My ESSENCE - Mindfulness to Reduce Stress, Improve SIeep, and Reduce Cardiovascular Risk in African-Americans with Type 2 Diabetes

我的精髓 - 正念可以减轻患有 2 型糖尿病的非洲裔美国人的压力、改善睡眠并降低心血管风险

• 批准号: 10349479
• 负责人: Alana Biggers
• 金额: $ 14.13万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10349479
• 关键词: Address; Adult; African American; African American population; American; Attention; Behavior; Behavioral Research; Biological Markers; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Caring; Chronic; Chronic Disease; Chronic Insomnia; Chronic stress; Cross-Sectional Studies; Data Analyses; Data Collection; Diabetes Mellitus; Educational Curriculum; Evaluation; Glycosylated Hemoglobin; Goals; Grant; Health Disparities Research; Home; Hyperactivity; Inflammation; Inflammatory; Interleukin-6; Intervention; Intervention Studies; Life Style; Lipids; Longitudinal Studies; Mediating; Mentorship; Metabolic dysfunction; Methodology; Methods; Mindfulness Training; Minority Groups; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Participant; Persons; Physicians; Pilot Projects; Psychological Stress; Randomized Controlled Trials; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Training; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Self Perception; Sleep; Sleep Disorders; Sleeplessness; Socioeconomic Status; Stress; TNF gene; Text Messaging; Training; Work; attentional control; behavioral health; biological adaptation to stress; cardiometabolic risk; cardiovascular disorder risk; cardiovascular effects; cardiovascular risk factor; career; design; diabetes control; diabetes self-management; emotion regulation; factor A; follow-up; glycemic control; group intervention; health disparity; high risk; hypothalamic pituitary axis; improved; knowledge base; mHealth; mindfulness; mindfulness meditation; mortality; perceived stress; poor sleep; primary outcome; programs; skills; sleep health; sleep quality; sleep regulation; stress management; stress reduction; stressor

Project Summary African-Americans have disproportionate rates of cardiovascular disease (CVD) in the US. African-Americans with type 2 diabetes (T2DM) have twice the risk than non-Hispanic whites for developing CVD. Poorer sleep and greater chronic psychological stress may contribute to this additional risk. Consequently, African- Americans have worse glycemic control among those with diabetes and higher CVD risk. One promising approach to improving CVD risk in African-Americans is mindfulness meditation (MM). MM can potentially reduce cardiovascular risk through attention control, emotional regulation, and self-awareness. The overall purpose of this K01 training grant is for Dr. Alana Biggers to obtain research training and develop skills needed to become an independent investigator, and use those skills to adapt and evaluate an established MM curriculum (Mindfulness Based Therapy for Insomnia, or MBT-I). The specific aims are to: (1) adapt and refine the MBT-I curriculum for African-Americans with T2DM and incorporate text messaging; (2) conduct an 8- week, pilot randomized, controlled trial of the adapted curriculum with 68 African-Americans with T2DM; and (3) explore the impact of the intervention on cardiometabolic risk factors (blood pressure, glycosylated hemoglobin, and lipid profile) and inflammatory biomarkers (C-reactive protein, interleukin-6, and tumor necrosis factor α). Primary outcomes will include sleep quality and perceived stress evaluated at baseline, 8, and 16 weeks. The proposed research design consists of a pilot study, utilizes mixed-methods research, and involves both primary data collection and analysis. This K01 training grant will provide Dr. Biggers career- building activities to further develop skills and a knowledge base in quantitative and qualitative methodology, health disparities research, and mobile health (mHealth)/behavioral health strategies in minority populations. With the guidance of an interdisciplinary mentorship team and institutional support, Dr. Biggers will receive the necessary assistance and training to work toward her long-term career goal of being an independent researcher with expertise in health disparities, mixed-methods, and mHealth behavioral research.

项目概要 在美国，非裔美国人心血管疾病 (CVD) 的发病率不成比例。非裔美国人 2 型糖尿病 (T2DM) 患者患 CVD 的风险是非西班牙裔白人的两倍。睡眠质量较差 更大的慢性心理压力可能会导致这种额外的风险。因此，非洲—— 美国人的糖尿病患者血糖控制较差，心血管疾病风险较高。一位有前途的 降低非裔美国人 CVD 风险的方法是正念冥想 (MM)。 MM可以有潜力 通过注意力控制、情绪调节和自我意识来降低心血管风险。整体 K01 培训补助金的目的是让 Alana Biggers 博士获得研究培训并发展所需的技能 成为一名独立调查员，并利用这些技能来适应和评估已建立的 MM 课程（基于正念的失眠疗法，或 MBT-I）。具体目标是：（一）调整和完善 针对患有 T2DM 的非洲裔美国人的 MBT-I 课程并纳入短信； (2) 进行 8- 周，对 68 名患有 T2DM 的非洲裔美国人进行改编课程的随机对照试验；和 （3）探讨干预措施对心脏代谢危险因素（血压、糖化水平）的影响 血红蛋白和血脂谱）和炎症生物标志物（C 反应蛋白、白细胞介素 6 和肿瘤 坏死因子α）。主要结果将包括基线评估的睡眠质量和感知压力，8， 和 16 周。拟议的研究设计包括一项试点研究，利用混合方法研究，以及 涉及原始数据收集和分析。这笔 K01 培训补助金将为 Biggers 博士提供职业生涯- 开展活动以进一步发展定量和定性方法方面的技能和知识基础， 健康差异研究以及少数群体的移动健康（mHealth）/行为健康策略。 在跨学科导师团队的指导和机构支持下，比格斯博士将获得 必要的帮助和培训，以实现她成为独立的长期职业目标 具有健康差异、混合方法和移动健康行为研究方面专业知识的研究人员。