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CTSA Diversity Supplement - Vielot - Effectiveness of Recombinant Herpes Zoster Vaccine in Older U.S. Adults

CTSA 多样性补充 - Vielot - 重组带状疱疹疫苗对美国老年人的有效性

基本信息

批准号：
10294412
负责人：
John Bernard Buse
金额：
$ 17万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10294412
关键词：
Academia Address Adjuvant Adolescence Adolescent Adrenal Cortex Hormones Adult Advisory Committees Age Age-Years Agreement Algorithms Anatomy Applications Grants Area Autoimmune Diseases Autologous Award Biological Biological Products Black race Blindness COVID-19 pandemic COVID-19 vaccine Cardiovascular Diseases Caring Case Study Centers for Disease Control and Prevention (U.S.)Characteristics Chemicals Chickenpox Classification Clinical Clinical Management Clinical Medicine Clinical Research Clinical Sciences Clinical Trials Code Cohort Studies Collaborations Communicable Diseases Communication Comparative Effectiveness Research Consult Consultations Cox Models Current Procedural Terminology Codes Data Data Analyses Data Collection Data Science Data Set Data Sources Databases Detection Development Development Plans Diabetes Mellitus Diagnosis Discipline Disease Disease-Modifying Second-Line Drugs Disseminated Malignant Neoplasm Doctor of Philosophy Dose Drug Industry Drug Prescriptions Educational process of instructing Educational workshop Effectiveness Elderly Electronic Health Record Emergency Situation End stage renal failure Enrollment Epidemiologic Methods Epidemiologist Epidemiology Equipment Ethics Committees Ethnic Origin Evaluation Event Exercise Faculty Family Practice Fee-for-Service Plans Feedback Funding Future Geographic Locations Geography Goals Gold Government Grant HIV Health Health Care Seeking Behavior Health Personnel Health Policy Health Services Health Services Research Health Status Health system Healthcare Healthcare Systems Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Herpes Zoster Ophthalmicus Herpes zoster disease Hospitals Hour ICD-9 Immunization Immunocompetence Immunocompetent Immunocompromised Host Immunosuppression Immunosuppressive Agents Incidence Individual Industry Infant Infection Informatics Inpatients Institutes Institutional Review Boards Insurance Claim Review Interdisciplinary Study International International Classification of Diseases Intervention K-Series Research Career Programs Lead Leadership Learning Licensure Life Cycle Stages Light Link Longevity Longitudinal Studies Malignant Neoplasms Manuscripts Maps Measures Medical Medicare Medicare Part A Medicare claim Medicine Mentors Mentorship Methodology Methods Modeling Modification Monitor Multi-Institutional Clinical Trial North Carolina Obesity Observation in research Older Population Opioid Oral Organ Transplantation Outcome Outcomes Research Outpatients Pain Parents Participant Patients Pattern Peer Group Peer Review Perinatal Infection Persistent pain Persons Pharmaceutical Preparations Pharmacoepidemiology Pharmacologic Substance Pharmacy facility Policies Population Population Heterogeneity Positioning Attribute Postdoctoral Fellow Postherpetic neuralgia Predictive Value Pregnant Women Preventive healthcare Primary Health Care Procedures Process Program Development Protocols documentation Proxy Public Health Public Policy Publications Race Randomized Reading Recombinants Recommendation Records Reference Standards Regulation Research Research Design Research Institute Research Methodology Research Personnel Research Project Grants Research Training Resources Respiratory syncytial virus Risk Risk Management Role Rotation Safety Safety Management Sampling Science Scientist Secure Series Services Societies Solid Specialist Statistical Data Interpretation Statistical Methods Streptococcus Group B Structure Students Study Section Subgroup Subunit Vaccines Syndrome TNFSF15 gene Testing Therapeutic Time TimeLine Trainers Training Training Translating Translational Research Translations Transplant Recipients Underrepresented Populations United States United States Centers for Medicare and Medicaid Services United States Food and Drug Administration United States National Institutes of Health Universities Update Use Effectiveness Vaccinated Vaccination Vaccine Clinical Trial Vaccines Validation Visit Vulnerable Populations Woman Work Workforce Development Writing Zoster Vaccine age group base beneficiary career career development causal model chemotherapy clinical Diagnosis cohort community intervention community organizations comorbidity comparative effectiveness comparison group congenital immunodeficiency data access data dissemination data warehouse disability doctoral student effectiveness evaluation effectiveness study efficacy trial epidemiology study evidence base experience faculty mentor faculty support follow-up frailty graduate student hazard health care service health care service utilization health data health disparity high risk population human old age (65+)immunogenic immunogenicity improved indexing infancy informatics tool innovation inpatient service insight insurance claims interest leukemia/lymphoma low income country medical schools medication safety meetings member neonatal infection novel novel vaccines outpatient programs pandemic disease patient health information patient subsets peer policy implication power analysis prevent primary outcome professor programs racial and ethnic reactivation from latency research and development research study responsible research conduct risk minimization secondary outcome sex skills study population symposium training opportunity vaccination outcome vaccine acceptance vaccine access vaccine development vaccine effectiveness vaccine efficacy vaccine evaluation vaccine safety vaccine trial virtual working group

