North Carolina Translational and Clinical Science Institute (NC TraCS)

北卡罗来纳州转化与临床科学研究所 (NC TraCS)

• 批准号: 10585423
• 负责人: John Bernard Buse
• 金额: $ 21.83万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10585423
• 关键词: Address; Advocacy; Advocate; Attention; Basic Science; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Complex; Data; Discipline; Disclosure; Disease Management; Environment; Faculty; Fostering; Funding; Goals; Grant; Growth; Health; Health Personnel; Healthcare; Healthcare Systems; Informatics; Infrastructure; Institutes; Institution; Interdisciplinary Study; International; Investments; Lead; Leadership; Legal patent; Lesbian Gay Bisexual Transgender; Licensing; Longevity; Manuscripts; Mental Health; Mentors; Methodology; Methods; Mission; Modeling; National Center for Advancing Translational Sciences; North Carolina; Obesity; Outcome; Participant; Pathway interactions; Patients; Phase; Policies; Population; Populations at Risk; Positioning Attribute; Process; Provider; Public Health; Publications; Publishing; Reproducibility; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Role; Rural Population; Science; Sea; Services; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Substance abuse problem; Techniques; Testing; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Work; Workforce Development; career development; community intervention; community organizations; design; disability; ethnic minority population; evidence base; health care availability; human disease; income disparities; informatics tool; innovation; invention; literacy; low socioeconomic status; member; multi-site trial; next generation; novel; novel strategies; programs; racial minority; recruit; research study; rural counties; skills; success; tool; translational impact; translational pipeline; translational scientist

Contact PD/PI: Buse, John B Overall Abstract Since our inception in 2008, the UNC CTSA affiliate, the North Carolina Translational and Clinical Sciences Institute (TraCS) has transformed clinical and translational science at UNC through interdisciplinary research, training, collaboration with partners and stakeholders, and strong engagement across the CTSA consortium. We have built a dynamic regional network of universities, research institutes, health care providers, and >130 community organizations across our state. In the coming funding period, we propose to add NC State University in addition to RTI International and NC A&T University as full partners in our CTSA hub. Our research infrastructure has engaged 3,234 registered members, resolved 11,147 research service requests, trained 63 faculty in our KL2 program, and supported 705 pilot grants, resulting in >$170M in external research funding, and >600 published manuscripts that have been cited >21,000 times. TraCS developed Join the Conquest, an online engagement tool to increase participation in clinical trials, that includes over 6,000 registered participants and over 200 unique research studies. The TraCS 4D Strategic Initiative and KickStart Program have facilitated 141 invention disclosures, 99 patents, 40 licenses, $57M in SBIR/STTR grants, and the creation of 68 new companies. Over the next five years, we will translate the best science from UNC and across the CTSA consortium into creative, effective, and accessible clinical and community interventions, addressing the public health problems of our state and advancing national CTSA goals by completing our Overall Aims. Aim 1 Workforce Development: Develop and support a skilled and diverse clinical and translational research workforce to advance translational innovations and address healthcare priorities. Aim 2 Collaboration and Engagement: Engage diverse stakeholders as active partners in translational research, and promote innovative approaches to team science. Aim 3 Integration: Integrate translational research across the research continuum, disciplines, populations, and throughout the lifespan; Aim 4 Methods/Processes: Develop and disseminate innovative methods and approaches to address scientific and operational barriers to translating scientific findings. Aim 5 Informatics: Incorporate cutting-edge informatics tools and methodologies in every aspect of translational research. We believe that we have made exceptional strides in engaging our partners and our community in our activities and are well positioned to advance our mission as a public university CTSA. Going forward, we will further engage our stakeholders in the research process; train the next generation of translational researchers to flourish within interdisciplinary teams; effectively synergize clinical research with health care to identify unmet needs and implement solutions, particularly for populations at risk for poor health outcomes; and rapidly disseminate our findings to our patients, our community partners, and the CTSA Consortium. Project Summary/Abstract Page 176 Contact PD/PI: Buse, John B

联系PD/PI：BUSE，John B 总体摘要 自我们2008年成立以来，北卡罗来纳州州立大学CTSA附属机构、北卡罗来纳州翻译和 临床科学研究所(TraCS)改变了北卡罗来纳大学的临床和翻译科学 通过跨学科研究、培训、与合作伙伴和利益相关者协作，以及 CTSA财团的强大参与度。我们已经建立了一个充满活力的区域网络， 大学、研究机构、医疗保健提供者和130个社区组织 横跨我们的州。在接下来的资助期，我们建议将北卡罗来纳国立大学 此外，RTI国际和北卡罗来纳农工大学作为我们CTSA中心的全面合作伙伴。我们的 研究基础设施吸引了3234名注册成员，解决了11,147项研究 服务请求，在我们的KL2计划中培训了63名教职员工，并支持了705项试点拨款， 导致&gt；获得1.7亿美元的外部研究资金，以及&gt；600篇出版的手稿 被引用21,000次。TRACS开发了加入征服，这是一个在线参与工具，以 增加对临床试验的参与，包括6,000多名注册参与者和 200项独特的研究。TraCS 4D战略计划和KickStart计划 促进了141项发明披露、99项专利、40项许可证、5700万美元的SBIR/STTR拨款，以及 创建68家新公司。 在接下来的五年里，我们将把北卡罗来纳大学和整个CTSA最好的科学成果 创新、有效和可获得的临床和社区干预措施； 通过以下方式解决我们州的公共卫生问题和推进国家CTSA目标 完成我们的总体目标。目标1员工队伍发展：培养和支持熟练员工 和多样化的临床和转化型研究人员，以推进转化型创新 并解决医疗保健的优先事项。目标2协作和参与：参与多样化 将利益相关者作为翻译研究的积极合作伙伴，并推动创新方法 团队科学。目标3整合：整合整个研究中的翻译研究 连续体、学科、群体和整个生命周期；目标4个方法/过程： 开发和传播创新的方法和途径，以解决科学和 翻译科学发现的操作障碍。目标5信息学：融合尖端技术 翻译研究方方面面的信息学工具和方法。 我们相信，我们在吸引我们的合作伙伴和我们的社区方面取得了非凡的进展 在我们的活动中，并处于有利地位，推动我们作为一所公立大学CTSA的使命。 展望未来，我们将进一步让我们的利益相关者参与研究过程；培训下一位 一代翻译研究人员在跨学科团队中蓬勃发展；有效 将临床研究与卫生保健相结合，以确定未得到满足的需求并实施解决方案， 特别是针对健康状况不佳的风险人群；并迅速传播我们的研究结果 我们的患者、我们的社区合作伙伴和CTSA联盟。 项目摘要/摘要页176 联系PD/PI：BUSE，John B

项目成果

The Multiple Waves of COVID-19 in Patients With Inflammatory Bowel Disease: A Temporal Trend Analysis.

• DOI: 10.1093/ibd/izab339
• 发表时间: 2022-11-02
• 期刊: Inflammatory bowel diseases
• 影响因子: 4.9
• 作者: Kaplan GG;Underwood FE;Coward S;Agrawal M;Ungaro RC;Brenner EJ;Gearry RB;Kissous-Hunt M;Lewis JD;Ng SC;Rahier JF;Reinisch W;Steinwurz F;Zhang X;Kappelman MD;Colombel JF
• 通讯作者: Colombel JF

Relapse or reinfection: Classification of malaria infection using transition likelihoods.

• DOI: 10.1111/biom.13226
• 发表时间: 2020-12
• 期刊: Biometrics
• 影响因子: 1.9
• 作者: Lin FC;Li Q;Lin JT
• 通讯作者: Lin JT

Enriching Real-world Data with Social Determinants of Health for Health Outcomes and Health Equity: Successes, Challenges, and Opportunities.

• DOI: 10.1055/s-0043-1768732
• 发表时间: 2023-08
• 期刊: Yearbook of medical informatics
• 作者: He Z;Pfaff E;Guo SJ;Guo Y;Wu Y;Tao C;Stiglic G;Bian J
• 通讯作者: Bian J

Long-Term Outcomes After Midurethral Mesh Sling Surgery for Stress Urinary Incontinence.

• DOI: 10.1097/spv.0000000000001094
• 发表时间: 2022-04-01
• 期刊: Female pelvic medicine & reconstructive surgery
• 影响因子: 1.6

Postoperative bleeding complications in patients with hemophilia undergoing major orthopedic surgery: A prospective multicenter observational study.

• DOI: 10.1111/jth.15654
• 发表时间: 2022-04
• 期刊: Journal of thrombosis and haemostasis : JTH
• 作者: Kleiboer B;Layer MA;Cafuir LA;Cuker A;Escobar M;Eyster ME;Kraut E;Leavitt AD;Lentz SR;Quon D;Ragni MV;Thornhill D;Wang M;Key NS;Buckner TW
• 通讯作者: Buckner TW