Early childhood behavioral and neurobiological profiles in the prediction of obesity: The role of self-regulation and the caregiving environment

早期儿童行为和神经生物学特征在肥胖预测中的作用：自我调节和护理环境的作用

• 批准号: 10406237
• 负责人: Anthony Steven Dick
• 金额: $ 67.64万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-20 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10406237
• 关键词: Adolescent; Adult; Affective; Age; Ancillary Study; Area; Arousal; Attention deficit hyperactivity disorder; Autonomic nervous system; Award; Behavioral; Body Composition; Body fat; Body mass index; Brain region; Cardiovascular Diseases; Cessation of life; Child; Child Rearing; Clinical; Cognitive; Data Collection; Development; Diet Habits; Eating; Eating Behavior; Emotional; Energy Intake; Environment; Environmental Risk Factor; Fatty acid glycerol esters; Food; Food Preferences; Functional Magnetic Resonance Imaging; Future; Habits; Health; Hispanic; Home environment; Hyperphagia; Hypertension; Individual; Informal Social Control; Intervention; Latino; Learning; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Morbidity - disease rate; Motivation; Nature; Nervous system structure; Neurobiology; Neuropsychology; Non-Insulin-Dependent Diabetes Mellitus; Nucleus Accumbens; Obesity; Outcome; Overweight; Phenotype; Physical activity; Prevalence; Process; Regulation; Research; Research Personnel; Rewards; Risk; Risk Factors; Role; Sampling; School-Age Population; Short-Term Memory; Stress; Teenagers; Time; Weight; Work; base; behavior measurement; behavioral phenotyping; caregiving; comorbidity; early childhood; emerging adult; emotion regulation; energy balance; ethnic minority population; executive function; experience; feeding; flexibility; high risk population; individual variation; multidisciplinary; neuroimaging; nutrition; obese person; obesity development; obesity in children; obesogenic; peer; physical conditioning; premature; psychosocial; reward processing; sex; social; societal costs

Project Summary While the prevalence rates of pediatric obesity have plateaued in recent years, a staggering 35% of school age children remain classified as overweight or obese. Children from ethnic minority groups are at an even greater risk, with nearly 40% of Latino children so-classified by age 6. The physical and mental health risks and societal costs associated with pediatric obesity are well established. It is thus crucial for research efforts to focus on understanding early behavioral phenotypes that can explain individual variability in children’s regulation of energy balance and subsequent weight trajectory. Researchers have documented self-regulation (SR) and poor executive function (EF) as important mechanisms for understanding the development of pediatric obesity, as well as its shared co-morbidities with other mental health disorders (e.g., Attention-Deficit/Hyperactivity Disorder [ADHD]). Poor executive function (EF), emotion regulation and reactivity (ER), and reward sensitivity (RS) have variously emerged as critical underlying processes in terms of contributing to overeating and food preferences. However, there is a lack of 1) integration of these SR processes when examining weight outcomes, 2) longitudinal studies, which are needed to disentangle whether potential SR deficits are risk factors for the development of obesity or a consequence of it, 3) comprehensive measurement of these SR processes in terms of integrating behavioral measures, neuropsychological, and neurobiological markers, 4) studies examining the predictive association of SR processes as they relate to observed obesogenic mechanisms (e.g., SR of energy intake, healthy- habits) and 5) how environmental factors (e.g., parenting, home environment) can contribute to and moderate the link between SR phenotypes and weight outcomes. Consistent with PAR-18-105, we leverage the ongoing data collection as part of award R01MH112588 (PIs Graziano and Dick), which is measuring young children’s (ages 4 to 6) SR processes (EF, ER, and RS) at a behavioral, neuropsychological, and neurobiological level using MRI. The proposed ancillary study (n = 288) examines how SR phenotypes predict obesogenic mechanisms and subsequent obesity-related trajectories. The proposed sample offers a unique opportunity to examine health outcomes within a typically understudied, yet high-risk population for obesity (i.e., Hispanic/Latino) along with inclusion of a clinical group (i.e., children with ADHD).

项目总结