My ESSENCE - Mindfulness to Reduce Stress, Improve SIeep, and Reduce Cardiovascular Risk in African-Americans with Type 2 Diabetes

项目摘要 在美国，非裔美国人患心血管疾病(CVD)的比例不成比例。非洲裔美国人 患有2型糖尿病(T2 DM)的人患心血管疾病的风险是非西班牙裔白人的两倍。睡眠质量下降 而更大的慢性心理压力可能会导致这种额外的风险。因此，非洲- 在那些患有糖尿病和心血管疾病风险较高的人中，美国人的血糖控制较差。一件有希望的事 改善非裔美国人心血管疾病风险的方法是正念冥想(MM)。MM可以潜在地 通过注意力控制、情绪调节和自我意识来降低心血管风险。整体而言 这笔K01培训补助金的目的是让Alana Biggers博士获得研究培训并发展所需的技能 成为一名独立的调查员，并使用这些技能来适应和评估一名成熟的MM 课程(基于正念的失眠治疗，或MBT-I)。具体目标是：(1)适应和完善 针对患有2型糖尿病和短信的非裔美国人的MBT-I课程；(2)开展8- 每周，对68名患有T2 DM的非洲裔美国人进行调整后的课程的试点随机对照试验； (3)探讨干预对心脏代谢危险因素(血压、糖化程度)的影响 和炎症生物标志物(C-反应蛋白、白介素6和肿瘤 肿瘤坏死因子α)。主要结果将包括在基线时评估的睡眠质量和感觉到的压力， 还有16周。建议的研究设计包括先导研究，利用混合方法研究，以及 涉及主要数据收集和分析。这笔K01培训补助金将为比格斯博士提供职业生涯- 开展活动，进一步发展定量和定性方法方面的技能和知识库， 少数群体中的健康差距研究和移动健康(MHealth)/行为健康战略。 在跨学科指导团队和机构支持的指导下，比格斯博士将获得 必要的帮助和培训，以实现她成为独立人士的长期职业目标 在健康差异、混合方法和移动健康行为研究方面具有专业知识的研究人员。

Project Summary African-Americans have disproportionate rates of cardiovascular disease (CVD) in the US. African-Americans with type 2 diabetes (T2DM) have twice the risk than non-Hispanic whites for developing CVD. Poorer sleep and greater chronic psychological stress may contribute to this additional risk. Consequently, African- Americans have worse glycemic control among those with diabetes and higher CVD risk. One promising approach to improving CVD risk in African-Americans is mindfulness meditation (MM). MM can potentially reduce cardiovascular risk through attention control, emotional regulation, and self-awareness. The overall purpose of this K01 training grant is for Dr. Alana Biggers to obtain research training and develop skills needed to become an independent investigator, and use those skills to adapt and evaluate an established MM curriculum (Mindfulness Based Therapy for Insomnia, or MBT-I). The specific aims are to: (1) adapt and refine the MBT-I curriculum for African-Americans with T2DM and incorporate text messaging; (2) conduct an 8- week, pilot randomized, controlled trial of the adapted curriculum with 68 African-Americans with T2DM; and (3) explore the impact of the intervention on cardiometabolic risk factors (blood pressure, glycosylated hemoglobin, and lipid profile) and inflammatory biomarkers (C-reactive protein, interleukin-6, and tumor necrosis factor α). Primary outcomes will include sleep quality and perceived stress evaluated at baseline, 8, and 16 weeks. The proposed research design consists of a pilot study, utilizes mixed-methods research, and involves both primary data collection and analysis. This K01 training grant will provide Dr. Biggers career- building activities to further develop skills and a knowledge base in quantitative and qualitative methodology, health disparities research, and mobile health (mHealth)/behavioral health strategies in minority populations. With the guidance of an interdisciplinary mentorship team and institutional support, Dr. Biggers will receive the necessary assistance and training to work toward her long-term career goal of being an independent researcher with expertise in health disparities, mixed-methods, and mHealth behavioral research.