RNA Structure Modeling Using Physics and Sequence Comparison

使用物理和序列比较进行 RNA 结构建模

• 批准号: 10405399
• 负责人: DAVID H. MATHEWS
• 金额: $ 41.01万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10405399
• 关键词: Algorithmic Software; Biology; Biophysics; Collaborations; Communicable Diseases; Communities; Computer software; Data; Disease; Evolution; Foundations; Genetic Diseases; Goals; Health; Human; Methods; Modeling; Pharmacologic Substance; Physics; RNA; RNA Sequences; Role; Structure; Testing; Transcript; Work; base

Abstract: RNA sequences have pervasive roles in biology and RNA molecules are also important pharmaceuticals. Many of these RNA molecules function by use of specific structures, and these structures are therefore conserved across evolution. With the availability of high throughput methods to identify RNA transcripts and probe structure, there is a need to model these structures to get the most information from available data. The goal of the Mathews lab is to develop algorithms and software to model RNA structures, including secondary and tertiary structures. We focus on using biophysical principles, and we are also at the forefront of incorporating additional information in our models, including experimental mapping data and structure conservation. Here, we will build on the foundation of prior work to develop new structure prediction methods. We provide our software freely to the community and we rigorously test our methods with close collaborations with experimentalists.

摘要： RNA序列在生物学中具有广泛的作用，RNA分子也很重要 大药厂这些RNA分子中的许多通过使用特定结构来发挥功能，并且这些 因此，结构在进化过程中是保守的。随着高吞吐量的可用性 鉴定RNA转录物和探针结构的方法，需要对这些结构进行建模 从现有数据中获取最多的信息。马修斯实验室的目标是开发 算法和软件来模拟RNA结构，包括二级和三级结构。 我们专注于使用生物物理学原理，我们也处于将生物物理学原理与生物物理学原理相结合的前沿。 我们模型中的其他信息，包括实验映射数据和结构 节约在此，我们将在先前工作的基础上开发新的结构 预测方法我们向社区免费提供我们的软件，并严格测试我们的 与实验者密切合作。