Physical activity, sedentary behavior, and sleep in the ACT cohort: The 24-hour activity cycle

ACT 队列中的体力活动、久坐行为和睡眠：24 小时活动周期

• 批准号: 10404978
• 负责人: Dori E Rosenberg
• 金额: $ 63.8万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404978
• 关键词: Accelerometer; Activities of Daily Living; Activity Cycles; Adult; Age-associated memory impairment; Aging; Alzheimer' s Disease; Beds; Behavior; Behavioral; Brain; Cardiovascular Diseases; Circadian Rhythms; Clinical; Cognition; Cognitive; Collaborations; Collection; Complement; Complex; Data; Data Analyses; Data Collection; Dementia; Development; Devices; Education; Elderly; Energy Metabolism; Equilibrium; Future; Gait speed; Goals; Guidelines; Hand Strength; Health; Heterogeneity; Hour; Image; Impaired cognition; Income; Individual; Information Systems; Intervention; Joints; Life; Life Cycle Stages; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Metabolic syndrome; Modeling; Monitor; Mood Disorders; Outcome; Participant; Patient Outcomes Assessments; Patient Self-Report; Pattern; Phase; Physical Function; Physical activity; Population; Research; Resources; Risk; Sleep; Sleep disturbances; Testing; Thigh structure; Time; Work; Wrist; actigraphy; adverse childhood events; age related; base; cognitive ability; cognitive function; cohort; comorbidity; data resource; diaries; executive function; functional independence; healthy aging; immune function; improved; innovation; instrument; neuroimaging; novel; physical conditioning; programs; response; screening; sedentary lifestyle; sex; sleep behavior; sleep quality; theories; vigorous intensity

Physical activity (PA), sedentary behavior (SB), and sleep all impact cognitive and physical health in aging. Most research to date has focused on how time spent in each of these behaviors individually impacts health outcomes. However, interactions of PA, SB, and sleep likely account in part for the tremendous heterogeneity in aging-related health outcomes, and their optimal balance across the 24-hour day in supporting healthy aging is not known. This proposal capitalizes upon unique resources available through the Adult Changes in Thought (ACT) U19 Program to explore the inter-relatedness of PA, SB, sleep, and longitudinal trajectories of cognitive and physical health. The 24-hour activity cycle paradigm as a model for determining longitudinal inter- relatedness of PA, SB, and sleep on health outcomes is innovative, as is our proposed collection of device- based data to complement self-reported outcomes. This project proposes to use a number of innovative statistical approaches to analyze the complex relationships between the 24-hour activity cycle and trajectories of cognition and physical functioning. Scientific rigor is supported by objective monitoring of 24-hour behaviors and builds upon more than two decades of ACT data in a well-characterized clinical population. Measures of cognitive and physical function will include Cognitive Abilities Screening Instrument item response theory scores, specialized tests of executive functioning and verbal fluency, self-reported activities of daily living, gait speed, rising from a chair, and grip strength. For Aim 1, we will test bidirectional associations relating cognitive and physical function to the 24-hour activity cycle using device-assessed measures of PA and SB, and self- reported sleep. We hypothesize that (a) historically better cognitive and physical function will be independently associated with higher levels of PA, lower SB, and better sleep in ACT participants, and (b) more PA, less SB, and better sleep will be independently associated with better future maintenance of cognitive and physical function. For Aim 2, we hypothesize that (a) historically better cognitive and physical function will be independently associated with better device-assessed sleep quality and circadian rhythms in ACT participants, and (b) better device-assessed sleep quality and circadian rhythms will be independently associated with better future maintenance of cognitive and physical function. For both Aims, we will construct combined 24- hour activity cycle profiles (based on different balances of PA, SB, and sleep) and explore how profiles are associated with historical trajectories of and future changes in cognitive and physical function. Collaboration with other Cores will provide new data about how Life Course and Clinical Core variables influence associations, as well as new information about relationships between the 24-hour activity cycle and novel neuroimaging data. Ultimately, our results will provide much needed evidence to inform the development of guidelines and interventions to promote healthy aging in older adults, potentially including reducing risk for cognitive decline and late life dementia including Alzheimer’s disease.

身体活动（PA）、久坐行为（SB）和睡眠都会影响衰老过程中的认知和身体健康。 迄今为止，大多数研究都集中在这些行为所花费的时间如何单独影响健康 结果。然而，PA、SB 和睡眠的相互作用可能在一定程度上解释了巨大的异质性 与衰老相关的健康结果，以及它们在支持健康衰老方面的全天 24 小时最佳平衡 尚不清楚。该提案利用了成人思想转变提供的独特资源 (ACT) U19 项目探索 PA、SB、睡眠和认知纵向轨迹的相互关系 和身体健康。 24 小时活动周期范式作为确定纵向间的模型 PA、SB 和睡眠与健康结果的相关性是创新的，我们建议的设备集合也是如此。 基于数据来补充自我报告的结果。该项目拟采用多项创新技术 统计方法来分析 24 小时活动周期和轨迹之间的复杂关系 认知和身体机能。 24小时行为客观监测支持科学严谨 并建立在二十多年的 ACT 数据的基础上，这些数据均经过充分表征的临床人群。措施 认知和身体功能将包括认知能力筛查仪器项目反应理论 分数、执行功能和语言流畅性的专门测试、自我报告的日常生活活动、步态 速度、从椅子上站起来和握力。对于目标 1，我们将测试与认知相关的双向关联 使用 PA 和 SB 的设备评估测量以及自我评估来评估 24 小时活动周期的身体机能 报告睡眠。我们假设（a）历史上更好的认知和身体功能将独立地 与 ACT 参与者较高的 PA 水平、较低的 SB 和更好的睡眠有关，并且 (b) 更多的 PA，更少的 SB， 更好的睡眠将与未来更好地维持认知和身体独立相关 功能。对于目标 2，我们假设 (a) 历史上更好的认知和身体功能将是 与 ACT 参与者更好的设备评估睡眠质量和昼夜节律独立相关， (b) 更好的设备评估睡眠质量和昼夜节律将与 更好地维护未来的认知和身体功能。对于这两个目标，我们将构建组合的 24- 小时活动周期概况（基于 PA、SB 和睡眠的不同平衡）并探索概况如何 与认知和身体功能的历史轨迹和未来变化相关。合作 与其他核心将提供有关生命历程和临床核心变量如何影响的新数据 关联，以及有关 24 小时活动周期和小说之间关系的新信息 神经影像数据。最终，我们的结果将为开发提供急需的证据 促进老年人健康老龄化的指南和干预措施，可能包括降低老年风险 认知能力下降和晚年痴呆症，包括阿尔茨海默病。