Core A - Administration

核心 A - 管理

• 批准号: 10628926
• 负责人: Francesca M Marassi
• 金额: $ 14.55万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628926
• 关键词: Advisory Committees; Age related macular degeneration; Aging; Alzheimer' s Disease; Animals; Area; Automobile Driving; Biochemistry; Biological; Cellular biology; Collaborations; Disease; Disease Progression; Ensure; Etiology; Functional disorder; Goals; Hydroxyapatites; Individual; Institution; Laboratories; Lipids; Medical; Mentors; Molecular; Pathology; Persons; Physiology; Process; Proteins; Research; Research Personnel; Role; Structure; Training; age related; calcification; calcium phosphate; insight; interdisciplinary approach; meetings; mineralization; multidisciplinary; programs; structural biology; success; web site

CORE A SUMMARY Administrative Core. The overall goal of this Program Project is to elucidate the biological mechanisms of ectopic calcification and its roles in the onset and etiology of diseases of aging, with particular focus on age- related macular degeneration (AMD) and Alzheimer’s disease (AD). The major components of ectopic calcifications are proteins, lipids and mineralized calcium phosphate, especially hydroxyapatite (HAP) and whitlockite (WHT), but the roles of these components in the calcification process and disease progression are not known. Four Projects and one technical Core will collaborate to gain a comprehensive mechanistic view of ectopic calcification in age-related pathologies. Achieving this goal requires an integrated multidisciplinary approach that combines multi-scale structural biology, biochemistry, cell biology and animal physiology, guided by experts in these specific areas. The principal role of the Administrative Core is to ensure the success of the Program as an integrated multidisciplinary and multi-scale investigative effort, and generate a comprehensive view of calcification in diseases of aging that could not achieved by individual laboratories working alone. This is essential for gaining comprehensive biomedical insights. To support this goal, the Core will facilitate interactions among the investigators and provide a strong administrative structure.

核心一总结