BIOLOGICAL BASES OF ALCOHOLISM

酗酒的生物学基础

• 批准号: 10408329
• 负责人: Andrey E Ryabinin
• 金额: $ 44.94万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408329
• 关键词: Alcoholism; Biological; base

Project Summary / Abstract The overarching aim of this pre- and post-doctoral training program is to develop specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol (ethanol) use disorders. Twenty members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU—Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent areas of common interest, such as genetic bases for ethanol responses and risk, learned and unlearned determinants of ethanol reward, neurobiological bases for the rewarding, aversive and neuropathological effects of ethanol, neuroadaptive mechanisms associated with repeated and/or developmental ethanol exposure, ethanol dependence and sensitization, and effects of ethanol on memory, cognition and social behavior. In addition, comparison to the effects of other drugs of abuse is of significant interest. Technical strategies reflect three levels of analysis: I. Behavioral/cognitive/social, II. Neurophysiological/neuropharmacological/systems, III. Cellular/molecular/genomic biological. Coordinated research efforts within the Portland Alcohol Research Center (PARC), the Integrative Neuroscience Initiative on Alcoholism (INIA) and Oregon National Primate Research Center (ONPRC) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in ethanol and drug addiction, and extensive and continuous participation in research. Four predoctoral trainees per year will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year will be supported by the training grant for 2 years. We have a well-developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.

项目总结/摘要 这个博士前和博士后培训计划的总体目标是培养能够 进行从分子到认知/临床、生物学和医学等层面的基础研究。 酒精（乙醇）使用障碍的病因学、治疗和预防机制。二十 俄勒冈州健康与科学大学（OHSU）研究生教师的成员担任导师， 博士前学生和博士后研究员在两个研究生课程在OHSU行为 神经科学和神经科学研究生课程。主要研究兴趣代表了共同的领域 兴趣，如乙醇反应和风险的遗传基础，乙醇的学习和非学习决定因素 奖励，乙醇的奖励，厌恶和神经病理学影响的神经生物学基础， 与重复和/或发育性乙醇暴露相关的神经适应机制， 依赖性和敏感性，以及乙醇对记忆、认知和社会行为的影响。此外，本发明还提供了一种方法， 与其他滥用药物的影响进行比较具有重要意义。技术战略反映了三个 分析层次：I。行为/认知/社会，II。神经生理学/神经药理学/系统，III。 细胞/分子/基因组生物学。协调波特兰酒精研究所的研究工作 中心（PARC），酒精中毒综合神经科学倡议（INIA）和俄勒冈州国家灵长类动物 研究中心（ONPRC）通过统一研究人员和建立多维度的 研究项目。培训内容包括基础科学、特定药理学、 酒精和药物成瘾方面的培训，以及广泛和持续参与研究。四个博士前 每年的受训人员将得到培训补助金的支持，为期2-3年，然后由个人国家研究 服务奖或导师资源。每年将有三名博士后学员获得 两年的培训补助金。我们有一个完善的计划，以提高我们的学员和所有的多样性， 受训人员还将完成一个关于负责任的研究行为的初步强化课程， 继续教育在这方面。我们的学员有充分的机会参与公共活动， 教育和推广。