My ESSENCE - Mindfulness to Reduce Stress, Improve SIeep, and Reduce Cardiovascular Risk in African-Americans with Type 2 Diabetes

我的精髓 - 正念可以减轻患有 2 型糖尿病的非洲裔美国人的压力、改善睡眠并降低心血管风险

• 批准号: 10557847
• 负责人: Alana Biggers
• 金额: $ 14.01万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557847
• 关键词: Address; Adult; African American; African American population; American; Attention; Behavior; Behavioral Research; Biological Markers; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Caring; Chronic; Chronic Disease; Chronic Insomnia; Chronic stress; Data Analyses; Data Collection; Diabetes Mellitus; Disease; Educational Curriculum; Evaluation; Glycosylated Hemoglobin; Goals; Grant; Health Disparities Research; Home; Hyperactivity; Inflammation; Inflammatory; Institution; Interleukin-6; Intervention; Intervention Studies; Life Style; Lipids; Longitudinal Studies; Mediating; Mentorship; Metabolic dysfunction; Methodology; Methods; Mindfulness Training; Minority Groups; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Participant; Persons; Physicians; Pilot Projects; Population; Psychological Stress; Randomized, Controlled Trials; Recommendation; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Training; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Self Perception; Sleep; Sleep Disorders; Sleeplessness; Socioeconomic Status; Stress; TNF gene; Text Messaging; Training; Work; attentional control; behavioral health; biological adaptation to stress; cardiometabolic risk; cardiovascular disorder risk; cardiovascular effects; cardiovascular risk factor; career; comparison control; design; diabetes control; diabetes self-management; emotion regulation; follow-up; glycemic control; group intervention; health disparity; high risk; hypothalamic pituitary axis; improved; improvement on sleep; knowledge base; mHealth; mindfulness; mindfulness meditation; mortality; perceived stress; poor sleep; primary outcome; programs; skills; sleep health; sleep quality; sleep regulation; stress management; stress reduction; stressor

Project Summary African-Americans have disproportionate rates of cardiovascular disease (CVD) in the US. African-Americans with type 2 diabetes (T2DM) have twice the risk than non-Hispanic whites for developing CVD. Poorer sleep and greater chronic psychological stress may contribute to this additional risk. Consequently, African- Americans have worse glycemic control among those with diabetes and higher CVD risk. One promising approach to improving CVD risk in African-Americans is mindfulness meditation (MM). MM can potentially reduce cardiovascular risk through attention control, emotional regulation, and self-awareness. The overall purpose of this K01 training grant is for Dr. Alana Biggers to obtain research training and develop skills needed to become an independent investigator, and use those skills to adapt and evaluate an established MM curriculum (Mindfulness Based Therapy for Insomnia, or MBT-I). The specific aims are to: (1) adapt and refine the MBT-I curriculum for African-Americans with T2DM and incorporate text messaging; (2) conduct an 8- week, pilot randomized, controlled trial of the adapted curriculum with 68 African-Americans with T2DM; and (3) explore the impact of the intervention on cardiometabolic risk factors (blood pressure, glycosylated hemoglobin, and lipid profile) and inflammatory biomarkers (C-reactive protein, interleukin-6, and tumor necrosis factor α). Primary outcomes will include sleep quality and perceived stress evaluated at baseline, 8, and 16 weeks. The proposed research design consists of a pilot study, utilizes mixed-methods research, and involves both primary data collection and analysis. This K01 training grant will provide Dr. Biggers career- building activities to further develop skills and a knowledge base in quantitative and qualitative methodology, health disparities research, and mobile health (mHealth)/behavioral health strategies in minority populations. With the guidance of an interdisciplinary mentorship team and institutional support, Dr. Biggers will receive the necessary assistance and training to work toward her long-term career goal of being an independent researcher with expertise in health disparities, mixed-methods, and mHealth behavioral research.

项目总结