Annual Adult Changes in Thought (ACT) symposium on aging, dementia, and Alzheimer's disease

项目概要/摘要 近600万美国成年人目前患有阿尔茨海默病（AD），其中70万人将在2020年1月1日至2020年3月30日期间接受治疗。 在2019年独自死去。没有简单的预防、早期发现或治愈方法。1994年，成人 思想变化（ACT）研究收集了5500多例患者的观察、临床和实验室数据。 老年人，并随着时间的推移跟踪他们的痴呆症和阿尔茨海默病的迹象。ACT数据 有助于一个生活，学习实验室，作为研究界的科学资源。为 在过去的七年里，我们每年都举办ACT研讨会，展示新的ACT资源，突出 创新的研究成果，分享新的资助理念，促进跨学科合作。每年 我们在研讨会后的评估中得到了更高的评价，去年的与会者中有98%的人 表示他们会向其他人推荐研讨会，100%表示他们会参加未来的研讨会。 ACT研讨会。但是，如果没有会议补助金，我们没有能力举办今后的专题讨论会 经费本次会议赠款将提供支持，继续和发展的ACT研讨会在未来五年 年我们的会议补助金的具体目标是：1）促进科学使用和理解 ACT数据; 2）促进跨学科，机构和研究的合作; 3）提供 对正在进行的和计划中的工作（如正在进行的分析或新的赠款想法）提供反馈的机会， 特别是对于初级调查员。这笔资金将使我们能够在一个大型的，方便的 先进的视听设备。它还将为初级研究人员提供旅行津贴， 来自代表性不足的少数群体的调查人员，以及来自外地的研究人员， 可能会让我们接触到新的外部调查员未来的会议将涵盖老龄化的关键主题， 痴呆症研究，如恢复力，成像，痴呆亚型，分子表型，创伤性脑 伤害，以及其他。从长远来看，继续和扩大ACT研讨会将增加ACT生活的使用 实验室，并提供一个创造性的，欢迎的空间，为顶级研究人员交流创新的研究 并加速AD和脑老化研究。

Project Summary/Abstract Nearly 6 million U.S. adults are currently living with Alzheimer’s disease (AD), and 700,000 of these people will die in 2019 alone. There is no simple solution for prevention, early detection, or cure. Since 1994, the Adult Changes in Thought (ACT) study has collected observational, clinical, and laboratory data on more than 5,500 older adults and is following them over time for signs of dementia and Alzheimer’s disease. ACT data contribute to a living, learning laboratory, which serves as a scientific resource for the research community. For the past seven years, we have held an annual ACT symposium to showcase new ACT resources, highlight innovative research findings, share new grant ideas, and promote cross-disciplinary collaborations. Every year we have received higher ratings on our post-symposium evaluations, with 98% of last year’s attendees indicating they would recommend the symposium to others and 100% indicating they would attend a future ACT symposium. However, we do not have the capacity to hold future symposia without conference grant funding. This conference grant will provide support to continue and grow the ACT symposia over the next five years. The specific objectives of our conference grant are to: 1) promote scientific use and understanding of ACT data; 2) promote collaborations across scientific disciplines, institutions, and studies; and 3) provide opportunities for feedback on ongoing and planned work such as analyses-in-progress or new grant ideas, particularly for junior investigators. This funding will allow us to host the symposium in a large, accessible venue with advanced audiovisual equipment. It also will provide travel stipends for junior researchers, investigators from underrepresented minority groups, and researchers traveling from out of town so that we may extend our reach to new external investigators. Future conferences will cover critical topics in aging and dementia research such as resilience, imaging, dementia subtypes, molecular phenotypes, traumatic brain injury, and others. Long term, continuing and expanding the ACT symposia will increase use of the ACT living laboratory and provide a creative, welcoming space for top investigators to exchange innovative research ideas and accelerate AD and brain aging research.