North Carolina Translational and Clinical Science Institute (NC TraCS)

北卡罗来纳州转化与临床科学研究所 (NC TraCS)

• 批准号: 10407956
• 负责人: John Bernard Buse
• 金额: $ 994.56万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2023-04-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407956
• 关键词: Address; Advocacy; Advocate; Attention; Basic Science; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Complex; Data; Discipline; Disclosure; Disease Management; Environment; Faculty; Fostering; Funding; Goals; Grant; Growth; Health; Health Personnel; Healthcare; Healthcare Systems; Informatics; Infrastructure; Institutes; Institution; Interdisciplinary Study; International; Investments; Lead; Leadership; Legal patent; Lesbian Gay Bisexual Transgender; Licensing; Longevity; Manuscripts; Mental Health; Mentors; Methodology; Methods; Mission; Modeling; National Center for Advancing Translational Sciences; North Carolina; Obesity; Outcome; Participant; Pathway interactions; Patients; Phase; Policies; Population; Populations at Risk; Positioning Attribute; Process; Provider; Public Health; Publications; Publishing; Reproducibility; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Role; Rural Population; Science; Sea; Services; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Substance abuse problem; Techniques; Testing; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Work; Workforce Development; career development; community intervention; community organizations; design; disability; ethnic minority population; evidence base; health care availability; human disease; income disparities; informatics tool; innovation; invention; literacy; low socioeconomic status; member; multi-site trial; next generation; novel; novel strategies; programs; racial minority; recruit; research study; rural counties; skills; success; tool; translational impact; translational pipeline; translational scientist

Contact PD/PI: Buse, John B Overall Abstract Since our inception in 2008, the UNC CTSA affiliate, the North Carolina Translational and Clinical Sciences Institute (TraCS) has transformed clinical and translational science at UNC through interdisciplinary research, training, collaboration with partners and stakeholders, and strong engagement across the CTSA consortium. We have built a dynamic regional network of universities, research institutes, health care providers, and >130 community organizations across our state. In the coming funding period, we propose to add NC State University in addition to RTI International and NC A&T University as full partners in our CTSA hub. Our research infrastructure has engaged 3,234 registered members, resolved 11,147 research service requests, trained 63 faculty in our KL2 program, and supported 705 pilot grants, resulting in >$170M in external research funding, and >600 published manuscripts that have been cited >21,000 times. TraCS developed Join the Conquest, an online engagement tool to increase participation in clinical trials, that includes over 6,000 registered participants and over 200 unique research studies. The TraCS 4D Strategic Initiative and KickStart Program have facilitated 141 invention disclosures, 99 patents, 40 licenses, $57M in SBIR/STTR grants, and the creation of 68 new companies. Over the next five years, we will translate the best science from UNC and across the CTSA consortium into creative, effective, and accessible clinical and community interventions, addressing the public health problems of our state and advancing national CTSA goals by completing our Overall Aims. Aim 1 Workforce Development: Develop and support a skilled and diverse clinical and translational research workforce to advance translational innovations and address healthcare priorities. Aim 2 Collaboration and Engagement: Engage diverse stakeholders as active partners in translational research, and promote innovative approaches to team science. Aim 3 Integration: Integrate translational research across the research continuum, disciplines, populations, and throughout the lifespan; Aim 4 Methods/Processes: Develop and disseminate innovative methods and approaches to address scientific and operational barriers to translating scientific findings. Aim 5 Informatics: Incorporate cutting-edge informatics tools and methodologies in every aspect of translational research. We believe that we have made exceptional strides in engaging our partners and our community in our activities and are well positioned to advance our mission as a public university CTSA. Going forward, we will further engage our stakeholders in the research process; train the next generation of translational researchers to flourish within interdisciplinary teams; effectively synergize clinical research with health care to identify unmet needs and implement solutions, particularly for populations at risk for poor health outcomes; and rapidly disseminate our findings to our patients, our community partners, and the CTSA Consortium. Project Summary/Abstract Page 176 Contact PD/PI: Buse, John B

联系人 PD/PI：Buse, John B 总体摘要 自 2008 年成立以来，北卡罗来纳大学 CTSA 附属机构北卡罗来纳州翻译和 临床科学研究所 (TraCS) 改变了北卡罗来纳大学的临床和转化科学 通过跨学科研究、培训、与合作伙伴和利益相关者的合作，以及 CTSA 联盟的大力参与。我们建立了一个充满活力的区域网络 大学、研究机构、医疗保健提供者和超过 130 个社区组织 整个州。在接下来的资助期内，我们建议将北卡罗来纳州立大学添加到 此外，RTI International 和 NC A&T 大学也是我们 CTSA 中心的正式合作伙伴。我们的 研究基础设施已吸引 3,234 名注册会员，解决了 11,147 项研究 服务请求，在我们的 KL2 项目中培训了 63 名教员，并支持了 705 项试点拨款， 导致超过 1.7 亿美元的外部研究经费，以及超过 600 篇已发表的手稿 被引用 >21,000 次。 TraCS 开发了 Join the Conquest，一种在线参与工具 增加临床试验的参与度，其中包括超过 6,000 名注册参与者 200 项独特的研究。 TraCS 4D 战略计划和 KickStart 计划已 促进了 141 项发明披露、99 项专利、40 项许可、5700 万美元的 SBIR/STTR 拨款，以及 创建68家新公司。 在接下来的五年里，我们将翻译北卡罗来纳大学和整个 CTSA 的最佳科学成果 联盟致力于创造性、有效且易于使用的临床和社区干预措施， 解决我们州的公共卫生问题并推进国家 CTSA 目标 完成我们的总体目标。目标 1 劳动力发展：培养和支持熟练技术人员 以及多元化的临床和转化研究人员来推动转化创新 并解决医疗保健优先事项。目标 2 协作和参与：多元化参与 利益相关者作为转化研究的积极合作伙伴，并促进创新方法 团队科学。目标 3 整合：将转化研究整合到整个研究中 连续体、学科、人群和整个生命周期；目标 4 方法/过程： 开发和传播创新方法和途径来解决科学和技术问题 翻译科学发现的操作障碍。目标 5 信息学：融合尖端技术 转化研究各个方面的信息学工具和方法。 我们相信，我们在吸引合作伙伴和社区方面取得了非凡的进步 积极参与我们的活动，并有能力推进我们作为公立大学 CTSA 的使命。 展望未来，我们将进一步让利益相关者参与研究过程；训练下一个 一代转化研究人员在跨学科团队中蓬勃发展；有效地 将临床研究与医疗保健相结合，以确定未满足的需求并实施解决方案， 特别是对于面临健康状况不佳风险的人群；并迅速传播我们的发现 致我们的患者、社区合作伙伴和 CTSA 联盟。 项目总结/摘要第 176 页 联系人 PD/PI：Buse, John B