FEBio - Finite Elements for Biomechanics and Biophysics

摘要 有限元分析已经成为生物医学科学研究和发现中不可或缺的工具。 从历史上看，缺乏为外地需求量身定做的开放软件环境阻碍了 研究进展、研究成果的传播以及模型和成果的分享。为了解决这些问题，我们 开发了FEBio软件，这是一个专门为生物力学和 生物物理学。FEBio使用混合理论来解释生物组织和 流体，统一不可逆热力学、固体力学、流体力学、质量等经典领域 运输、化学反应和电动力学。此外，我们还开发了一种综合开发 环境，称为FEBio Studio，它为构建、运行和分析提供了图形用户界面 FEBio模型。在这一行政补充申请中，我们提出了两个目标：1)提高可持续性 以及FEBio和FEBio Studio的可重用性；2)调整FEBio解算器以促进云计算。这些新的 能力将扩大在FEBio和FEBio Studio开发中使用最佳软件做法，以及 利用FEBio提高云计算的可及性，促进科学进步。

SUMMARY Finite element analysis has become an indispensable tool for research and discovery in the biomedical sciences. Historically, the lack of an open software environment that was tailored to the needs of the field hampered research progress, dissemination of research and sharing of models and results. To address these issues, we developed the FEBio software, a FE framework designed specifically for analysis in biomechanics and biophysics. FEBio employs mixture theory to account for the multi-constituent nature of biological tissues and fluids, unifying the classical fields of irreversible thermodynamics, solid mechanics, fluid mechanics, mass transport, chemical reactions and electrokinetics. In addition, we developed an integrated development environment, called FEBio Studio, which offers a graphical user interface for building, running, and analyzing FEBio models. In this administrative supplement application, we propose two aims: 1) Improve the sustainability and reusability of FEBio and FEBio Studio; 2) Adapt the FEBio solver to facilitate cloud computing. These new capabilities will expand the use of best software practices in the development of FEBio and FEBio Studio, and improve the accessibility of cloud computing with FEBio, facilitating scientific advancement.