North Carolina Translational and Clinical Science Institute (NC TraCS)

北卡罗来纳州转化与临床科学研究所 (NC TraCS)

• 批准号: 10585423
• 负责人: John Bernard Buse
• 金额: $ 21.83万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10585423
• 关键词: Address; Advocacy; Advocate; Attention; Basic Science; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Complex; Data; Discipline; Disclosure; Disease Management; Environment; Faculty; Fostering; Funding; Goals; Grant; Growth; Health; Health Personnel; Healthcare; Healthcare Systems; Informatics; Infrastructure; Institutes; Institution; Interdisciplinary Study; International; Investments; Lead; Leadership; Legal patent; Lesbian Gay Bisexual Transgender; Licensing; Longevity; Manuscripts; Mental Health; Mentors; Methodology; Methods; Mission; Modeling; National Center for Advancing Translational Sciences; North Carolina; Obesity; Outcome; Participant; Pathway interactions; Patients; Phase; Policies; Population; Populations at Risk; Positioning Attribute; Process; Provider; Public Health; Publications; Publishing; Reproducibility; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Role; Rural Population; Science; Sea; Services; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Substance abuse problem; Techniques; Testing; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Work; Workforce Development; career development; community intervention; community organizations; design; disability; ethnic minority population; evidence base; health care availability; human disease; income disparities; informatics tool; innovation; invention; literacy; low socioeconomic status; member; multi-site trial; next generation; novel; novel strategies; programs; racial minority; recruit; research study; rural counties; skills; success; tool; translational impact; translational pipeline; translational scientist

Contact PD/PI: Buse, John B Overall Abstract Since our inception in 2008, the UNC CTSA affiliate, the North Carolina Translational and Clinical Sciences Institute (TraCS) has transformed clinical and translational science at UNC through interdisciplinary research, training, collaboration with partners and stakeholders, and strong engagement across the CTSA consortium. We have built a dynamic regional network of universities, research institutes, health care providers, and >130 community organizations across our state. In the coming funding period, we propose to add NC State University in addition to RTI International and NC A&T University as full partners in our CTSA hub. Our research infrastructure has engaged 3,234 registered members, resolved 11,147 research service requests, trained 63 faculty in our KL2 program, and supported 705 pilot grants, resulting in >$170M in external research funding, and >600 published manuscripts that have been cited >21,000 times. TraCS developed Join the Conquest, an online engagement tool to increase participation in clinical trials, that includes over 6,000 registered participants and over 200 unique research studies. The TraCS 4D Strategic Initiative and KickStart Program have facilitated 141 invention disclosures, 99 patents, 40 licenses, $57M in SBIR/STTR grants, and the creation of 68 new companies. Over the next five years, we will translate the best science from UNC and across the CTSA consortium into creative, effective, and accessible clinical and community interventions, addressing the public health problems of our state and advancing national CTSA goals by completing our Overall Aims. Aim 1 Workforce Development: Develop and support a skilled and diverse clinical and translational research workforce to advance translational innovations and address healthcare priorities. Aim 2 Collaboration and Engagement: Engage diverse stakeholders as active partners in translational research, and promote innovative approaches to team science. Aim 3 Integration: Integrate translational research across the research continuum, disciplines, populations, and throughout the lifespan; Aim 4 Methods/Processes: Develop and disseminate innovative methods and approaches to address scientific and operational barriers to translating scientific findings. Aim 5 Informatics: Incorporate cutting-edge informatics tools and methodologies in every aspect of translational research. We believe that we have made exceptional strides in engaging our partners and our community in our activities and are well positioned to advance our mission as a public university CTSA. Going forward, we will further engage our stakeholders in the research process; train the next generation of translational researchers to flourish within interdisciplinary teams; effectively synergize clinical research with health care to identify unmet needs and implement solutions, particularly for populations at risk for poor health outcomes; and rapidly disseminate our findings to our patients, our community partners, and the CTSA Consortium. Project Summary/Abstract Page 176 Contact PD/PI: Buse, John B

