Slow wave sleep (SWS) and the effect of African ancestry on amyloid burden, a longitudinal study
慢波睡眠 (SWS) 和非洲血统对淀粉样蛋白负担的影响,一项纵向研究
基本信息
- 批准号:10405035
- 负责人:
- 金额:$ 130.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:African American populationAfrican ancestryAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAlzheimer&aposs disease riskAmyloidAmyloid beta-ProteinAmyloid depositionApneaAtrophicAutopsyBehaviorBlack raceBlood VesselsBody mass indexBreathingCardiovascular systemCharacteristicsChurchClinicalCognitionCognitiveCommunitiesCommunity OutreachConsultationsDataDementiaDevelopmentDevicesDiabetes MellitusDiffusionDiseaseEducationElderlyEthnic OriginEvaluationExcessive Daytime SleepinessGeneticGeographic LocationsGoalsHealthHealthcareHeritabilityHigh PrevalenceHomeHypertensionImageImpaired cognitionIncomeLesionLongitudinal StudiesMeasuresMedialMedicalMemoryMinority EnrollmentMonitorMorbidity - disease rateNeighborhoodsNerve DegenerationNeuropsychological TestsNot Hispanic or LatinoObesityOutcomeParticipantPathologyPatientsPhysiologicalPolysomnographyPopulationPositron-Emission TomographyPrevalencePreventionPsychosocial FactorREM SleepRaceReportingResearchRiskRisk FactorsScanningSleepSleep FragmentationsSleep StagesSleep disturbancesSlow-Wave SleepStressTestingTimeVascular DiseasesVisitWorkactigraphybasecerebrovascularclinical predictorscognitive testingexecutive functionexperiencefallshealth inequalitieshigh riskin vivoindexinginnovationmild cognitive impairmentnon-dementednovelpoor sleepracial differencerecruitresearch clinical testingsexsleep healthsleep quantitysocial stressorsociodemographic variablesuptakevascular risk factorway findingwhite matterβ-amyloid burden
项目摘要
7. PROJECT SUMMARY/ABSTRACT:
African-Americans (AAs) have an increased prevalence of Alzheimer's disease (AD) compared to whites,
which traditionally has been associated to the presence of vascular disease. However, a recent community-
based study of non-demented elderly, as well as our preliminary data, suggest that AAs have higher amyloid
burden after adjusting for vascular risk factors, which points to the presence of additional genetic or
physiological differences on AD-risk by race. The purpose of this study is to test whether poor slow wave sleep
(SWS) is one of these factors. Sleep disturbances vary between AAs and non-Hispanic whites. AAs take longer
to fall asleep, have shorter sleep duration, lower sleep efficiency and, more characteristically, less SWS duration
when compared to whites. Relatedly, amyloid positive healthy elderly, as well as those with mild cognitive
impairment (MCI) and AD, experience more sleep fragmentation and more decreased SWS and REM sleep
duration than their healthy counterparts. This suggests: i) that disturbed sleep contributes to AD-
neurodegeneration (or that sleep is particularly sensitive to amyloid deposition); and, ii) that race-related sleep
differences might contribute to the reported increases in amyloid burden in AAs. The study has two goals: first,
to confirm that black race is associated in vivo with longitudinal increases in amyloid-PET uptake and
cognitive decline; second, to demostrate that poor SWS at baseline is associated with these increases after
controling for the cardiovascular morbidity that is shared between sleep disturbances and dementia and might
confound these associations. In consultation with community stakeholders, we will recruit 150 cognitively
normal AA elderly (ages 55-75 years) and 60 whites balanced by age, sex, BMI, education and other socio-
demographic variables and from the same Brooklyn neighborhoods. Visit one will include a full clinical
evaluation, neuropsychological tests and clinical labs. Participants will later undergo home monitoring for OSA
for two nights followed by 5 days of actigraphy. Subjects with normal sleep breathing will be invited to perform
2 nights of nocturnal polysomnography (NPSG) followed by a second final visit in which amyloid load and
cerebrovascular morbidity will be analyzed by 11C-PiB PET-MR. All subjects will be invited to repeat both visits
after 30 months. This study has the potential to identify clinical predictors of amyloid burden in cognitively
normal AA elderly and would be an important step towards the prevention of dementia in the black community
as well as the reduction of health inequities.