项目摘要

Abstract/Summary of Parent Award Since inception in 2008, the UNC CTSA affiliate, the North Carolina Translational and Clinical Sciences Institute (TraCS) has transformed clinical and translational science at UNC through interdisciplinary research, training, collaboration with partners and stakeholders, and strong engagement across the CTSA consortium. We have built a dynamic regional network of universities, research institutes, health care providers, and >130 community organizations across our state. In the current funding period, we have added NC State University to RTI International and NC A&T University as full partners in our CTSA hub. In the funding period 2013-2023, our goal is to translate the best science from UNC and across the CTSA consortium into creative, effective, and accessible clinical and community interventions, addressing the public health problems of our state and advancing national CTSA goals. We accomplish through 5 aims: Aim 1. Workforce Development: Develop and support a skilled and diverse clinical and translational research workforce to advance translational innovations and address healthcare priorities. Aim 2. Collaboration and Engagement: Engage diverse stakeholders as active partners in translational research, and promote innovative approaches to team science. Aim 3. Integration: Integrate translational research across the research continuum, disciplines, populations, and throughout the lifespan. Aim 4. Methods/Processes: Develop and disseminate innovative methods and approaches to address scientific and operational barriers to translating scientific findings. Aim 5. Informatics: Incorporate cutting-edge informatics tools and methodologies in every aspect of translational research. This diversity supplement application by Nadja Vielot, PhD will use real-world Medicare claims data to study the post-licensure experience in the United States with recombinant herpes zoster vaccine (RZV). The aims of the proposal are to: 1) Estimate RZV effectiveness against herpes zoster, post-herpetic neuralgia (PHN) and herpes zoster ophthalmicus (HZO) in adults ages >65, and 2) Estimate the effectiveness of RZV in individuals with altered immunocompetence. Dr. Vielot will utilize the following CTSA Program resources for the research and training plan: Comparative Effectiveness Research: This Service will facilitate the process of securing Medicare data and oversight of the analyses. Informatics and Data Science: This Service will be used as part of Aim 3 to obtain data from the Carolina Data Warehouse for Health (CDW-H) and for assistance in linking CDW-H data to Medicare claims data. Regulatory Service: Dr. Vielot will use this service for guidance on completing the appropriate IRB and data use agreements required for the project. Workforce Development Program: Dr. Vielot will participate in the following WD training opportunities: TraCS Professional Development Seminar, R Writing Group, Mentor Training, and training in requirements for rigor. KL2 Program: Dr. Vielot will participate in the K Seminar; a seminar comprised of TraCS-funded KL2 awardees and selected individual K awardees. During this interdisciplinary seminar, she will hone her communication skills, receive feedback on work in progress including input from clinicians about the potential clinical and policy implications of her work, identify collaborators for future work, practice peer review skills, and network with a peer group of interdisciplinary scientists. TL1 Program: The TraCS TL1 Program consists of 3 tracks, 1 of which supports postdocs who wish to translate research results into health systems and policy. Dr. Vielot will participate in the TL1 "Tales of Translation" series which features experts from academia, industry and government discussing pivotal points in their careers, important research projects, and their views on opportunities and challenges when translating research results into policy. In addition, Dr. Vielot will attend either the virtual or in-person annual Translational Science meeting.

摘要/家长奖总结