联系PD/PI：Buse、John B 总体摘要 自2008年成立以来，我们的分支机构，北卡罗来纳州翻译和 临床科学研究所（TraCS）已经改变了临床和转化科学在伦敦大学 通过跨学科研究、培训、与合作伙伴和利益攸关方的合作， CTSA联盟的强大参与。我们建立了一个充满活力的区域网络， 大学、研究机构、医疗保健提供者和超过130个社区组织 穿越我们的州在下一个资助期内，我们建议增设北卡罗来纳州立大学， 除了RTI国际和NC A&T大学作为我们的CTSA中心的全面合作伙伴。我们 科研基础设施已吸纳注册会员3,234人，解决科研课题11,147个 服务要求，培训了63名教师在我们的KL 2计划，并支持705试点赠款， 导致超过1.7亿美元的外部研究资金，以及超过600篇已发表的手稿， 被引用超过21,000次。TraCS开发了Join the Conquest，一个在线参与工具， 增加参与临床试验，包括6，000多名注册参与者和 200个独特的研究。TraCS 4D战略计划和KickStart计划 促成了141项发明披露，99项专利，40项许可证，5700万美元的SBIR/STTR赠款， 成立68家新公司。 在接下来的五年里，我们将把最好的科学从美国和整个CTSA翻译出来。 联合开展创造性、有效且易于获得的临床和社区干预措施， 解决我们国家的公共卫生问题，推进国家CTSA目标， 完成我们的总体目标。目标1劳动力发展：发展和支持一个熟练的 以及多样化的临床和转化研究队伍，以推进转化创新 解决医疗保健优先事项。目标2协作和参与：参与多元化 利益相关者作为转化研究的积极合作伙伴，并促进创新方法， 团队科学目标3整合：将翻译研究整合到整个研究中 连续体、学科、人群和整个生命周期;目标4方法/过程： 制定和传播创新方法和办法， 翻译科学发现的操作障碍。目标5信息学：纳入尖端技术 信息学工具和方法在翻译研究的各个方面。 我们相信，我们在与合作伙伴和社区的互动方面取得了非凡的进展， 在我们的活动，并有很好的定位，以推进我们的使命作为一个公立大学CTSA。 展望未来，我们将进一步让利益相关者参与研究过程;培训下一个 产生翻译研究人员在跨学科团队中蓬勃发展;有效地 协同临床研究与卫生保健，以确定未满足的需求和实施解决方案， 特别是对健康状况不佳的风险人群;并迅速传播我们的研究结果 我们的病人，我们的社区合作伙伴，和CTSA联盟。 项目摘要/摘要第176页 联系PD/PI：Buse，John B

项目成果

The Multiple Waves of COVID-19 in Patients With Inflammatory Bowel Disease: A Temporal Trend Analysis.

• DOI: 10.1093/ibd/izab339
• 发表时间: 2022-11-02
• 期刊: Inflammatory bowel diseases
• 影响因子: 4.9
• 作者: Kaplan GG;Underwood FE;Coward S;Agrawal M;Ungaro RC;Brenner EJ;Gearry RB;Kissous-Hunt M;Lewis JD;Ng SC;Rahier JF;Reinisch W;Steinwurz F;Zhang X;Kappelman MD;Colombel JF
• 通讯作者: Colombel JF

Relapse or reinfection: Classification of malaria infection using transition likelihoods.

• DOI: 10.1111/biom.13226
• 发表时间: 2020-12
• 期刊: Biometrics
• 影响因子: 1.9
• 作者: Lin FC;Li Q;Lin JT
• 通讯作者: Lin JT

Enriching Real-world Data with Social Determinants of Health for Health Outcomes and Health Equity: Successes, Challenges, and Opportunities.

• DOI: 10.1055/s-0043-1768732
• 发表时间: 2023-08
• 期刊: Yearbook of medical informatics
• 作者: He Z;Pfaff E;Guo SJ;Guo Y;Wu Y;Tao C;Stiglic G;Bian J
• 通讯作者: Bian J

Long-Term Outcomes After Midurethral Mesh Sling Surgery for Stress Urinary Incontinence.

• DOI: 10.1097/spv.0000000000001094
• 发表时间: 2022-04-01
• 期刊: Female pelvic medicine & reconstructive surgery
• 影响因子: 1.6

Postoperative bleeding complications in patients with hemophilia undergoing major orthopedic surgery: A prospective multicenter observational study.

• DOI: 10.1111/jth.15654
• 发表时间: 2022-04
• 期刊: Journal of thrombosis and haemostasis : JTH
• 作者: Kleiboer B;Layer MA;Cafuir LA;Cuker A;Escobar M;Eyster ME;Kraut E;Leavitt AD;Lentz SR;Quon D;Ragni MV;Thornhill D;Wang M;Key NS;Buckner TW
• 通讯作者: Buckner TW