7.项目摘要/摘要:
与白人相比,非洲裔美国人(AA)阿尔茨海默病(AD)的患病率更高,
这在传统上被认为与血管疾病的存在有关。然而,最近的一个社区-
基于对非痴呆症老年人的研究,以及我们的初步数据,表明AA有更高的淀粉样蛋白
在调整了血管危险因素后的负担,这表明存在额外的遗传或
不同种族对AD风险的生理差异。这项研究的目的是测试慢波睡眠差
(SWS)是这些因素之一。AAA和非西班牙裔白人之间的睡眠障碍有所不同。AAS耗时更长
入睡,睡眠时间较短,睡眠效率较低,更有特点的是,SWS持续时间较短
与白人相比。与此相关的是,淀粉样蛋白阳性的健康老年人以及轻度认知障碍的老年人
损害(MCI)和AD,经历更多的睡眠碎片,更多的SWS和REM睡眠减少
持续时间比健康的同龄人要长。这表明:i)睡眠障碍会导致AD--
神经变性(或睡眠对淀粉样蛋白沉积特别敏感);以及,ii)与种族有关的睡眠
差异可能是报道的AA患者淀粉样蛋白负荷增加的原因。这项研究有两个目标:第一,
为了确认体内黑色人种与淀粉样蛋白-PET摄取的纵向增加和
认知能力下降;第二,说明基线时较差的主观幸福感与之后的这些增加有关
控制睡眠障碍和痴呆症之间共有的心血管发病率
混淆这些联想。在与社区利益相关者协商后,我们将招聘150名认知人员
正常的AA老年人(年龄55-75岁)和60名白人,按年龄、性别、BMI、教育和其他社会因素进行平衡
人口统计变量和来自布鲁克林的相同社区。探访一次将包括完整的临床
评估、神经心理测试和临床实验室。参与者稍后将接受OSA的家庭监测
两个晚上,然后是5天的动作记录。睡眠呼吸正常的受试者将被邀请表演
2个晚上的夜间多导睡眠监测(NPSG),然后进行第二次最后一次检查,其中淀粉样蛋白负荷和
脑血管患病率将通过11C-PIB PET-MR进行分析。所有受试者将被邀请重复这两次访问
30个月后。这项研究有可能从认知角度确定淀粉样蛋白负荷的临床预测因素。
这将是黑人社区预防痴呆症的重要一步
以及减少健康方面的不平等。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Girardin Jean-Louis其他文献
Girardin Jean-Louis的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Girardin Jean-Louis', 18)}}的其他基金
Promoting Academic Workforce Diversity in Translational Behavioral & Cardio-Metabolic Research (PINNACLE)
促进转化行为学术队伍的多样性
- 批准号:
10563527 - 财政年份:2023
- 资助金额:
$ 130.04万 - 项目类别:
Personalized OSA treatment and effects on AD biomarkers and cognition among blacks
个性化 OSA 治疗及其对黑人 AD 生物标志物和认知的影响
- 批准号:
10687265 - 财政年份:2022
- 资助金额:
$ 130.04万 - 项目类别:
Personalized OSA treatment and effects on AD biomarkers and cognition among blacks
个性化 OSA 治疗及其对黑人 AD 生物标志物和认知的影响
- 批准号:
10525595 - 财政年份:2022
- 资助金额:
$ 130.04万 - 项目类别:
Mechanisms of sleep deficiency and effects on brain injury and neurocognitive functions among older blacks
老年黑人睡眠不足的机制及其对脑损伤和神经认知功能的影响
- 批准号:
10599219 - 财政年份:2020
- 资助金额:
$ 130.04万 - 项目类别:
Mechanisms of sleep deficiency and effects on brain injury and neurocognitive functions among older blacks
老年黑人睡眠不足的机制及其对脑损伤和神经认知功能的影响
- 批准号:
10374040 - 财政年份:2020
- 资助金额:
$ 130.04万 - 项目类别:
Mechanisms of sleep deficiency and effects on brain injury and neurocognitive functions among older blacks
老年黑人睡眠不足的机制及其对脑损伤和神经认知功能的影响
- 批准号:
9976783 - 财政年份:2020
- 资助金额:
$ 130.04万 - 项目类别:
Mechanisms of sleep deficiency and effects on brain injury and neurocognitive functions among older blacks
老年黑人睡眠不足的机制及其对脑损伤和神经认知功能的影响
- 批准号:
10469160 - 财政年份:2020
- 资助金额:
$ 130.04万 - 项目类别:
Determinants of insufficient sleep among blacks and effects on disparities in health outcomes
黑人睡眠不足的决定因素及其对健康结果差异的影响
- 批准号:
10181522 - 财政年份:2019
- 资助金额:
$ 130.04万 - 项目类别:
相似海外基金
Differences in Tumor Biology of Multiple Myeloma in Association with African Ancestry
与非洲血统相关的多发性骨髓瘤肿瘤生物学差异
- 批准号:
10656009 - 财政年份:2023
- 资助金额:
$ 130.04万 - 项目类别:
Identifying placental injury pathways in women of African ancestry with severe preeclampsia
确定患有严重先兆子痫的非洲血统女性的胎盘损伤途径
- 批准号:
10742342 - 财政年份:2023
- 资助金额:
$ 130.04万 - 项目类别:
Community to Molecular Approaches in Early Screening and Diagnosis to Promote Equitable Outcomes Through the Continuum of Care in Cancer Among Populations of African Ancestry
社区采用分子方法进行早期筛查和诊断,通过对非洲裔人群癌症的持续护理来促进公平结果
- 批准号:
10754038 - 财政年份:2023
- 资助金额:
$ 130.04万 - 项目类别:
Genomics of Renal Cancer in Patients of African Ancestry
非洲血统患者肾癌的基因组学
- 批准号:
10648882 - 财政年份:2023
- 资助金额:
$ 130.04万 - 项目类别:
Improving Genetic Diagnosis for African Ancestry Populations
改善非洲血统人群的基因诊断
- 批准号:
10736833 - 财政年份:2023
- 资助金额:
$ 130.04万 - 项目类别:
Genetics of PTSD in African Ancestry Populations: Enhancing discovery by addressing inequality
非洲血统人群 PTSD 的遗传学:通过解决不平等问题加强发现
- 批准号:
10750547 - 财政年份:2023
- 资助金额:
$ 130.04万 - 项目类别:
Microfluidic Droplet Organoids to Decipher the Tumor Heterogeneity in CRC of African Ancestry
微流控液滴类器官破译非洲血统结直肠癌肿瘤异质性
- 批准号:
10355977 - 财政年份:2022
- 资助金额:
$ 130.04万 - 项目类别:
Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations_Supplement
欧洲和非洲血统人群慢性阻塞性肺疾病的多组学风险预测_补充
- 批准号:
10772527 - 财政年份:2022
- 资助金额:
$ 130.04万 - 项目类别:
Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations
欧洲和非洲血统人群慢性阻塞性肺疾病的多组学风险预测
- 批准号:
10445739 - 财政年份:2022
- 资助金额:
$ 130.04万 - 项目类别:
Understanding the contribution of genotype-by-lifestyle interactions to cardiometabolic risk in individuals of east African ancestry
了解基因型与生活方式的相互作用对东非血统个体心脏代谢风险的影响
- 批准号:
10537570 - 财政年份:2022
- 资助金额:
$ 130.04万 - 项目类别: