Biological Bases of Alcoholism

酗酒的生物学基础

• 批准号: 9093656
• 负责人: Andrey E Ryabinin
• 金额: $ 46.79万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9093656
• 关键词: Alcoholism; Biological; base

DESCRIPTION (provided by applicant): This program for pre- and post-doctoral training supports the training of specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol use disorders. Twenty-three members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU-Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of common interest: (1) genetic bases for alcohol and responses and risk, (2) learned and unlearned determinants of alcohol and drug reward, (3) neurobiological bases for the rewarding and aversive effects of alcohol and other drugs, (4) neuroadaptive mechanisms associated with ethanol dependence and sensitization, and (5) effects of alcohol on memory and cognition. Technical strategies reflect four levels of analysis: I. Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological, III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level. Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in alcohol and other abused drugs, and extensive and continuous participation in research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year with 0-1 years of postdoctoral experience will be supported by the training grant for 2 years. We have a well developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.

描述(由申请者提供)：这一博士后和博士后培训计划支持对能够在分子水平到认知/临床水平上进行基础研究的专家的培训，这些研究涉及酒精使用障碍的病因、治疗和预防的生物学机制。俄勒冈健康与科学大学(OHSU)的23名研究生教员在OHSU的两个研究生项目-行为神经科学和神经科学研究生项目中担任博士后研究生和博士后研究员的导师。主要研究兴趣代表了五个共同感兴趣的领域：(1)酒精与反应和风险的遗传基础，(2)酒精和药物奖励的已知和未知决定因素，(3)酒精和其他药物奖励和厌恶效应的神经生物学基础，(4)与酒精依赖和敏感化有关的神经适应机制，以及(5)酒精对记忆和认知的影响。技术战略反映了四个层面的分析：一.行为药理学/药物遗传学；二.神经化学/神经生理学/神经药理学；三.细胞/分子生物学；四.认知神经科学/社会，包括人类/临床层面。波特兰酒精研究中心(PARC)和酒精中毒综合神经科学倡议(INIA)内部的协调研究努力通过统一调查人员和创建多层面研究项目加强了培训。培训包括在基础科学方面打下坚实的课程基础，对酒精和其他滥用药物进行具体的药理学培训，以及广泛和持续地参与研究。每年6名博士前实习生，从0-2年的研究生经验开始，将得到为期2-3年的培训补助金的支持，然后由个人国家研究服务奖或其导师的资源支持。每年3名具有0-1年博士后工作经验的博士后学员，由培训助学金支持，为期2年。我们有一个完善的计划，以改善我们的学员的多样性，所有学员应完成负责任的研究行为的初步强化课程，以及这一领域的继续教育。我们的学员有很多机会参与公众教育和外展。