Advanced Training at the Interface of Engineering and Oral-Craniofacial Sciences

联系PD/PI：KOO，HYUN 口腔疾病和障碍，在颅面复杂的预防性和预防性折磨易受影响的 特别是贫困家庭和医疗或身体受损的人。小说 工程方法，适当利用，可以产生新的范例，揭示疾病机制，新的 减轻疾病的战略，以及负担得起/个性化龋齿治疗的新方法， 牙周病和口腔癌。为了实现这一愿景，学术研究约束牙科科学家必须 熟练掌握工程概念，工程师必须接受口腔和颅面科学方面的教育， 需要;所有人都必须了解复杂的临床和监管环境。为了满足这一迫切需要，我们 提出了一个多学科的培训计划，在宾夕法尼亚大学的牙科医学院（PDM）和 工程与应用科学（SEAS）专注于培训牙科科学家和工程师， 致力于精准口腔健康和医疗创新研究的学术生涯。博士后 学员将采用工程和计算科学前沿的尖端方法， 推进口腔生物膜微生物组、宿主免疫和组织再生领域， 包括人工智能、机器人技术、纳米技术和材料科学， 安全地为患者带来新方法的障碍和要求。学员将参与互动和 量身定制的学术经验与密集的指导研究通过共同指导（一个顾问从每个 学校），并与职业指导委员会（CMC），其中包括至少一名牙科临床医生的互动。 共同导师和CMC成员将从PDM和SEAS的26名教师的计划教师中选出， 多学科和翻译研究的指导的重要记录。培训内容包括：（1） 牙科学员的工程基础和工程学员的口腔和颅面生物学原理， 根据研究项目和学术需求量身定制，（2）临床研究和法规事务，（3） 科学严谨性和可重复性原则，（4）科学写作和（5）专业和 职业发展。学员将参与学术和行业互动，期刊俱乐部，举办研讨会 参加AADR/IADR活动。培训将在F/K奖申请中达到高潮 专注于在牙科工程界面促进口腔健康。申请人在大学池 宾夕法尼亚州是非常强大和多样化，我们预计能够吸引优秀的 候选人此外，通过与ADA，AADR/IADR和少数民族牙科学校的合作，我们将 让我们的候选人多样化我们计划每年招收4名实习生。重要的是，这一努力将成为 PDM和SEAS之间新成立的校际中心，资金共享。所提出的方案， 独特的宾夕法尼亚大学，利用一流的研究和培训环境在一个紧凑的校园， 两所学校的资源通过宾夕法尼亚大学新的创新和精密牙科中心联合起来。 项目摘要/摘要第6页 联系PD/PI：KOO，HYUN 工程方法的进步为推进NIDCR 2030提供了以前无法想象的机会 为所有人提供精准口腔健康的愿景。为了利用这个机会，一个临界质量的交叉培训牙医和 迫切需要从事口腔和颅面研究的工程师。我们将发展这支队伍。

Contact PD/PI: KOO, HYUN Oral diseases and disorders in the craniofacial complex disproportionally and devastatingly afflict susceptible populations, particularly impoverished families and medically or physically compromised persons. Novel engineering approaches, properly leveraged, can yield new paradigms to reveal disease mechanism, new strategies for disease mitigation, and new approaches for affordable/personalized therapies for dental caries, periodontal diseases, and oral cancer. To achieve this vision, academic research bound dentist-scientists must be adept in engineering concepts and engineers must be educated in oral and craniofacial sciences and needs; all must be aware of the complex clinical and regulatory landscapes. To address this urgent need, we propose a multidisciplinary training program in Penn’s School of Dental Medicine (PDM) and School of Engineering & Applied Sciences (SEAS) focused on training dentist-scientists and engineers for academic careers dedicated to research in precision oral health and healthcare innovation. Postdoctoral trainees will adopt cutting-edge approaches at the forefront of engineering and computational sciences to advance the fields of oral biofilm microbiome, host immunity and tissue regeneration, drawing on approaches including artificial intelligence, robotics, nanotechnology, and materials sciences, aware of developmental hurdles and requirements to safely bring new approaches to patients. Trainees will engage in interactive and tailored academic experiences with intensive mentored research via co-mentoring (one advisor from each school), and interaction with a career mentoring committee (CMC) that includes at least one dental clinician. Co-mentors and CMC members will be drawn from the Program Faculty of 26 faculty in PDM and SEAS with significant records of mentorship of multidisciplinary and translational research. Training will include: (1) engineering fundamentals for dental trainees and oral & craniofacial biology principles for engineering trainees, tailored to match their research project and academic needs, (2) clinical research and regulatory affairs, (3) principles of scientific rigor and reproducibility, (4) scientific writing and (5) workshops on professional and career development. Trainees will engage in academic and industry interactions, journal club, give symposia presentations, and participate in AADR/IADR activities. Training will culminate in F/K award applications focused on advancing oral health at the dental-engineering interface. The applicant pool at the University of Pennsylvania is exceptionally strong and diverse, and we anticipate being able to attract outstanding candidates. Furthermore, via partnerships with ADA, AADR/IADR and minority-serving dental schools, we will diversify our candidate pool. We plan to enroll 4 trainees per year. Importantly, this effort will be an element of a newly formed inter-school center between PDM and SEAS with shared funding. The proposed program, unique to Penn, leverages a superb research and training environment within a compact campus where resources for both schools are united through Penn’s new Center for Innovation and Precision Dentistry. Project Summary/Abstract Page 6 Contact PD/PI: KOO, HYUN Advances in engineering approaches offer previously unimagined opportunities to advance the NIDCR 2030 vision of precision oral health for all. To harness this opportunity, a critical mass of cross-trained dentists and engineers engaged in oral and craniofacial research are urgently needed. We will develop this workforce.