Core A - Administration
核心 A - 管理
基本信息
- 批准号:10628926
- 负责人:
- 金额:$ 14.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:Advisory CommitteesAge related macular degenerationAgingAlzheimer&aposs DiseaseAnimalsAreaAutomobile DrivingBiochemistryBiologicalCellular biologyCollaborationsDiseaseDisease ProgressionEnsureEtiologyFunctional disorderGoalsHydroxyapatitesIndividualInstitutionLaboratoriesLipidsMedicalMentorsMolecularPathologyPersonsPhysiologyProcessProteinsResearchResearch PersonnelRoleStructureTrainingage relatedcalcificationcalcium phosphateinsightinterdisciplinary approachmeetingsmineralizationmultidisciplinaryprogramsstructural biologysuccessweb site
项目摘要
CORE A SUMMARY
Administrative Core. The overall goal of this Program Project is to elucidate the biological mechanisms of
ectopic calcification and its roles in the onset and etiology of diseases of aging, with particular focus on age-
related macular degeneration (AMD) and Alzheimer’s disease (AD). The major components of ectopic
calcifications are proteins, lipids and mineralized calcium phosphate, especially hydroxyapatite (HAP) and
whitlockite (WHT), but the roles of these components in the calcification process and disease progression are
not known. Four Projects and one technical Core will collaborate to gain a comprehensive mechanistic view of
ectopic calcification in age-related pathologies. Achieving this goal requires an integrated multidisciplinary
approach that combines multi-scale structural biology, biochemistry, cell biology and animal physiology, guided
by experts in these specific areas. The principal role of the Administrative Core is to ensure the success of the
Program as an integrated multidisciplinary and multi-scale investigative effort, and generate a comprehensive
view of calcification in diseases of aging that could not achieved by individual laboratories working alone. This
is essential for gaining comprehensive biomedical insights. To support this goal, the Core will facilitate
interactions among the investigators and provide a strong administrative structure.
核心A摘要
行政核心。本计划项目的总体目标是阐明
异位钙化及其在衰老疾病的发病和病因学中的作用,特别关注年龄-
相关性黄斑变性(AMD)和阿尔茨海默病(AD)。异位妊娠的主要成分
钙化是蛋白质、脂质和矿化的磷酸钙,特别是羟基磷灰石(HAP),
白磷钙石(WHT),但这些成分在钙化过程和疾病进展中的作用是
不知道。四个项目和一个技术核心将合作,以获得全面的机械观点
异位钙化在年龄相关的病理。实现这一目标需要一个综合的多学科
方法,结合多尺度结构生物学,生物化学,细胞生物学和动物生理学,指导
这些特定领域的专家。行政核心的主要作用是确保
计划作为一个综合的多学科和多规模的调查工作,并产生一个全面的
老年疾病中钙化的观点,不能通过单独的实验室工作来实现。这
对于获得全面的生物医学见解至关重要。为支持这一目标,核心将促进
调查人员之间的互动,并提供一个强有力的行政结构。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Francesca M Marassi其他文献
Francesca M Marassi的其他文献
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{{ truncateString('Francesca M Marassi', 18)}}的其他基金
Molecular mechanisms of calcification: roles and opportunities in diseases of aging
钙化的分子机制:在衰老疾病中的作用和机会
- 批准号:
10628925 - 财政年份:2023
- 资助金额:
$ 14.55万 - 项目类别:
Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
10630318 - 财政年份:2016
- 资助金额:
$ 14.55万 - 项目类别:
Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
10207010 - 财政年份:2016
- 资助金额:
$ 14.55万 - 项目类别:
Membrane protein effectors of pathogen interactions with host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
9071833 - 财政年份:2016
- 资助金额:
$ 14.55万 - 项目类别:
Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
10689583 - 财政年份:2016
- 资助金额:
$ 14.55万 - 项目类别:
Membrane protein effectors of pathogen interactions with host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
9276714 - 财政年份:2016
- 资助金额:
$ 14.55万 - 项目类别:
Membrane Protein Effectors of Pathogen Interactions With Host
病原体与宿主相互作用的膜蛋白效应子
- 批准号:
10404547 - 财政年份:2016
- 资助金额:
$ 14.55万 - 项目类别:
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