Adult Changes in Thought (ACT) Research Program Core A: Administrative Core

成人思维变化(ACT)U19研究计划的总体目标是：(1)扩展ACT 队列登记，改善的随访，生命过程风险因素的表型，以及新的神经成像和 神经病理学结果；(2)支持研究阿尔茨海默氏症和老年痴呆症的健康功能谱的项目 老年人的相关痴呆症；以及(3)扩大和改进ACT的数据和资源传播，以 研究界。为了实现这些目标，ACT U19计划包括三项科学研究 项目、六个资源核心、一个外部咨询委员会、几个委员会和许多机构合作伙伴。 核心A：行政核心是必需的组成部分，将为 整个ACT U19计划。行政核心将支持所有项目和核心进行有效研究 通过提供基于团队的领导、明确的时间表、可衡量的里程碑、 和行政政策。我们将创建私人和公共网站，并计划在整个计划范围内进行互动 保持开放沟通、协作、传播和资源共享的活动。这个 管理核心将促进与新调查人员的合作和支持机制，以 有意义地共享ACT U19计划数据。这些机制包括一个最先进的公共网站， 具有清晰文档的可下载数据集；协作维护的大型、严格的ACT存储库 与数据和分析核心支持标准化的数据共享；支持在线数据查询工具 初步汇总数据请求；新数据的可靠行政流程和程序 请求。重要的是，我们将与数据和分析核心合作，以监督物流、流动和跟踪 ACT存储库中的所有参与者数据、项目和核心之间的数据以及任何与ACT相关的辅助数据 学习。行政核心将为ACT U19计划的后勤和 财务要求。这包括监督日常活动；与国家 老龄研究所、外部咨询委员会和支持委员会；以及制定该计划的政策， 治理、沟通方法和行政程序。最后，我们将进行一年两次的 评估以提高ACT U19计划的绩效。评估的重点将是一体化的程度， 整个U19计划的通信质量和科学生产力，以促进最佳实践 在沟通、管理和实施研究活动方面。行政核心是 我们ACT U19计划的运营骨干，并包括一支强大的高级领导团队，其中包括几名 小型、灵活的委员会，有效地管理所有项目和核心的工作。我们将实现现代化和 改进我们现行的许多行政程序和政策，以确保从U01平稳过渡 更大的U19计划。鉴于我们之前在领导、协作和研究项目方面的经验 通过协调，我们相信这一管理核心能够引领ACT U19计划取得成功。

The overall goals of the Adult Changes in Thought (ACT) U19 Research Program are to (1) expand ACT cohort enrollment with improved follow-up, phenotyping of life course risk factors, and new neuroimaging and neuropathology outcomes; (2) support Projects studying the spectrum of healthy functioning to Alzheimer’s and related dementias in older adults; and (3) expand and improve ACT’s dissemination of data and resources to the research community. To accomplish these goals, the ACT U19 Program includes three scientific research Projects, six resource Cores, an External Advisory Board, several committees, and many institutional partners. Core A: Administrative Core is a required component and will provide overall leadership and oversight to the entire ACT U19 Program. The Administrative Core will support all Projects and Cores in effective research organization and communication by providing team-based leadership, clear timelines, measurable milestones, and administrative policies. We will create private and public websites and plan interactive Program-wide activities to maintain open communication, collaboration, dissemination, and resource sharing. The Administrative Core will facilitate collaborations with new investigators and support mechanisms to meaningfully share ACT U19 Program data. These mechanisms include a state-of-the-art public website with downloadable datasets with clear documentation; a large, rigorous ACT repository maintained in collaboration with the Data and Analysis Core to support standardized data sharing; an online Data Query Tool to support preliminary aggregate data requests; and reliable administrative processes and procedures for new data requests. Importantly, we will work with the Data and Analysis Core to oversee the logistics, flow, and tracking of all participant data in the ACT Repository, between Projects and Cores, and with any ACT-related ancillary studies. The Administrative Core will provide centralized support of the ACT U19 Program’s logistic and financial requirements. This includes overseeing day-to-day activities; communicating with the National Institute on Aging, External Advisory Board, and supporting committees; and setting the Program’s policies, governance, communication methods, and administrative procedures. Finally, we will undertake a biannual evaluation to improve ACT U19 Program performance. The evaluation will focus on the extent of integration, quality of communication, and scientific productivity across the entire U19 Program to promote best practices in communication, administration, and implementation of research activities. The Administrative Core is the operational backbone of our ACT U19 Program and includes a strong senior leadership team with several small, nimble committees to effectively manage work across all Projects and Cores. We will modernize and improve many of our current administrative procedures and policies to ensure a smooth transition from the U01 to the larger U19 Program. Given our prior experience in leadership, collaboration, and research project coordination, we are confident that this Administrative Core can lead the ACT U19 Program to success.