De Pié y a Movernos Study: Promoting physical activity in older Latinx adults

摘要 拉美裔老年人患阿尔茨海默病和相关痴呆(ADRD)的风险比 白人老年人。尽管拉丁裔老年人的体力活动率(PA)较低，但 与ADRD相关的合并症，很少有研究针对这一人群进行基于理论和 文化适应的方法，以降低ADRD的风险。在小组试验工作的基础上，拟议的 该项目将允许我们在文化上采用基于理论的干预措施，以促进中等到剧烈的身体锻炼 55岁至89岁拉丁裔成年人的活动(MVPA)。在第一阶段(R61/AIM 1)，我们将最终确定招募工作 和干预战略(包括最终确定遵守MVPA的目标机制、初始文化 改编和翻译)，通过与我们的社区咨询委员会的会议和10 拉丁裔成年人。在第二阶段(R33/AIM 2)，我们将随机选择130名拉丁裔成年人接受为期16周的完全远程治疗 De Piéy是Movernos(De Pié)干预或控制条件。干预将以机制为目标 自我效能感、PA习惯强度、社会支持和PA享受使用阶梯方法 参与者最初将通过更多的活动来建立参与MVPA的信心，从而减少坐着的时间。 参与者还将收到Fitbit活动跟踪器、健康指导联系人、会议目标反馈以及 将确定一名支持人员。我们将确定De Pié干预对激活型PAL的影响 基于加速度计的MVPA分钟/天(主要结果)以及遵守MVPA指南 每周150分钟(次要结果)。此外，将进行调解分析，以确定 干预对依恋机制(自我效能感、习惯强度、社会支持、享受性)的影响 并确定这些机制是否解释了干预对MVPA每周分钟数的影响以及对 MVPA指南。我们将探索认知、文化适应、年龄和性别作为这些联系的调节因素。 结果将有助于确定遵守MVPA的重要机制，并为适应文化的理论提供信息。 在拉丁裔社区预防ADRD的基于方法。

SUMMARY Latinx older adults are at higher risk for developing Alzheimer’s Disease and Related Dementias (ADRD) than White older adults. Despite older Latinx adults having lower rates of physical activity (PA) and a high burden of comorbidities that are associated with ADRD, few studies have targeted this population with theory-based and culturally adapted approaches to reduce risk for ADRD. Building on pilot work by the team, the proposed project would allow us to culturally adapt a theory-based intervention to promote moderate-to-vigorous physical activity (MVPA) for Latinx adults ages 55 to 89 years. In Stage I (R61/Aim 1), we will finalize the recruitment and intervention strategy (including finalizing the target mechanisms of adherence to MVPA, initial cultural adaptation and translation) through meetings with our community advisory board and pilot testing with 10 Latinx adults. In Stage II (R33/Aim 2), we will randomize 130 Latinx adults to receive the 16-week, fully remote De Pié y a Movernos (De Pié) intervention or a control condition. The intervention will target the mechanisms of self-efficacy, PA habit strength, social support, and PA enjoyment using a staircase approach where participants will initially reduce their sitting by moving more to build confidence towards engaging in MVPA. Participants will also receive a Fitbit activity tracker, health coaching contacts, feedback on meeting goals, and will identify a support person. We will determine the effect of the De Pié intervention on activPAL accelerometer-based MVPA minutes/day (primary outcome) and adherence to meeting the MVPA guidelines of 150 minutes per week (secondary outcome). Further, mediation analyses will be conducted to determine the effect of the intervention on mechanisms of adherence (self-efficacy, habit strength, social support, enjoyment) and identify whether these mechanisms explain intervention effects on MVPA minutes/week and adherence to MVPA guidelines. We will explore cognition, acculturation, age and sex as moderators of these associations. Results will help identify important mechanisms of adherence to MVPA and inform culturally adapted, theory- based approaches to prevent ADRD in the Latinx community.