Physical activity, sedentary behavior, and sleep in the ACT cohort: The 24-hour activity cycle

ACT 队列中的体力活动、久坐行为和睡眠：24 小时活动周期

• 批准号: 10404978
• 负责人: Dori E Rosenberg
• 金额: $ 63.8万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404978
• 关键词: Accelerometer; Activities of Daily Living; Activity Cycles; Adult; Age-associated memory impairment; Aging; Alzheimer' s Disease; Beds; Behavior; Behavioral; Brain; Cardiovascular Diseases; Circadian Rhythms; Clinical; Cognition; Cognitive; Collaborations; Collection; Complement; Complex; Data; Data Analyses; Data Collection; Dementia; Development; Devices; Education; Elderly; Energy Metabolism; Equilibrium; Future; Gait speed; Goals; Guidelines; Hand Strength; Health; Heterogeneity; Hour; Image; Impaired cognition; Income; Individual; Information Systems; Intervention; Joints; Life; Life Cycle Stages; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Metabolic syndrome; Modeling; Monitor; Mood Disorders; Outcome; Participant; Patient Outcomes Assessments; Patient Self-Report; Pattern; Phase; Physical Function; Physical activity; Population; Research; Resources; Risk; Sleep; Sleep disturbances; Testing; Thigh structure; Time; Work; Wrist; actigraphy; adverse childhood events; age related; base; cognitive ability; cognitive function; cohort; comorbidity; data resource; diaries; executive function; functional independence; healthy aging; immune function; improved; innovation; instrument; neuroimaging; novel; physical conditioning; programs; response; screening; sedentary lifestyle; sex; sleep behavior; sleep quality; theories; vigorous intensity

Physical activity (PA), sedentary behavior (SB), and sleep all impact cognitive and physical health in aging. Most research to date has focused on how time spent in each of these behaviors individually impacts health outcomes. However, interactions of PA, SB, and sleep likely account in part for the tremendous heterogeneity in aging-related health outcomes, and their optimal balance across the 24-hour day in supporting healthy aging is not known. This proposal capitalizes upon unique resources available through the Adult Changes in Thought (ACT) U19 Program to explore the inter-relatedness of PA, SB, sleep, and longitudinal trajectories of cognitive and physical health. The 24-hour activity cycle paradigm as a model for determining longitudinal inter- relatedness of PA, SB, and sleep on health outcomes is innovative, as is our proposed collection of device- based data to complement self-reported outcomes. This project proposes to use a number of innovative statistical approaches to analyze the complex relationships between the 24-hour activity cycle and trajectories of cognition and physical functioning. Scientific rigor is supported by objective monitoring of 24-hour behaviors and builds upon more than two decades of ACT data in a well-characterized clinical population. Measures of cognitive and physical function will include Cognitive Abilities Screening Instrument item response theory scores, specialized tests of executive functioning and verbal fluency, self-reported activities of daily living, gait speed, rising from a chair, and grip strength. For Aim 1, we will test bidirectional associations relating cognitive and physical function to the 24-hour activity cycle using device-assessed measures of PA and SB, and self- reported sleep. We hypothesize that (a) historically better cognitive and physical function will be independently associated with higher levels of PA, lower SB, and better sleep in ACT participants, and (b) more PA, less SB, and better sleep will be independently associated with better future maintenance of cognitive and physical function. For Aim 2, we hypothesize that (a) historically better cognitive and physical function will be independently associated with better device-assessed sleep quality and circadian rhythms in ACT participants, and (b) better device-assessed sleep quality and circadian rhythms will be independently associated with better future maintenance of cognitive and physical function. For both Aims, we will construct combined 24- hour activity cycle profiles (based on different balances of PA, SB, and sleep) and explore how profiles are associated with historical trajectories of and future changes in cognitive and physical function. Collaboration with other Cores will provide new data about how Life Course and Clinical Core variables influence associations, as well as new information about relationships between the 24-hour activity cycle and novel neuroimaging data. Ultimately, our results will provide much needed evidence to inform the development of guidelines and interventions to promote healthy aging in older adults, potentially including reducing risk for cognitive decline and late life dementia including Alzheimer’s disease.

身体活动（PA），久坐行为（SB）和睡眠都会影响衰老的认知和身体健康。 迄今为止，大多数研究都集中在这些行为中的每一种行为所花费的时间如何单独影响健康 结果。然而，PA，SB和睡眠的相互作用可能部分解释了这种巨大的异质性。 在与衰老相关的健康结果中，以及它们在24小时内支持健康衰老的最佳平衡 是未知的。这项建议利用了通过成人思想变化可获得的独特资源 (ACT)U19项目旨在探索PA、SB、睡眠和认知的纵向轨迹的相互关系 和身体健康。24小时活动周期范式作为一种模型，用于确定纵向间- PA、SB和睡眠对健康结果的相关性是创新的，我们提出的设备集合也是如此， 以补充自我报告的结果。该项目建议使用一些创新的 统计方法分析24小时活动周期和轨迹之间的复杂关系 认知和身体功能的变化。科学的严谨性得到了对24小时行为的客观监测的支持 并建立在二十多年的ACT数据在一个良好的特点临床人群。措施 认知和身体功能将包括认知能力筛查工具项目反应理论 分数，执行功能和语言流畅性的专门测试，自我报告的日常生活活动，步态 速度，从椅子上站起来，和握力。对于目标1，我们将测试与认知相关的双向关联， 和身体功能的24小时活动周期，使用PA和SB的设备评估措施， 报告睡眠。我们假设（a）历史上更好的认知和身体功能将独立于 与ACT参与者中较高水平的PA、较低的SB和较好的睡眠相关，以及（B）较多的PA，较少的SB， 更好的睡眠将与未来更好地维持认知和身体健康独立相关。 功能对于目标2，我们假设（a）历史上更好的认知和身体功能将是 与ACT参与者更好的设备评估睡眠质量和昼夜节律独立相关， 以及（B）更好的设备评估的睡眠质量和昼夜节律将独立地与以下因素相关： 更好地维持未来的认知和身体功能。为了实现这两个目标，我们将建立24- 小时活动周期曲线（基于PA、SB和睡眠的不同平衡），并探索曲线如何 与认知和身体功能的历史轨迹和未来变化相关。协作 将提供关于生命过程和临床核心变量如何影响 协会，以及关于24小时活动周期和小说之间关系的新信息。 神经成像数据。最终，我们的研究结果将提供急需的证据，为发展提供信息。 促进老年人健康老龄化的指南和干预措施，可能包括降低老年人 认知能力下降和老年痴呆症，包括阿尔茨海默病。